Berislav V Zlokovic, MD, PhD

Chair and University Professor of Physiology & Neuroscience

Mary Hayley and Selim Zilkha Chair in Alzheimer's Disease Research

Director, Zilkha Neurogenetic Institute

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Overview

Berislav Zlokovic, MD, PhD is the University Professor, Mary Hayley and Selim K. Zilkha Chair in Alzheimer’s Disease Research, director of the Zilkha Neurogenetic Institute and Professor and Chair of the Department of Physiology & Neuroscience at the Keck School of Medicine of USC. Zlokovic studies the role of brain microcirculation, particularly the blood-brain barrier (BBB) in health and disease in the adult and aging brain. He made major contributions to our understanding of the role of BBB in the pathogenesis and treatment of Alzheimer’s disease (AD) and stroke. Using animal models and studying human brain, his laboratory has shown that dysfunction in the BBB and brain microcirculation can accumulate before neuronal loss and is an early biomarker of human cognitive dysfunction. His group showed that disrupted cross-talk between BBB-associated pericytes and brain capillary endothelial cells within the neurovascular unit leads to neuronal dysfunction in both synapses and neurons. He showed that targeting the BBB cellular and molecular pathways by gene and cell therapy approaches, small molecules and/or biologics can slow down, arrest and/or prevent development of neurodegenerative changes. He has identified genes and receptors at the BBB that regulate brain levels of Alzheimer’s amyloid-beta toxin, which accumulates with aging and in AD. His team has developed new imaging techniques for studying BBB function in animal models and the living human brain. His findings contributed to development of Phase 2/3 clinical trials for AD. He co-discovered with J.H. Griffin vasculoprotective, neuroprotective, and anti-inflammatory activities of activated protein C (APC) in the CNS, including the receptor requirements and downstream signaling pathways. These findings have been translated in successfully completed Ph 1 and Ph 2 trial of 3K3A-APC, a 2nd generation cell-signaling APC analog, in ischemic stroke patients, which led to a Ph 3 efficacy pivotal trial of 3K3A-APC in patients with ischemic stroke.

Current research interests:
• We study humans at genetic risk for AD, use transgenic models, and iPSC-based human models of the BBB to understand how genes that carry risk for sporadic AD (APOE4, PICALM) affect the cerebrovascular system contributing to dementia, and AD onset and progression.
• We are developing gene and cell therapy approaches for AD using i) BBB cell-specific gene delivery; and ii) iPSC-derived human pericytes to influence and protect neuronal and synaptic functions.
• We study APC biologics and mimetic peptides in the white matter stroke, AD and ALS.
• We work on identifying small molecules that influence genes/pathways linked to AD.
• We work on CSF and imaging BBB biomarkers of human cognitive dysfunction.
• We initiated program on BBB molecular signatures (snRNAseq, proteome) in health and disease using transgenic and human models, and human brain tissue.
• Recently, we have initiated studies to understand how gut microbiome influences BBB in relation to neuronal and synaptic functions using transgenic models of AD.

Zlokovic is recognized internationally as a leader in the fields of AD and stroke research. Thomson Reuters and Clarivate Analytics listed Zlokovic as one of “The World’s Most Influential Scientific Minds” for 21 consecutive years (2002-2022) for ranking in 1 % of the most-cited authors in the field of neurosciences and behavioral sciences. He received the MetLife Award for Medical Research for “significant contributions to our understanding of Alzheimer’s disease and for bringing us closer to a cure”, the Potamkin Prize from the American Academy of Neurology in recognition of “outstanding achievements in research on Alzheimer’s and related neurodegenerative diseases”, the Javits Award from the NINDS in recognition of “distinguished record of substantial contributions in a field of neurological sciences”, the MERIT Award from the NIA in recognition of “sustained contribution to aging and leadership and commitment to the field”, and the USC Associates Award for Creativity in Research and Scholarship “the highest honor the university faculty bestows on its members for distinguished intellectual achievements”. He is the University Professor “awarded very selectively by the President based on multi-disciplinary interests and significant accomplishments in several disciplines”. He is fellow of the AAAS, The European Academy of Sciences, and The Dana Alliance for Brain Initiative. He was appointed nominator for the Nobel Prize in Physiology and Medicine for 5 consecutive years (2017-2022). He is an active entrepreneur and inventor. He co-founded ZZ Biotech, a biotechnology company that is developing treatments for stroke and neurological disorders.

