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Cheng Ji, PhD

Professor of Research Medicine

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Phone +1 323 442 2224
Email [email protected]
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Overview

Dr. Ji joined the faculty of Keck School of Medicine of USC in September 2000. Prior to the faculty, he earned his M.S. in Chemistry from Shanghai Jiao Tong Univ. and completed his PhD in Biochemistry and postdoctoral fellowships in Pathology/Medicine at Univ. of California and Keck School of Medicine of USC, respectively. Dr. Ji’s research interests include cellular organelle (e.g., ER, Golgi, mitochondria, or lysosomes) stress and liver disease, alcohol-induced hyperhomocysteinemia, and hepatotoxicity of anti-viral drugs and substance use disorders. He was among the first discovered in vivo the association of ER stress response with development of liver disease. Dr. Ji has published original research papers in leading journals such as Gastroenterology, Journal of Hepatology, Hepatology, PNAS, Cell, Nature Nanotech. and Advanced Materials.

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Publications

  • Protective Effects of Emodin on Lung Injuries in Rat Models of Liver Fibrosis. Open Life Sci. 2019 Jan; 14:611-618.. View in PubMed
  • Protective Effects of Facilitated Removal of Blood Alcohol and Acetaldehyde Against Liver Injury in Animal Models Fed Alcohol and Anti-HIV Drugs. Alcohol Clin Exp Res. 2019 06; 43(6):1091-1102.. View in PubMed
  • Human Mesenchymal Stem Cell Derived Exosomes Alleviate Type 2 Diabetes Mellitus by Reversing Peripheral Insulin Resistance and Relieving β-Cell Destruction. ACS Nano. 2018 08 28; 12(8):7613-7628.. View in PubMed
  • A Hepatocyte-Mimicking Antidote for Alcohol Intoxication. Adv Mater. 2018 May; 30(22):e1707443.. View in PubMed
  • Effect of artesunate supplementation on bacterial translocation and dysbiosis of gut microbiota in rats with liver cirrhosis. World J Gastroenterol. 2016 Mar 14; 22(10):2949-59.. View in PubMed
  • Enhanced expression of glucose-regulated protein 78 correlates with malondialdehyde levels during the formation of liver cirrhosis in rats. Exp Ther Med. 2015 Dec; 10(6):2119-2125.. View in PubMed
  • Increased expression of 78 kD glucose-regulated protein promotes cardiomyocyte apoptosis in a rat model of liver cirrhosis. Int J Clin Exp Pathol. 2015; 8(8):9256-63.. View in PubMed
  • Advances and New Concepts in Alcohol-Induced Organelle Stress, Unfolded Protein Responses and Organ Damage. Biomolecules. 2015 Jun 03; 5(2):1099-121.. View in PubMed
  • Prevention of hepatitis C virus infection and spread in human liver chimeric mice by an anti-CD81 monoclonal antibody. Hepatology. 2015 Apr; 61(4):1136-44.. View in PubMed
  • Effects of combined alcohol and anti-HIV drugs on cellular stress responses in primary hepatocytes and hepatic stellate and kupffer cells. Alcohol Clin Exp Res. 2015 Jan; 39(1):11-20.. View in PubMed

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