USC.edu
Are You a Patient?

Ebrahim Zandi, PhD

Associate Professor of Immunology and Immune Therapeutics

Image of Ebrahim Zandi, PhD
Is this your profile? Click to edit
Phone +1 323 865 0644
Email [email protected]
CTSI Profile

Overview

Dr. Ebrahim (Ebi) Zandi is Associate Professor of Molecular Microbiology & immunology at USC Keck School of Medicine. He received his Ph.D. in Biochemistry in 1995 from the California Institute of Technology (CalTech, Pasadena, CA). He has made significant contributions to the field of NF-kB and IKK signal transduction pathways. He has been honored with several awards including Leukemia and Lymphoma Society of America Special Fellow Award, The V Foundation, and Stop Cancer. In addition, he is the first PEW Scholar Fellow (2001-2004) at USC. Furthermore, He has established Mass Spectrometry-based Proteomics at KSOM, and is the founding director of the USC Proteomics Center of Excellence. Currently, his research involves the use of proteomics and other omic technologies to understand the function of microbiome in Ulcerative Colitis as well as chemo- and immune-therapy in cancer patients.

Research Funding

  • Mechanisms of IkappaB Kinase Regulation
    NIH · R01GM065325 · Aug 1, 2002 – Jul 31, 2009 · Role: Principal Investigator

Publications

  • An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction. PLoS Pathog. 2015 Jul; 11(7):e1005060.. View in PubMed
  • Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production. Mol Cell. 2015 Apr 02; 58(1):134-46.. View in PubMed
  • Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression. PLoS One. 2015; 10(2):e0117758.. View in PubMed
  • Activation of a novel c-Myc-miR27-prohibitin 1 circuitry in cholestatic liver injury inhibits glutathione synthesis in mice. Antioxid Redox Signal. 2015 Jan 20; 22(3):259-74.. View in PubMed
  • Hydrogen sulfide maintains mesenchymal stem cell function and bone homeostasis via regulation of Ca(2+) channel sulfhydration. Cell Stem Cell. 2014 Jul 03; 15(1):66-78.. View in PubMed
  • CAF-secreted annexin A1 induces prostate cancer cells to gain stem cell-like features. Mol Cancer Res. 2014 Apr; 12(4):607-21.. View in PubMed
  • Novel Phosphorylations of IKKγ/NEMO. mBio. 2012 Nov 06; 3(6):e00411-12.. View in PubMed
  • Site-specific modification of adeno-associated viruses via a genetically engineered aldehyde tag. Small. 2013 Feb 11; 9(3):421-9.. View in PubMed
  • Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16348-53.. View in PubMed
  • Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation. Cell Host Microbe. 2012 Mar 15; 11(3):264-76.. View in PubMed

Similar People