Publications

  • Retraction Note: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system Nat Med. 2024 Apr 05. . View in PubMed
  • Retraction Note: Pericyte loss influences Alzheimer-like neurodegeneration in mice Nat Commun. 2024 Apr 03; 15(1):2882. . View in PubMed
  • Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-ß42 by LRP1-dependent apolipoprotein E isoform-specific mechanism Mol Neurodegener. 2024 Mar 22; 19(1):27. . View in PubMed
  • Retraction Note: Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C Nat Med. 2024 Mar 20. . View in PubMed
  • Editorial Expression of Concern: Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage Nat Med. 2024 Mar 20. . View in PubMed
  • The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity Nat Commun. 2024 Feb 03; 15(1):1037. . View in PubMed
  • Erratum: “Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model” Environ Health Perspect. 2024 Feb; 132(2):29001. . View in PubMed
  • Analysis of brain edema in RHAPSODY Int J Stroke. 2024 Jan; 19(1):68-75. . View in PubMed
  • Fluid biomarkers of the neurovascular unit in cerebrovascular disease and vascular cognitive disorders: A systematic review and meta-analysis Cereb Circ Cogn Behav. 2024; 6:100216. . View in PubMed
  • Author Correction: Central role for PICALM in amyloid-ß blood-brain barrier transcytosis and clearance Nat Neurosci. 2024 Jan; 27(1):208. . View in PubMed
  • Activated Protein C Prevents Neuronal Apoptosis via Protease Activated Receptors 1 and 3 Neuron. 2023 Dec 20; 111(24):4116. . View in PubMed
  • Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging Neuron. 2023 Oct 04; 111(19):3131-3132. . View in PubMed
  • Author Correction: Pericyte loss influences Alzheimer-like neurodegeneration in mice Nat Commun. 2023 Oct 03; 14(1):6151. . View in PubMed
  • TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice Cell Rep. 2023 Aug 29; 42(8):113050. . View in PubMed
  • Magnetic resonance imaging of white matter response to diesel exhaust particles Res Sq. 2023 Jul 18. . View in PubMed
  • Author Correction: Apolipoprotein E controls cerebrovascular integrity via cyclophilin A Nature. 2023 May; 617(7961):E12. . View in PubMed
  • Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRß, a marker of blood brain barrier breakdown, in older adults Res Sq. 2023 Mar 07. . View in PubMed
  • Correction: Anti-malaria drug artesunate prevents development of amyloid-ß pathology in mice by upregulating PICALM at the blood-brain barrier Mol Neurodegener. 2023 Feb 24; 18(1):14. . View in PubMed
  • Molecular biomarkers for vascular cognitive impairment and dementia Nat Rev Neurol. 2023 12; 19(12):737-753. . View in PubMed
  • The small HDL particle hypothesis of Alzheimer’s disease Alzheimers Dement. 2023 02; 19(2):391-404. . View in PubMed
  • PIKFYVE inhibition mitigates disease in models of diverse forms of ALSCell. 2023 02 16; 186(4):786-802. e28. . View in PubMed
  • Characterization of spastic paraplegia in a family with a novel PSEN1 mutation Brain Commun. 2023; 5(2):fcad030. . View in PubMed
  • Anti-malaria drug artesunate prevents development of amyloid-ß pathology in mice by upregulating PICALM at the blood-brain barrier Mol Neurodegener. 2023 01 27; 18(1):7. . View in PubMed
  • Nutritional metabolism and cerebral bioenergetics in Alzheimer’s disease and related dementias Alzheimers Dement. 2022 Dec 08. . View in PubMed
  • Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-ß42 by LRP1-dependent apolipoprotein E isoform-specific mechanism Mol Neurodegener. 2022 Nov 03; 17(1):71. . View in PubMed
  • Blood-brain barrier link to human cognitive impairment and Alzheimer’s Disease Nat Cardiovasc Res. 2022 Feb; 1(2):108-115. . View in PubMed
  • Brain barriers and their potential role in migraine pathophysiology J Headache Pain. 2022 Jan 26; 23(1):16. . View in PubMed
  • Characterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imaging J Cereb Blood Flow Metab. 2022 10; 42(10):1813-1826. . View in PubMed
  • Imaging subtle leaks in the blood-brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions Geroscience. 2022 06; 44(3):1339-1351. . View in PubMed
  • How the brain regulates its own immune system Nat Neurosci. 2022 05; 25(5):532-534. . View in PubMed
