Keyue Shen

Associate Professor Biomedical Engineering

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Overview

Keyue Shen is an Associate Professor at the Department of Biomedical Engineering of USC Viterbi School of Engineering. He is a Full Member of the USC Norris Comprehensive Cancer Center. He received his Bachelor of Engineering in Mechanical Engineering (2001) and Master of Science in Biophysics (2004) from Tsinghua University of China. He earned his Ph.D. degree in Biomedical Engineering in the Department of Biomedical Engineering at Columbia University in 2010. He completed his postdoctoral training in the Center for Engineering in Medicine at Harvard Medical School and Massachusetts General Hospital (MGH), from 2010-2014. He joined the USC faculty in 2015.

Dr. Shen received an MGH Fund for Medical Discovery Award in 2012, a Broad Innovation Award in 2016, a Marni Levine Memorial Research Career Development Award from STOP CANCER in 2017, an NIH Trailblazer Award in 2017, and a Rising Star Award from the Biomedical Engineering Society-Cellular and Molecular Bioengineering Conference in 2020. His research interests are in developing in vitro microengineered models of hypoxic tumor microenvironments and stem cell niches for applications in immune and cancer therapeutics, imaging-based biomarkers for cancer and stem cells, and artificial intelligence (AI)-based models and approaches for clinical and basic research applications.

Research Funding

  • (PQ5) Microenvironmental Regulation of Mitochondrial Heterogeneity in Cancer Metastasis
    NIH · R01CA220012 · Sep 20, 2019 – Aug 31, 2024 · Role: Principal Investigator
  • Artificial Stromal Cell for Hematopoietic Stem Cell Expansion
    NIH · R21EB024748 · Aug 1, 2017 – Apr 30, 2021 · Role: Principal Investigator

Publications

  • Ultrasound priming gated by solid tumor hallmarks to guide CAR-T therapy. Sci Adv. 2026 Jun 12; 12(24):eaed0666.. View in PubMed
  • Tissue regenerative medicine: Clinical advances, challenges, and opportunities. APL Bioeng. 2025 Dec; 9(4):040902.. View in PubMed
  • Consensus guidelines for cellular label-free optical metabolic imaging: ensuring accuracy and reproducibility in metabolic profiling. J Biomed Opt. 2025 Feb; 30(Suppl 2):S23901.. View in PubMed
  • Precision Epigenetic Reprogramming: CoREST Inhibition Sensitizes STK11-Mutant Tumors to Immune Checkpoint Blockade Therapy. Cancer Res. 2025 10 15; 85(20):3821-3822.. View in PubMed
  • Microfabricated Organ-Specific Models of Tumor Microenvironments. Annu Rev Biomed Eng. 2025 05; 27(1):307-333.. View in PubMed
  • A micro-metabolic rewiring assay for assessing hypoxia-associated cancer metabolic heterogeneity. Bioact Mater. 2025 Jun; 48:493-509.. View in PubMed
  • Profiling paracrine interactions between hypoxic and normoxic skeletal muscle tissue in a microphysiological system fabricated from 3D printed components. Lab Chip. 2025 01 14; 25(2):212-224.. View in PubMed
  • Label-free metabolic optical biomarkers track stem cell fate transition in real time. Sci Adv. 2024 05 10; 10(19):eadi6770.. View in PubMed
  • Hypoxic 3D Tumor Model for Evaluating of CAR-T Cell Therapy In Vitro. Methods Mol Biol. 2024; 2748:119-134.. View in PubMed
  • Cleanroom-Free Microfluidic Device for Natural Induction of Hypoxia in 2D and 3D Tumor Models. Methods Mol Biol. 2024; 2755:227-247.. View in PubMed