Brian P. Lee, MD

Associate Professor of Clinical Medicine

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Overview

Dr. Lee is a transplant hepatologist who cares for patients with advanced liver disease and those undergoing liver transplantation. He leads ACCELERATE, an NIH-funded national research consortium, and his research program focuses on improving health for patients with alcohol use, metabolic dysfunction, and liver disease through: 1) early transplant with alcohol; 2) the overlap of alcohol and metabolic liver disease; 3) public policy and advocacy; and 4) novel therapies and translational science. He is lead author of studies in The Lancet, JAMA Internal Medicine, Annals of Internal Medicine, Gastroenterology, Journal of Hepatology, and his work has featured in New York Times, Wall Street Journal, NPR, CNN, the New Yorker, and NBC Nightly News. He has led advocacy initiatives that changed national and statewide transplant and insurance policies to improve healthcare access, and his research has been incorporated into practice guidelines across North America, Europe, Latin America, and Asia. He is first author of international expert task force consensus guidelines for clinical trial design in alcohol use and liver disease. He serves currently as Associate Editor for Hepatology, and has served as an Associate Editor for Journal of Hepatology Reports. He serves as a standing Voting Member of the FDA Gastrointestinal Drugs Advisory Committee and as a Voting Member of the FDA Pharmacy Compounding Advisory Committee.

Awards

  • European Association for the Study of the Liver: Young Investigator Bursary Award, 2019
  • American Association for the Study of Liver Diseases: Clinical/Translational Early Career Investigator Award, 2018
  • American Society of Transplantation: Young Investigator Award, 2018
  • International Liver Transplantation Society: Young Investigator Award, 2017
  • Johns Hopkins Hospital: Resident Teaching Award, 2016
  • Summa Cum Laude, 2013
  • Alpha Omega Alpha (AOA), 2013
  • Phi Beta Kappa, 2010

Education and Training

  • Johns Hopkins Osler Program — 2016 — Internal Medicine
  • UCSF — 2019 — Gastroenterology
  • UCSF — 2020 — Transplant Hepatology

Research Funding

  • American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)
    NIH · R01AA030960 · Aug 1, 2023 – Jul 31, 2030
  • Estimating the Contribution of Alcohol and Metabolic Risk to Liver Disease Progression to Inform Personalized Interventions
    NIH · K23AA029752 · Jul 15, 2022 – Jun 30, 2026 · Role: Principal Investigator
  • Estimating the Contribution of Alcohol and Metabolic Risk to Liver Disease Progression to Inform Personalized Interventions
    NIH · K23AA029752 · Jul 1, 2022 – Jun 30, 2026

Media

Publications

  • Patterns of Alcohol Use After Early Liver Transplantation for Alcoholic Hepatitis. Clin Gastroenterol Hepatol. 2022 02; 20(2):409-418.e5.. View in PubMed
  • Medicaid Policy and Liver Transplant for Alcohol-Associated Liver Disease. Hepatology. 2020 07; 72(1):130-139.. View in PubMed
  • Chronic Kidney Disease in Liver Transplant Candidates: A Rising Burden Impacting Post-Liver Transplant Outcomes. Liver Transpl. 2020 04; 26(4):498-506.. View in PubMed
  • Liver Transplantation in Unauthorized Immigrants in the United States. Hepatology. 2020 05; 71(5):1802-1812.. View in PubMed
  • Early Liver Transplantation for Alcohol-Associated Liver Disease: Need for Engagement and Education of All Stakeholders. Hepatol Commun. 2019 Aug; 3(8):1019-1021.. View in PubMed
  • Model to Calculate Harms and Benefits of Early vs Delayed Liver Transplantation for Patients With Alcohol-Associated Hepatitis. Gastroenterology. 2019 08; 157(2):472-480.e5.. View in PubMed
  • Underestimation of Liver Transplantation for Alcoholic Hepatitis in the National Transplant Database. Liver Transpl. 2019 05; 25(5):706-711.. View in PubMed
  • Liver-related mortality in the United States: hepatitis C declines, non-alcoholic fatty liver and alcohol rise. Transl Gastroenterol Hepatol. 2019; 4:19.. View in PubMed
  • Predicting Low Risk for Sustained Alcohol Use After Early Liver Transplant for Acute Alcoholic Hepatitis: The Sustained Alcohol Use Post-Liver Transplant Score. Hepatology. 2019 04; 69(4):1477-1487.. View in PubMed
  • National Trends and Long-term Outcomes of Liver Transplant for Alcohol-Associated Liver Disease in the United States. JAMA Intern Med. 2019 03 01; 179(3):340-348.. View in PubMed