Brian P. Lee, MD

Associate Professor of Clinical Medicine

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Overview

Dr. Lee is a transplant hepatologist who cares for patients with advanced liver disease and those undergoing liver transplantation. He leads ACCELERATE, an NIH-funded national research consortium, and his research program focuses on improving health for patients with alcohol use, metabolic dysfunction, and liver disease through: 1) early transplant with alcohol; 2) the overlap of alcohol and metabolic liver disease; 3) public policy and advocacy; and 4) novel therapies and translational science. He is lead author of studies in The Lancet, JAMA Internal Medicine, Annals of Internal Medicine, Gastroenterology, Journal of Hepatology, and his work has featured in New York Times, Wall Street Journal, NPR, CNN, the New Yorker, and NBC Nightly News. He has led advocacy initiatives that changed national and statewide transplant and insurance policies to improve healthcare access, and his research has been incorporated into practice guidelines across North America, Europe, Latin America, and Asia. He is first author of international expert task force consensus guidelines for clinical trial design in alcohol use and liver disease. He serves currently as Associate Editor for Hepatology, and has served as an Associate Editor for Journal of Hepatology Reports. He serves as a standing Voting Member of the FDA Gastrointestinal Drugs Advisory Committee and as a Voting Member of the FDA Pharmacy Compounding Advisory Committee.

Awards

  • European Association for the Study of the Liver: Young Investigator Bursary Award, 2019
  • American Association for the Study of Liver Diseases: Clinical/Translational Early Career Investigator Award, 2018
  • American Society of Transplantation: Young Investigator Award, 2018
  • International Liver Transplantation Society: Young Investigator Award, 2017
  • Johns Hopkins Hospital: Resident Teaching Award, 2016
  • Summa Cum Laude, 2013
  • Alpha Omega Alpha (AOA), 2013
  • Phi Beta Kappa, 2010

Education and Training

  • Johns Hopkins Osler Program — 2016 — Internal Medicine
  • UCSF — 2019 — Gastroenterology
  • UCSF — 2020 — Transplant Hepatology

Research Funding

  • American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)
    NIH · R01AA030960 · Aug 1, 2023 – Jul 31, 2030
  • Estimating the Contribution of Alcohol and Metabolic Risk to Liver Disease Progression to Inform Personalized Interventions
    NIH · K23AA029752 · Jul 15, 2022 – Jun 30, 2026 · Role: Principal Investigator
  • Estimating the Contribution of Alcohol and Metabolic Risk to Liver Disease Progression to Inform Personalized Interventions
    NIH · K23AA029752 · Jul 1, 2022 – Jun 30, 2026

Media

Publications

  • Teenager With Acute Flaccid Paralysis. Pediatr Infect Dis J. 2019 03; 38(3):329.. View in PubMed
  • Return to Alcohol Use After Liver Transplant: Patterns and Surveillance. Clin Liver Dis (Hoboken). 2018 Dec; 12(6):160-164.. View in PubMed
  • Reply. Gastroenterology. 2019 01; 156(1):286-287.. View in PubMed
  • Outcomes of Early Liver Transplantation for Patients With Severe Alcoholic Hepatitis. Gastroenterology. 2018 08; 155(2):422-430.e1.. View in PubMed
  • Early liver transplantation for severe alcoholic hepatitis: moving from controversy to consensus. Curr Opin Organ Transplant. 2018 04; 23(2):229-236.. View in PubMed
  • Three-year Results of a Pilot Program in Early Liver Transplantation for Severe Alcoholic Hepatitis. Ann Surg. 2017 01; 265(1):20-29.. View in PubMed
  • Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B. J Hepatol. 2017 02; 66(2):275-281.. View in PubMed
  • Ultrasonic Percutaneous Tenotomy for Recalcitrant Lateral Elbow Tendinopathy: Sustainability and Sonographic Progression at 3 Years. Am J Sports Med. 2016 Feb; 44(2):504-10.. View in PubMed
  • Fever, emesis, abdominal pain, and pancytopenia in a 16-year-old girl. Pediatr Infect Dis J. 2009 Oct; 28(10):931.. View in PubMed
  • Recessive NPHS2 (Podocin) mutations are rare in adult-onset idiopathic focal segmental glomerulosclerosis. Clin J Am Soc Nephrol. 2007 Jan; 2(1):31-7.. View in PubMed