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Ebrahim Zandi, PhD

Associate Professor of Immunology and Immune Therapeutics

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Phone +1 323 865 0644
Email [email protected]
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Overview

Dr. Ebrahim (Ebi) Zandi is Associate Professor of Molecular Microbiology & immunology at USC Keck School of Medicine. He received his Ph.D. in Biochemistry in 1995 from the California Institute of Technology (CalTech, Pasadena, CA). He has made significant contributions to the field of NF-kB and IKK signal transduction pathways. He has been honored with several awards including Leukemia and Lymphoma Society of America Special Fellow Award, The V Foundation, and Stop Cancer. In addition, he is the first PEW Scholar Fellow (2001-2004) at USC. Furthermore, He has established Mass Spectrometry-based Proteomics at KSOM, and is the founding director of the USC Proteomics Center of Excellence. Currently, his research involves the use of proteomics and other omic technologies to understand the function of microbiome in Ulcerative Colitis as well as chemo- and immune-therapy in cancer patients.

Research Funding

  • Mechanisms of IkappaB Kinase Regulation
    NIH · R01GM065325 · Aug 1, 2002 – Jul 31, 2009 · Role: Principal Investigator

Publications

  • Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs). J Med Chem. 2011 Apr 28; 54(8):2902-14.. View in PubMed
  • Novel function and intracellular localization of methionine adenosyltransferase 2beta splicing variants. J Biol Chem. 2010 Jun 25; 285(26):20015-21.. View in PubMed
  • DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis. DNA Repair (Amst). 2010 Apr 04; 9(4):429-37.. View in PubMed
  • Regulation of I(kappa)B kinase complex by phosphorylation of (gamma)-binding domain of I(kappa)B kinase (beta) by Polo-like kinase 1. J Biol Chem. 2008 Dec 19; 283(51):35354-67.. View in PubMed
  • A simple and inexpensive on-column frit fabrication method for fused-silica capillaries for increased capacity and versatility in LC-MS/MS applications. Proteomics. 2008 May; 8(9):1758-61.. View in PubMed
  • Identification of galectin-3-binding protein as a factor secreted by tumor cells that stimulates interleukin-6 expression in the bone marrow stroma. J Biol Chem. 2008 Jul 04; 283(27):18573-81.. View in PubMed
  • A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity. J Biol Chem. 2007 Jul 20; 282(29):21487-96.. View in PubMed
  • DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5′ or 3′ overhangs. J Biol Chem. 2006 Nov 10; 281(45):33900-9.. View in PubMed
  • TNFalpha induces chromosomal abnormalities independent of ROS through IKK, JNK, p38 and caspase pathways. Cytokine. 2006 Apr; 34(1-2):39-50.. View in PubMed
  • Regulation of IkappaB kinase (IKK) complex by IKKgamma-dependent phosphorylation of the T-loop and C terminus of IKKbeta. J Biol Chem. 2006 Jun 02; 281(22):15268-76.. View in PubMed

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