  • Prenatal disruption of blood-brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2113310119. . View in PubMed
  • Corrigendum: Acute ablation of cortical pericytes leads to rapid neurovascular uncoupling Front Cell Neurosci. 2022; 16:1078919. . View in PubMed
  • Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C J Exp Med. 2022 01 03; 219(1). . View in PubMed
  • A “multi-omics” analysis of blood-brain barrier and synaptic dysfunction in APOE4 mice J Exp Med. 2022 11 07; 219(11). . View in PubMed
  • 3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice Front Neurosci. 2022; 16:841916. . View in PubMed
  • A single-cell atlas of the normal and malformed human brain vasculature Science. 2022 03 04; 375(6584):eabi7377. . View in PubMed
  • Author Correction: APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer’s mice via cyclophilin A independently of amyloid-ß Nat Aging. 2021 Jul; 1(7):624. . View in PubMed
  • Investigating the blood-spinal cord barrier in preclinical models: a systematic review of in vivo imaging techniques Spinal Cord. 2021 Jun; 59(6):596-612. . View in PubMed
  • Evidence that blood-CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen Headache. 2021 Mar; 61(3):536-545. . View in PubMed
  • Editorial for “MRI-Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure” J Magn Reson Imaging. 2021 11; 54(5):1527-1528. . View in PubMed
  • Reply to: Rethink the classical view of cerebrospinal fluid production Nat Rev Neurol. 2021 09; 17(9):590-591. . View in PubMed
  • Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model Environ Health Perspect. 2021 08; 129(8):87006. . View in PubMed
  • APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer’s mice via cyclophilin A independently of amyloid-ß Nat Aging. 2021 06; 1(6):506-520. . View in PubMed
  • Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults Brain Behav Immun. 2021 05; 94:299-307. . View in PubMed
  • A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease Transl Stroke Res. 2021 02; 12(1):15-30. . View in PubMed
  • Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A J Exp Med. 2021 04 05; 218(4). . View in PubMed
  • On the intersection between systemic infection, brain vascular dysfunction and dementia Brain. 2021 07 28; 144(6):1629-1631. . View in PubMed
  • Microglia have a grip on brain microvasculature Nat Commun. 2021 09 06; 12(1):5290. . View in PubMed
  • Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion Front Immunol. 2021; 12:785519. . View in PubMed
  • Can prehospital “plasma supplement” neutralize the systemic storm in severe trauma? Cell Rep Med. 2021 12 21; 2(12):100481.. View in PubMed
  • Stroke Treatment With PAR-1 Agents to Decrease Hemorrhagic Transformation Front Neurol. 2021; 12:593582. . View in PubMed
  • Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in CraniosynostosisCell. 2021 01 07; 184(1):243-256. e18. . View in PubMed
  • Acetylated tau: A missing link between head injury and dementia Med (N Y). 2021 06 11; 2(6):637-639. . View in PubMed
  • Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial EBioMedicine. 2020 Sep; 59:102883. . View in PubMed
  • Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop Alzheimers Dement. 2020 12; 16(12):1714-1733. . View in PubMed
  • 3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase Stroke. 2020 07; 51(7):2236-2239. . View in PubMed
  • Building vascular roadmaps: A novel toolset for visualizing and annotating whole mouse brain vasculature Lab Anim (NY). 2020 06; 49(6):175-176. . View in PubMed
  • A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid Alzheimers Dement. 2020 06; 16(6):821-830. . View in PubMed
  • APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline Nature. 2020 05; 581(7806):71-76. . View in PubMed
  • Perivascular spaces in the brain: anatomy, physiology and pathology Nat Rev Neurol. 2020 03; 16(3):137-153. . View in PubMed
  • APOE4 Accelerates Development of Dementia After Stroke: Is There a Role for Cerebrovascular Dysfunction? Stroke. 2020 03; 51(3):699-700.. View in PubMed
  • Every-other-day feeding exacerbates inflammation and neuronal deficits in 5XFAD mouse model of Alzheimer’s disease Neurobiol Dis. 2020 03; 136:104745. . View in PubMed
