Frank Attenello, MD, MS

Associate Professor of Clinical Neurological Surgery and Cancer Biology

Sloan Family Endowed Professorship in Neurological Surgery

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Overview

Frank Attenello MD, MS is the Sloan Family Endowed Associate Professor of Neurosurgery, Biochemistry and Molecular Medicine at the Keck School of Medicine of USC, specializing in treatment of primary and metastatic brain tumors. He employs multiple surgical modalities to preserve neurologic function in tumor surgery including minimally invasive subcortical surgery (BrainPath) and laser interstitial thermal therapy. Dr. Attenello performs both cranial surgery and stereotactic radiosurgery.

Dr. Attenello received combined BS/MS degrees in Molecular Biochemistry and Biophysics from Yale University. He then received his medical degree from Johns Hopkins University School of Medicine, where he received the institutional Harvey Cushing Neurosurgery Award and the Ronald L. Bittner national Neuro-oncology research award. His work on glioblastoma and neural stem cells at Johns Hopkins was supported by a fellowship from the Howard Hughes Medical Institute. He then completed neurosurgical residency at the University of Southern California, with a postdoctoral fellowship in tumor genetics at the University of California, San Francisco.

Dr. Attenello has authored six neurosurgical book chapters and over 150 peer-reviewed manuscripts including articles in Science, BMJ, and Cancer Discovery. He was appointed Associate Scientific Advisor for Science Translational Medicine, and is an editorial board member of the Journal of Neurosurgery and the Journal of Neuroscience Research.

Dr. Attenello is also principal investigator of a basic science research laboratory studying epigenetic regulation of glioma chemoresistance as well as role of neural stem cells in brain injury (https://sites.usc.edu/attenellolab/). His laboratory is supported by a NIH K08 Research Career Development Award and several NIH and foundational grants, including generous patient support. In addition, Dr. Attenello directs a clinical outcomes laboratory studying factors associated with improved outcome in patients with neurologic disease, as well as factors driving medical trainee burnout. Using data and experience gained in the laboratory, Dr. Attenello is identifying new therapies for improved patient outcomes.

Education and Training

  • Johns Hopkins University School of Medicine, Baltimore, MD — MD — 05/2009 — Medicine
  • Yale University, New Haven, CT — BS, MS — 06/2003 — Molecular BIophysics and Biochemistry

Publications

  • Hypertensive Postpartum Admissions Among Women Without a History of Hypertension or Preeclampsia. Obstet Gynecol. 2019 04; 133(4):712-719.. View in PubMed
  • Early Readmission After Ventricular Shunting in Adults with Hydrocephalus: A Nationwide Readmission Database Analysis. World Neurosurg. 2019 Aug; 128:e38-e50.. View in PubMed
  • Postpartum readmissions among women with opioid use disorder. Am J Obstet Gynecol MFM. 2019 03; 1(1):89-98.. View in PubMed
  • Increased Hospital Surgical Volume Reduces Rate of 30- and 90-Day Readmission After Acoustic Neuroma Surgery. Neurosurgery. 2019 03 01; 84(3):726-732.. View in PubMed
  • Venous Thromboembolism After Degenerative Spine Surgery: A Nationwide Readmissions Database Analysis. World Neurosurg. 2019 05; 125:e165-e174.. View in PubMed
  • Readmission following inpatient stereotactic radiosurgery for brain tumors. J Radiosurg SBRT. 2019; 6(2):101-119.. View in PubMed
  • Predictors of Venous Thromboembolism After Nonemergent Craniotomy: A Nationwide Readmission Database Analysis. World Neurosurg. 2019 Feb; 122:e1102-e1110.. View in PubMed
  • Postpartum length of stay and risk for readmission among women with preeclampsia. J Matern Fetal Neonatal Med. 2020 Apr; 33(7):1086-1094.. View in PubMed
  • Treatment at Safety-Net Hospitals Is Associated with Delays in Coil Embolization in Patients with Subarachnoid Hemorrhage. World Neurosurg. 2018 Dec; 120:e434-e439.. View in PubMed
  • Predictors of Surgical Site Infection After Nonemergent Craniotomy: A Nationwide Readmission Database Analysis. World Neurosurg. 2018 Dec; 120:e440-e452.. View in PubMed