Christopher Ching

Assistant Professor Of Research Neurology

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Overview

Dr. Ching is an Assistant Professor at The Imaging Genetics Center, part of the Mark and Mary Stevens Neuroimaging and Informatics Institute, where his research focuses on neuroimaging and genomic markers of psychiatric and neurodegenerative disorders. As a core organizing member of the Enhancing Neuro Imaging Genetics through Meta-Analysis Consortium (ENIGMA), he designs and implements standardized processing and analysis techniques for large-scale, international neuroimaging studies for a wide range of brain conditions. He leads the ENIGMA Bipolar Disorder Working Group, an effort including >200 researchers from around the world pooling data and resources to improve our understanding of the biological processes driving bipolar disorder. In complementary work, he studies rare copy number variants like 22q11.2 Deletion Syndrome to understand how certain rare genetic mutations can lead to increased risk for developing psychiatric illness. Finally, he leads several large-scale transdiagnostic neuroimaging and genomic initiatives mapping the common and distinct brain and clinical factors across a range of serious mental illnesses.

Awards

  • USC: Postdoctoral Fellowship in Biomarkers in Alzheimer’s Disease NIAT32AG058507, 2019
     – 2021
  • UCLA: Neurobehavioral Genetics Predoctoral Fellowship, NIH/NIMH 5T32MH073526, 2015
     – 2016
  • UCLA: Neuroimaging Training Program, National Institutes of Health, R90 DA022768 and T90 DA023422, 2012
     – 2013
  • UCLA: National Science Foundation Alliance for Graduate Education and the Professoriate Grant, 2012
     – 2012

Education and Training

  • UCLA — PhD — Neuroscience
  • Pomona College — BA — Neuroscience/Philosophy

Research Keywords

  • Neuroscience
  • Neuoroimaging
  • Psychiatric Disorders
  • Genetics
  • Neurodegenerative Disease

Publications

  • Cortical morphometry might predict currently prescribed vs. discontinued medications in bipolar disorder, even after controlling for the cumulative dose effects: An ENIGMA mega-analysis. Mol Psychiatry. 2026 Aug; 31(8):4418-4432.. View in PubMed
  • Dimensional Associations Between Conduct Problems and Brain Structure Across 18 International Cohorts in ENIGMA. J Am Acad Child Adolesc Psychiatry. 2026 Mar 13.. View in PubMed
  • Genetic insights on the mechanisms of human cortical folding. bioRxiv. 2026 Mar 09.. View in PubMed
  • The Link Between Weight Gain and Hippocampal Atrophy in Bipolar Disorder: A Longitudinal Investigation in 934 Participants. Biol Psychiatry. 2026 Feb 18.. View in PubMed
  • Brain aging in bipolar disorder using a neuroimaging and machine learning-derived metric: Findings from the ENIGMA BD Working Group. J Affect Disord. 2026 Jun 15; 403:121234.. View in PubMed
  • Charting Brain Structure in 22q11.2 Deletion Syndrome with Clinical Neuroimaging. medRxiv. 2026 Jan 23.. View in PubMed
  • Brain Age in Conduct Disorder:: A Mega-Analysis of the ENIGMA Antisocial Behavior Working Group. bioRxiv. 2026 Jan 21.. View in PubMed
  • Psychotropic medications and their interactions with subcortical brain volume in bipolar disorder: An ENIGMA mega-analysis. Mol Psychiatry. 2026 May; 31(5):2941-2953.. View in PubMed
  • Deterministic versus Probabilistic Tractography: Impact on White Matter Bundle Shape. bioRxiv. 2025 Nov 11.. View in PubMed
  • Brain morphology mediators of the link between childhood trauma and bipolar disorder: a large-scale international analysis. medRxiv. 2025 Nov 04.. View in PubMed