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Brian Applegate, PhD

Professor of Otolaryngology - Head & Neck Surgery, Ophthalmology, Biomedical Engineering and Electrical and Computer Engineering

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Overview

Our research interests are broadly to develop novel biophotonic technologies for point-of-care diagnosis and monitoring of human disease as well as the basic scientific understanding of human disease.

Education and Training

  • The Ohio State University, Columbus, OH — PhD — 12/2000 — Chemistry

Research Funding

  • New technologies for imaging of the human cochlea
    NIH · R01DC023511 · Jul 1, 2026 – Apr 30, 2031 · Role: Principal Investigator
  • New low cost technology for early detection of ear disorders
    NIH · R21DC023404 · Sep 17, 2025 – Aug 31, 2027 · Role: Principal Investigator
  • Ultra-stable, phase sensitive, snapshot OCT system enabled by 2-Photon additive manufacturing
    NIH · R21GM149078 · Sep 15, 2023 – Aug 31, 2025 · Role: Principal Investigator
  • High-Speed, Low-Cost, Image Remapping Spectral Domain Full-Field Optical Coherence Tomography for Retinal Imaging
    NIH · R21EY035108 · Jul 1, 2023 – Jun 30, 2025 · Role: Principal Investigator
  • Comb Light Source/Imaging spectrometer for advanced Spectral Domain Optical Coherence Tomography
    NIH · R21GM135530 · Sep 1, 2020 – Aug 31, 2022 · Role: Principal Investigator
  • Optical imaging technologies to identify residual cholesteatoma and improve ossiculoplasty outcomes
    NIH · R01EB027113 · Apr 1, 2019 – Dec 31, 2023 · Role: Principal Investigator
  • Morphological and Molecular Imaging System for in vivo Atherosclerosis Research
    NIH · R01HL111361 · Apr 1, 2012 – Mar 31, 2019 · Role: Principal Investigator
  • Development of high-resolution molecular imaging of endogenous chromophores with
    NIH · R21RR025799 · May 15, 2009 – Apr 30, 2013 · Role: Principal Investigator
  • New Technologies for high resolution optical molecular imaging
    NIH · R21EB007729 · Jun 1, 2008 – May 31, 2011 · Role: Principal Investigator
  • Bringing Molecular Contrast to OCT
    NIH · F32EB004237 · Sep 1, 2004 – Aug 31, 2006 · Role: Principal Investigator

Publications

  • Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography. Opt Express. 2011 Aug 01; 19(16):15415-28.. View in PubMed
  • Cornea microstructure and mechanical responses measured with nonlinear optical and optical coherence microscopy using sub-10-fs pulses. Biomed Opt Express. 2011 Apr 11; 2(5):1135-46.. View in PubMed
  • Ultrahigh resolution photoacoustic microscopy via transient absorption. Biomed Opt Express. 2010 Aug 23; 1(2):676-686.. View in PubMed
  • High-speed multispectral fluorescence lifetime imaging implementation for in vivo applications. Opt Lett. 2010 Aug 01; 35(15):2558-60.. View in PubMed
  • In vivo simultaneous morphological and biochemical optical imaging of oral epithelial cancer. IEEE Trans Biomed Eng. 2010 Oct; 57(10):2596-9.. View in PubMed
  • A dual-modality optical coherence tomography and fluorescence lifetime imaging microscopy system for simultaneous morphological and biochemical tissue characterization. Biomed Opt Express. 2010 Jul 16; 1(1):186-200.. View in PubMed
  • Fourier domain Pump-Probe Optical Coherence Tomography imaging of melanin. Opt Express. 2010 Jun 07; 18(12):12399-410.. View in PubMed
  • Off-axis photoacoustic microscopy. IEEE Trans Biomed Eng. 2010 Aug; 57(8):1835-8.. View in PubMed
  • Multiphoton coherence domain molecular imaging with pump-probe optical coherence microscopy. Opt Lett. 2010 Feb 15; 35(4):532-4.. View in PubMed
  • Multimodal optical imaging for simultaneous in-vivo morphological and biochemical characterization of oral epithelial cancer. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:1970-3.. View in PubMed

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