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Cheng Ji, PhD

Professor of Research Medicine

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Phone +1 323 442 2224
Email [email protected]
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Overview

Dr. Ji joined the faculty of Keck School of Medicine of USC in September 2000. Prior to the faculty, he earned his M.S. in Chemistry from Shanghai Jiao Tong Univ. and completed his PhD in Biochemistry and postdoctoral fellowships in Pathology/Medicine at Univ. of California and Keck School of Medicine of USC, respectively. Dr. Ji’s research interests include cellular organelle (e.g., ER, Golgi, mitochondria, or lysosomes) stress and liver disease, alcohol-induced hyperhomocysteinemia, and hepatotoxicity of anti-viral drugs and substance use disorders. He was among the first discovered in vivo the association of ER stress response with development of liver disease. Dr. Ji has published original research papers in leading journals such as Gastroenterology, Journal of Hepatology, Hepatology, PNAS, Cell, Nature Nanotech. and Advanced Materials.

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Publications

  • Biomimetic enzyme nanocomplexes and their use as antidotes and preventive measures for alcohol intoxication. Nat Nanotechnol. 2013 Mar; 8(3):187-92.. View in PubMed
  • The effects of dietary fatty acid composition in the post-sucking period on metabolic alterations in adulthood: can ω3 polyunsaturated fatty acids prevent adverse programming outcomes? J Endocrinol. 2 . View in PubMed
  • Human immunodeficiency virus protease inhibitors modulate Ca2+ homeostasis and potentiate alcoholic stress and injury in mice and primary mouse and human hepatocytes. Hepatology. 2012 Aug; 56(2):594-604.. View in PubMed
  • Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology. 2012 Jul; 56(1):130-9.. View in PubMed
  • Investigation of chronic alcohol consumption in rodents via ultra-high-performance liquid chromatography-mass spectrometry based metabolite profiling. J Chromatogr A. 2012 Oct 12; 1259:128-37.. View in PubMed
  • Development of a multiplex UPLC-MRM MS method for quantification of human membrane transport proteins OATP1B1, OATP1B3 and OATP2B1 in in vitro systems and tissues. Anal Chim Acta. 2012 Mar 02; 717:67-76.. View in PubMed
  • Experimental SSM-CVB3 infection in macaques. Exp Mol Pathol. 2012 Feb; 92(1):131-9.. View in PubMed
  • Mechanisms of alcohol-induced endoplasmic reticulum stress and organ injuries. Biochem Res Int. 2012; 2012:216450.. View in PubMed
  • Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice. Hepatology. 2011 Jul; 54(1):229-39.. View in PubMed
  • Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells. J Biol Chem. 2011 Jun 24; 286(25):22047-54.. View in PubMed

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