  • Functional connectivity among brain regions affected in Alzheimer’s disease is associated with CSF TNF-a in APOE4 carriers Neurobiol Aging. 2020 02; 86:112-122. . View in PubMed
  • Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo Front Aging Neurosci. 2020; 12:108. . View in PubMed
  • Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline PLoS One. 2020; 15(5):e0232785. . View in PubMed
  • Endothelial Tip Cell Finds Its Way with Piezo1 Neuron. 2020 10 14; 108(1):5-7. . View in PubMed
  • Comparison Between Blood-Brain Barrier Water Exchange Rate and Permeability to Gadolinium-Based Contrast Agent in an Elderly Cohort Front Neurosci. 2020; 14:571480. . View in PubMed
  • Therapeutic TVs for Crossing Barriers in the Brain Cell. 2020 07 23; 182(2):267-269. . View in PubMed
  • Associations between Vascular Function and Tau PET Are Associated with Global Cognition and Amyloid J Neurosci. 2020 10 28; 40(44):8573-8586. . View in PubMed
  • Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling Front Cell Neurosci. 2020; 14:27. . View in PubMed
  • Correction: Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline PLoS One. 2020; 15(7):e0236379. . View in PubMed
  • Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-ß from the brain and retina with age and Alzheimer’s disease-Opportunities for Therapy Alzheimers Dement (Amst). 2020; 12(1):e12053. . View in PubMed
  • Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto Int J Stroke. 2019 Sep 22; 1747493019871915. . View in PubMed
  • Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment Alzheimers Dement. 2019 12; 15(12):1568-1575. . View in PubMed
  • Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss Nat Neurosci. 2019 07; 22(7):1089-1098. . View in PubMed
  • Preventing dementia by preventing stroke: The Berlin Manifesto Alzheimers Dement. 2019 07; 15(7):961-984. . View in PubMed
  • Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood-brain barrier permeability in the corpus callosum J Cereb Blood Flow Metab. 2019 02; 39(2):240-250. . View in PubMed
  • Prion Protein Antagonists Rescue Alzheimer’s Amyloid-ß-Related Cognitive Deficits Trends Mol Med. 2019 02; 25(2):74-76. . View in PubMed
  • Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction Nat Med. 2019 02; 25(2):270-276. . View in PubMed
  • Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke Ann Neurol. 2019 01; 85(1):125-136. . View in PubMed
  • Vascular dysfunction-The disregarded partner of Alzheimer’s disease Alzheimers Dement. 2019 01; 15(1):158-167. . View in PubMed
  • Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular ReprogrammingCell Stem Cell. 2019 10 03; 25(4):486-500. e9. . View in PubMed
  • Blood-Brain Barrier: From Physiology to Disease and Back Physiol Rev. 2019 01 01; 99(1):21-78. . View in PubMed
  • 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice J Exp Med. 2019 02 04; 216(2):279-293. . View in PubMed
  • Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis Am J Physiol Heart Circ Physiol. 2019 08 01; 317(2):H255-H263. . View in PubMed
  • Short-term fish oil supplementation applied in presymptomatic stage of Alzheimer’s disease enhances microglial/macrophage barrier and prevents neuritic dystrophy in parietal cortex of 5xFAD mouse model PLoS One. 2019; 14(5):e0216726. . View in PubMed
  • TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in MiceCell Rep. 2019 04 09; 27(2):549-560. e6. . View in PubMed
  • Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons JCI Insight. 2019 07 16; 5. . View in PubMed
  • The role of brain vasculature in neurodegenerative disorders Nat Neurosci. 2018 10; 21(10):1318-1331. . View in PubMed
  • A lymphatic waste-disposal system implicated in Alzheimer’s disease Nature. 2018 08; 560(7717):172-174. . View in PubMed
  • In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain Nat Protoc. 2018 06; 13(6):1377-1402. . View in PubMed
  • Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage J Cereb Blood Flow Metab. 2018 06; 38(6):973-979. . View in PubMed
  • Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders Nat Rev Neurol. 2018 03; 14(3):133-150. . View in PubMed
  • Pericyte degeneration causes white matter dysfunction in the mouse central nervous system Nat Med. 2018 03; 24(3):326-337. . View in PubMed
  • Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons Nat Med. 2018 03; 24(3):313-325. . View in PubMed
  • PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke Blood. 2018 03 15; 131(11):1163-1171. . View in PubMed
  • Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol Neurosurgery. 2018 06 01; 82(6):770-780. . View in PubMed
  • Activated protein C, protease activated receptor 1, and neuroprotection Blood. 2018 07 12; 132(2):159-169. . View in PubMed
  • Understanding the role of the perivascular space in cerebral small vessel disease Cardiovasc Res. 2018 09 01; 114(11):1462-1473. . View in PubMed
  • Neuropharmacology. 2018 05 15; 134(Pt B):293-301. . View in PubMed
  • Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-ß42 by LRP1-dependent apolipoprotein E isoform-specific mechanism Mol Neurodegener. 2018 10 19; 13(1):57. . View in PubMed
  • Alzheimer’s disease: A matter of blood-brain barrier dysfunction? J Exp Med. 2017 Nov 06; 214(11):3151-3169.. View in PubMed
  • NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface Fluids Barriers CNS. 2017 May 01; 14(1):12. . View in PubMed
  • Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain Nat Neurosci. 2017 Mar; 20(3):406-416. . View in PubMed
  • Remote control of BBB: A tale of exosomes and microRNA Cell Res. 2017 07; 27(7):849-850. . View in PubMed
  • Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease Nat Rev Neurosci. 2017 07; 18(7):419-434. . View in PubMed
  • Role of clusterin in the brain vascular clearance of amyloid-ß Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8681-8682. . View in PubMed
  • Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-ß signaling PLoS One. 2017; 12(4):e0176225. . View in PubMed
  • Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI Magn Reson Med. 2016 May; 75(5):1967-77. . View in PubMed
  • Brain imaging of neurovascular dysfunction in Alzheimer’s disease Acta Neuropathol. 2016 May; 131(5):687-707. . View in PubMed
  • Activated protein C promotes neuroprotection: mechanisms and translation to the clinic Thromb Res. 2016 May; 141 Suppl 2:S62-4. . View in PubMed
  • Clearance systems in the brain–implications for Alzheimer diseaser Nat Rev Neurol. 2016 Apr; 12(4):248. . View in PubMed
  • 2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C Arterioscler Thromb Vasc Biol. 2016 11; 36(11):2143-2151. . View in PubMed
  • 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice Nat Med. 2016 09; 22(9):1050-5. . View in PubMed
  • Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer’s disease Biochim Biophys Acta. 2016 05; 1862(5):887-900. . View in PubMed
  • Neurovascular and Immuno-Imaging: From Mechanisms to TherapiesProceedings of the Inaugural Symposium. Front Neurosci. 2016; 10:46. . View in PubMed
  • Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy Cell Stem Cell. 2016 11 03; 19(5):663-671. . View in PubMed
  • Consensus statement for diagnosis of subcortical small vessel disease J Cereb Blood Flow Metab. 2016 Jan; 36(1):6-25. . View in PubMed
  • Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease J Cereb Blood Flow Metab. 2016 Jan; 36(1):216-27. . View in PubMed
  • Pericytes of the neurovascular unit: key functions and signaling pathways Nat Neurosci. 2016 05 26; 19(6):771-83. . View in PubMed
  • Blood-Brain Barrier Permeability and Gadolinium: Benefits and Potential Pitfalls in Research JAMA Neurol. 2016 Jan; 73(1):13-4. . View in PubMed
  • Establishment and Dysfunction of the Blood-Brain Barrier Cell. 2015 Nov 19; 163(5):1064-1078. . View in PubMed
  • Shedding of soluble platelet-derived growth factor receptor-ß from human brain pericytes Neurosci Lett. 2015 Oct 21; 607:97-101. . View in PubMed
  • Clearance systems in the brain-implications for Alzheimer disease Nat Rev Neurol. 2015 Aug; 11(8):457-70. . View in PubMed
  • Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer’s disease J Cereb Blood Flow Metab. 2015 Jul; 35(7):1055-68. . View in PubMed
  • Central role for PICALM in amyloid-ß blood-brain barrier transcytosis and clearance Nat Neurosci. 2015 Jul; 18(7):978-87. . View in PubMed
  • ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies BMC Med Imaging. 2015 Jun 16; 15:19. . View in PubMed
  • Vascular contributions to cognitive impairment and dementia including Alzheimer’s disease Alzheimers Dement. 2015 Jun; 11(6):710-7. . View in PubMed
