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Keyue Shen

Associate Professor Biomedical Engineering

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Email [email protected]
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Overview

Keyue Shen is an Associate Professor at the Department of Biomedical Engineering of USC Viterbi School of Engineering. He is a Full Member of the USC Norris Comprehensive Cancer Center. He received his Bachelor of Engineering in Mechanical Engineering (2001) and Master of Science in Biophysics (2004) from Tsinghua University of China. He earned his Ph.D. degree in Biomedical Engineering in the Department of Biomedical Engineering at Columbia University in 2010. He completed his postdoctoral training in the Center for Engineering in Medicine at Harvard Medical School and Massachusetts General Hospital (MGH), from 2010-2014. He joined the USC faculty in 2015.

Dr. Shen received an MGH Fund for Medical Discovery Award in 2012, a Broad Innovation Award in 2016, a Marni Levine Memorial Research Career Development Award from STOP CANCER in 2017, an NIH Trailblazer Award in 2017, and a Rising Star Award from the Biomedical Engineering Society-Cellular and Molecular Bioengineering Conference in 2020. His research interests are in developing in vitro microengineered models of hypoxic tumor microenvironments and stem cell niches for applications in immune and cancer therapeutics, imaging-based biomarkers for cancer and stem cells, and artificial intelligence (AI)-based models and approaches for clinical and basic research applications.

Research Funding

  • (PQ5) Microenvironmental Regulation of Mitochondrial Heterogeneity in Cancer Metastasis
    NIH · R01CA220012 · Sep 20, 2019 – Aug 31, 2024 · Role: Principal Investigator
  • Artificial Stromal Cell for Hematopoietic Stem Cell Expansion
    NIH · R21EB024748 · Aug 1, 2017 – Apr 30, 2021 · Role: Principal Investigator

Publications

  • Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays. Nat Commun. 2014 Dec 09; 5:5662.. View in PubMed
  • Modulation of cellular stress response via the erythropoietin/CD131 heteroreceptor complex in mouse mesenchymal-derived cells. J Mol Med (Berl). 2015 Feb; 93(2):199-210.. View in PubMed
  • CD28 and CD3 have complementary roles in T-cell traction forces. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2241-6.. View in PubMed
  • Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobility. Mol Cell Biol. 2014 Mar; 34(6):955-64.. View in PubMed
  • Substrate rigidity regulates human T cell activation and proliferation. J Immunol. 2012 Aug 01; 189(3):1330-9.. View in PubMed
  • Self-aligned supported lipid bilayers for patterning the cell-substrate interface. J Am Chem Soc. 2009 Sep 23; 131(37):13204-5.. View in PubMed
  • Nanoengineering of Immune Cell Function. Mater Res Soc Symp Proc. 2009 Jan 01; 1209.. View in PubMed
  • Microcontact printing of proteins for cell biology. J Vis Exp. 2008 Dec 05.. View in PubMed
  • Micropatterning of costimulatory ligands enhances CD4+ T cell function. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7791-6.. View in PubMed
  • Local presentation of L1 and N-cadherin in multicomponent, microscale patterns differentially direct neuron function in vitro. Dev Neurobiol. 2007 Nov; 67(13):1765-76.. View in PubMed

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