Keyue Shen

Associate Professor Biomedical Engineering

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Overview

Keyue Shen is an Associate Professor at the Department of Biomedical Engineering of USC Viterbi School of Engineering. He is a Full Member of the USC Norris Comprehensive Cancer Center. He received his Bachelor of Engineering in Mechanical Engineering (2001) and Master of Science in Biophysics (2004) from Tsinghua University of China. He earned his Ph.D. degree in Biomedical Engineering in the Department of Biomedical Engineering at Columbia University in 2010. He completed his postdoctoral training in the Center for Engineering in Medicine at Harvard Medical School and Massachusetts General Hospital (MGH), from 2010-2014. He joined the USC faculty in 2015.

Dr. Shen received an MGH Fund for Medical Discovery Award in 2012, a Broad Innovation Award in 2016, a Marni Levine Memorial Research Career Development Award from STOP CANCER in 2017, an NIH Trailblazer Award in 2017, and a Rising Star Award from the Biomedical Engineering Society-Cellular and Molecular Bioengineering Conference in 2020. His research interests are in developing in vitro microengineered models of hypoxic tumor microenvironments and stem cell niches for applications in immune and cancer therapeutics, imaging-based biomarkers for cancer and stem cells, and artificial intelligence (AI)-based models and approaches for clinical and basic research applications.

Research Funding

  • (PQ5) Microenvironmental Regulation of Mitochondrial Heterogeneity in Cancer Metastasis
    NIH · R01CA220012 · Sep 20, 2019 – Aug 31, 2024 · Role: Principal Investigator
  • Artificial Stromal Cell for Hematopoietic Stem Cell Expansion
    NIH · R21EB024748 · Aug 1, 2017 – Apr 30, 2021 · Role: Principal Investigator

Publications

  • Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity. Adv Sci (Weinh). 2024 02; 11(5):e2300509.. View in PubMed
  • Quantifying COVID-19 policy impacts on subjective well-being during the early phase of the pandemic: A cross-sectional analysis of United States survey data from March to August 2020. PLoS One. 2023; 18(9):e0291494.. View in PubMed
  • Intracellular and microenvironmental regulation of mitochondrial membrane potential in cancer cells. WIREs Mech Dis. 2023 May-Jun; 15(3):e1595.. View in PubMed
  • Recapitulating Tumor Hypoxia in a Cleanroom-Free, Liquid-Pinning-Based Microfluidic Tumor Model. ACS Biomater Sci Eng. 2022 07 11; 8(7):3107-3121.. View in PubMed
  • Manipulation and Mechanical Deformation of Leukemia Cells by High-Frequency Ultrasound Single Beam. IEEE Trans Ultrason Ferroelectr Freq Control. 2022 06; 69(6):1889-1897.. View in PubMed
  • A Pillar-Free Diffusion Device for Studying Chemotaxis on Supported Lipid Bilayers. Micromachines (Basel). 2021 Oct 16; 12(10).. View in PubMed
  • E-Cadherin Regulates Mitochondrial Membrane Potential in Cancer Cells. Cancers (Basel). 2021 Oct 09; 13(20).. View in PubMed
  • Engineering a Vascularized Hypoxic Tumor Model for Therapeutic Assessment. Cells. 2021 08 26; 10(9).. View in PubMed
  • Membrane-bound SCF and VCAM-1 synergistically regulate the morphology of hematopoietic stem cells. J Cell Biol. 2021 10 04; 220(10).. View in PubMed
  • Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Rep. 2021 Jul 27; 36(4):109475.. View in PubMed