  • Activated protein C: biased for translation Blood. 2015 May 07; 125(19):2898-907. . View in PubMed
  • Vascular plasticity and cognition during normal aging and dementia JAMA Neurol. 2015 May; 72(5):495-6. . View in PubMed
  • GLUT1 reductions exacerbate Alzheimer’s disease vasculo-neuronal dysfunction and degeneration Nat Neurosci. 2015 Apr; 18(4):521-530. . View in PubMed
  • 7T Multi-shell Hybrid Diffusion Imaging (HYDI) for Mapping Brain Connectivity in Mice Proc SPIE Int Soc Opt Eng. 2015 Mar 20; 9413. . View in PubMed
  • Blood-brain barrier breakdown in the aging human hippocampus Neuron. 2015 Jan 21; 85(2):296-302. . View in PubMed
  • Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1 Front Aging Neurosci. 2015; 7:136. . View in PubMed
  • Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke Front Cell Neurosci. 2015; 9:344. . View in PubMed
  • Cytoprotective-selective activated protein C therapy for ischaemic stroke Thromb Haemost. 2014 Nov; 112(5):883-92. . View in PubMed
  • Nat Commun. 2014 Sep 05; 5:4820. . View in PubMed
  • Recommendations of the Alzheimer’s disease-related dementias conference Neurology. 2014 Aug 26; 83(9):851-60. . View in PubMed
  • The pericyte: a forgotten cell type with important implications for Alzheimer’s disease? Brain Pathol. 2014 Jul; 24(4):371-86.. View in PubMed
  • Blood-brain barrier: a dual life of MFSD2A? Neuron. 2014 May 21; 82(4):728-30.. View in PubMed
  • Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):E1035-42. . View in PubMed
  • Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats Stroke. 2013 Dec; 44(12):3529-36. . View in PubMed
  • Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant’s anticoagulant activity J Thromb Haemost. 2013 Nov; 11(11):2059-62. . View in PubMed
  • Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown JAMA Neurol. 2013 Sep 01; 70(9):1198-200. . View in PubMed
  • Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice Blood Cells Mol Dis. 2013 Aug; 51(2):104-8. . View in PubMed
  • A lipoprotein receptor cluster IV mutant preferentially binds amyloid-ß and regulates its clearance from the mouse brain J Biol Chem. 2013 May 24; 288(21):15154-66. . View in PubMed
  • Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer’s disease Brain Pathol. 2013 May; 23(3):303-10. . View in PubMed
  • Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1 Brain Res. 2013 Apr 24; 1507:97-104. . View in PubMed
  • An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway J Neurosci. 2013 Apr 03; 33(14):6181-90. . View in PubMed
  • Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease JAMA Neurol. 2013 Apr; 70(4):440-4. . View in PubMed
  • A gliovascular idea for the white matter repair? J Neurochem. 2013 Apr; 125(2):172-4.. View in PubMed
  • Neurovascular defects and faulty amyloid-ß vascular clearance in Alzheimer’s disease J Alzheimers Dis. 2013; 33 Suppl 1:S87-100. . View in PubMed
  • Pericyte loss influences Alzheimer-like neurodegeneration in mice Nat Commun. 2013; 4:2932. . View in PubMed
  • Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis Acta Neuropathol. 2013 Jan; 125(1):111-20. . View in PubMed
  • Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers Curr Pharm Des. 2013; 19(42):7479-85. . View in PubMed
  • Neurovascular dysfunction and faulty amyloid ß-peptide clearance in Alzheimer disease Cold Spring Harb Perspect Med. 2012 Oct 01; 2(10). . View in PubMed
  • Low-density lipoprotein receptor-related protein 1: a physiological Aß homeostatic mechanism with multiple therapeutic opportunities Pharmacol Ther. 2012 Oct; 136(1):94-105. . View in PubMed
  • Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability J Cereb Blood Flow Metab. 2012 Oct; 32(10):1841-52. . View in PubMed
  • Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aß clearance in a mouse model of ß-amyloidosis Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15502-7. . View in PubMed
  • An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents Stroke. 2012 Sep; 43(9):2444-9. . View in PubMed
  • Hypertension induces brain ß-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature Hypertension. 2012 Jul; 60(1):188-97. . View in PubMed
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