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Ebrahim Zandi, PhD

Associate Professor of Immunology and Immune Therapeutics

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Phone +1 323 865 0644
Email [email protected]
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Overview

Dr. Ebrahim (Ebi) Zandi is Associate Professor of Molecular Microbiology & immunology at USC Keck School of Medicine. He received his Ph.D. in Biochemistry in 1995 from the California Institute of Technology (CalTech, Pasadena, CA). He has made significant contributions to the field of NF-kB and IKK signal transduction pathways. He has been honored with several awards including Leukemia and Lymphoma Society of America Special Fellow Award, The V Foundation, and Stop Cancer. In addition, he is the first PEW Scholar Fellow (2001-2004) at USC. Furthermore, He has established Mass Spectrometry-based Proteomics at KSOM, and is the founding director of the USC Proteomics Center of Excellence. Currently, his research involves the use of proteomics and other omic technologies to understand the function of microbiome in Ulcerative Colitis as well as chemo- and immune-therapy in cancer patients.

Research Funding

  • Mechanisms of IkappaB Kinase Regulation
    NIH · R01GM065325 · Aug 1, 2002 – Jul 31, 2009 · Role: Principal Investigator

Publications

  • Consensus Risk Modeling and Uncertainty Quantification of Alzheimer’s Disease Using 5ADCSI Plasma Biomarkers and Multiple External Machine-Learning Frameworks. medRxiv. 2026 Aug 02.. View in PubMed
  • Second generation DNA methylation age predicts cognitive change in midlife: the moderating role of childhood socioeconomic status. Aging (Albany NY). 2025 07 23; 17(7):1702-1720.. View in PubMed
  • High precision and cost-effective multiplex quantification of amyloid-β40, amyloid-β42, p181Tau, p217Tau, neurofilament light chain, and glial fibrillary acidic protein from plasma and serum. J Alzheimers Dis. 2025 07; 106(2):739-755.. View in PubMed
  • Second Generation DNA Methylation Age Predicts Cognitive Change in Midlife: The Moderating Role of Childhood Socioeconomic Status. Res Sq. 2024 Dec 24.. View in PubMed
  • Epigenome-wide association study of loneliness in a sample of U.S. middle-aged twins. Epigenetics. 2024 12; 19(1):2427999.. View in PubMed
  • Midlife Study of the Louisville Twins: Connecting Cognitive Development to Biological and Cognitive Aging. Behav Genet. 2020 03; 50(2):73-83.. View in PubMed
  • Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-β signaling. Proc Natl Acad Sci U S A. 2018 05 01; 115(18):E4245-E4254.. View in PubMed
  • A perillyl alcohol-conjugated analog of 3-bromopyruvate without cellular uptake dependency on monocarboxylate transporter 1 and with activity in 3-BP-resistant tumor cells. Cancer Lett. 2017 08 01; 400:161-174.. View in PubMed
  • Multidimensional Separation Using HILIC and SCX Pre-fractionation for RP LC-MS/MS Platform with Automated Exclusion List-based MS Data Acquisition with Increased Protein Quantification. J Proteomics Bioinform. 2015 Nov; 8(11):260-265.. View in PubMed
  • Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis. Immunity. 2015 Aug 18; 43(2):251-63.. View in PubMed

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