Keck School Faculty

Aaron Nagiel, MD, PhD
Aaron Nagiel, MD, PhD
Assistant Professor of Ophthalmology
Pediatrics
4640 West Sunset Boulevard Off Campus Los Angeles
The development and maintenance of specific synaptic connections between retinal neurons is critical to its function. However, our understanding of neural circuit formation in the human retina remains limited. Within the last 10 years it has become possible to grow 3-dimensional, multi-layered retinal organoids derived from human stem cells. This advance permits the study of human retinal development and the establishment of synaptic connectivity. Our goal is to elucidate mechanisms underlying synapse formation and specificity in the first synapse of the human visual system. Access to patient-derived organoids allows us to understand this process in the disease state and following novel treatment paradigms such as gene therapy and cell-based therapy. We utilize a variety of techniques including live fluorescent imaging, electrophysiology, and gene editing in stem cell-derived human retinal organoids. The long-term goal of this work is to understand how synaptic connections are established and maintained in the human nervous system.

https://www.chla.org/research/nagiel-laboratory

: Allergan FIRST (Fostering Innovative Retina Stars of Tomorrow) Fellowship, 2016-2019

: Ronald G. Michels Fellowship Foundation Award, 2016-2017

Jules Stein Eye Institute: Excellence in Research Award, 2016

: Heed Ophthalmic Foundation Fellowship, 2015-2016

Jules Stein Eye Institute: Pepose-Saltzman Young Investigator ARVO Award, 2014-2015

: ARVO National Eye Institute Travel Grant, 2014

: Heed Foundation Residents Retreat Participant, 2014

Jules Stein Eye Institute: Excellence in Research Award, 2014

Jules Stein Eye Institute: Robert E. Christensen Research Award, 2013

The Rockefeller University: Sumi Koide Travel Fellowship, 2010

: Finalist, Paul and Daisy Soros Fellowship for New Americans, 2006

: John Harvard Scholarship, 2001-2003

Harvard University: Detur Prize, 2001

Ocular Trauma From Toy Guns With Foam Projectiles in 4 Children Clin Pediatr (Phila). 2019 Oct 28; 9922819884573. . View in PubMed

Utility of In Vitro Mutagenesis of RPE65 Protein for Verification of Mutational Pathogenicity Before Gene Therapy JAMA Ophthalmol. 2019 Oct 03; 1-9. . View in PubMed

Retinal stem cell transplantation: Balancing safety and potential Prog Retin Eye Res. 2019 Sep 05; 100779. . View in PubMed

Diagnostic and Therapeutic Challenges Retina. 2019 Jul 30. . View in PubMed

Correspondence Retina. 2019 01; 39(1):e4. . View in PubMed

Gene therapy for RPE65-mediated retinal dystrophies Surv Ophthalmol. 2018 May - Jun; 63(3):445-446. . View in PubMed

Endoscopy for Pediatric Retinal Disease Asia Pac J Ophthalmol (Phila). 2018 May-Jun; 7(3):200-207. . View in PubMed

EARLY DETECTION OF RETINAL HEMANGIOBLASTOMAS IN VON HIPPEL-LINDAU DISEASE USING ULTRA-WIDEFIELD FLUORESCEIN ANGIOGRAPHY Retina. 2018 Apr; 38(4):748-754. . View in PubMed

PERIPAPILLARY PACHYCHOROID SYNDROME Retina. 2018 09; 38(9):1652-1667. . View in PubMed

Practice Patterns of Endophthalmitis Treatment: An International Survey of Retina Specialists Ophthalmol Retina. 2018 09; 2(9):979-980. . View in PubMed

SUPERFICIAL AND DEEP CAPILLARY ISCHEMIA AS A PRESENTING SIGN OF RETINAL VASCULOPATHY WITH CEREBRAL LEUKOENCEPHALOPATHY AND SYSTEMIC MANIFESTATIONS Retin Cases Brief Rep. 2018 Fall; 12 Suppl 1:S87-S91. . View in PubMed

VITRECTOMY-ASSISTED BIOPSY FOR MOLECULAR PROGNOSTICATION OF CHOROIDAL MELANOMA 2 MM OR LESS IN THICKNESS WITH A 27-GAUGE CUTTER Retina. 2017 Jul; 37(7):1377-1382. . View in PubMed

Deformation of Optic Nerve Head and Peripapillary Tissues by Horizontal Duction Am J Ophthalmol. 2017 Feb; 174:85-94. . View in PubMed

PARANEOPLASTIC VITELLIFORM MACULOPATHY IN THE SETTING OF CHOROIDAL MELANOMA: EVOLUTION OVER ONE YEAR Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S7-S10. . View in PubMed

THE SPECTRUM OF AMALRIC TRIANGULAR CHOROIDAL INFARCTION Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S113-S120. . View in PubMed

ULTRA-WIDEFIELD FUNDUS IMAGING: A Review of Clinical Applications and Future Trends Retina. 2016 Apr; 36(4):660-78. . View in PubMed

Subretinal Transplantation of Embryonic Stem Cell-Derived Retinal Pigment Epithelium for the Treatment of Macular Degeneration: An Assessment at 4 Years Invest Ophthalmol Vis Sci. 2016 Apr 01; 57(5):ORSFc1-9. . View in PubMed

Isolated Zygomycetes Endophthalmitis: A Case Report Ophthalmic Plast Reconstr Surg. 2015 Nov-Dec; 31(6):e145-7. . View in PubMed

A Promising Future for Optical Coherence Tomography Angiography JAMA Ophthalmol. 2015 Jun; 133(6):629-30. . View in PubMed

Type 3 neovascularization: evolution, association with pigment epithelial detachment, and treatment response as revealed by spectral domain optical coherence tomography Retina. 2015 Apr; 35(4):638-47. . View in PubMed

RESOLUTION OF A GIANT PIGMENT EPITHELIAL DETACHMENT WITH HALF-DOSE AFLIBERCEPT Retin Cases Brief Rep. 2015; 9(4):269-72. . View in PubMed

Mechanism of retinal pigment epithelium tear formation following intravitreal anti-vascular endothelial growth factor therapy revealed by spectral-domain optical coherence tomographyAm J Ophthalmol. 2013 Nov; 156(5):981-988. e2. . View in PubMed

Thrombophilia in patients with retinoblastoma receiving ophthalmic artery chemosurgery Arch Ophthalmol. 2012 Dec; 130(12):1605-8. . View in PubMed

Retinopathy of prematurity residency trainingOphthalmology. 2012 Dec; 119(12):2644-5. e1-2. . View in PubMed

Activity-independent specification of synaptic targets in the posterior lateral line of the larval zebrafish Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21948-53. . View in PubMed

The transmembrane inner ear (Tmie) protein is essential for normal hearing and balance in the zebrafish Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50):21347-52. . View in PubMed

Specificity of afferent synapses onto plane-polarized hair cells in the posterior lateral line of the zebrafish J Neurosci. 2008 Aug 20; 28(34):8442-53. . View in PubMed

Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells J Biol Chem. 2004 Sep 24; 279(39):40659-69. . View in PubMed

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