Mark S. Borchert, MD

Clinical Professor of Ophthalmology (Part-Time)

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Overview

Mark S. Borchert, MD earned a medical degree from Baylor College of Medicine. He completed his residency in the Department of Ophthalmology, University of Southern California, and a fellowship in neuro-ophthalmology at the Massachusetts Eye & Ear Infirmary, Harvard University. Dr. Borchert is the Director of Eye Birth Defects, leading the world’s largest study into optic nerve hypoplasia. Dr. Borchert, who has been listed in “Best Doctors in America,” also has received honors from the Pan American Association of Ophthalmology, the American Academy of Ophthalmology, and Society of Heed Fellows, as well as several teaching awards from the Keck School of Medicine. His research on the development of the retina and optic nerve in rats was part of an experiment on the NASA space shuttle.

Borchert investigates the development of the optic nerve and its retinotopic connections in the tectum (part of the midbrain) and thalamus (part of the forebrain). He is interested in the role that inaccurate or inadequate development of these connections plays in the pathogenesis of optic nerve hypoplasia, the leading cause of blindness in infants in the United states and Europe. His research focus also includes developing diagnostic tools using spectroscopic methods in the measurement of glucose levels in the eye.

Awards

  • Keck School of Medicine of USC: Resident Teaching Award, 1991
     – 1994
  • Keck School of Medicine of USC: Senior Resident Teaching Award, 1994
  • Keck School of Medicine of USC: Resident Teaching Award, 1996
  • Keck School of Medicine of USC: Resident Teaching Award, 1999
  • Keck School of Medicine of USC: Resident Teaching Award, 2001
  • American Academy of Ophthalmology: Achievement Award, 2002
  • America’s Top Doctors, 2006
     – 2009
  • Best Doctors in America Award, 2006
  • Pasadena Magazine Top Doctors Award, 2008
  • LA Magazine Best Doctors in Southern California, 2009
  • Best Doctors in America Award, 2009
  • LA Magazine: Super Doctors Award, 2010
  • Pasadena Magazine Top Doctors Award, 2010
  • Pasadena Magazine Top Doctors Award, 2013
     – 2014

Education and Training

  • Baylor College of Medicine — MD — 1983
  • USC Roski Eye Institute — Ophthalmology Residency — 1987
  • Massachusetts Eye & Ear Infirmary — Neuro-Ophthalmology Fellowship — 1988

Publications

  • COG5-congenital disorder of glycosylation diagnosed by whole genome sequencing in siblings with unexplained optic atrophy, macular atrophy, and developmental delay: case report. Front Neurol. 2026; 17:1840802.. View in PubMed
  • Validity and Reliability of the CVI Range for Clinical Research: Baseline and One-Year Results. Ophthalmol Sci. 2026 Jul; 6(7):101233.. View in PubMed
  • Generative Artificial Intelligence-Enabled Saliency Analysis of Eye Tracking in Cerebral/Cortical Visual Impairment (SET-CVI). Ophthalmol Sci. 2026 Apr; 6(4):101081.. View in PubMed
  • Trio exome sequencing of an optic nerve hypoplasia cohort reveals evidence for polygenic architecture. Ophthalmic Genet. 2025 12; 46(6):581-593.. View in PubMed
  • Vision-Specific Quality of Life in Children With Cortical or Cerebral Visual Impairment. J Vis Impair Blind. 2025 Jul-Aug; 119(4):256-265.. View in PubMed
  • Agreement and Accuracy of Papilledema and Pseudopapilledema Classification Among Pediatric Neuro-Ophthalmologists Using Optic Disc Photographs. J Neuroophthalmol. 2025 Dec 01; 45(4):433-439.. View in PubMed
  • Cerebral/Cortical Visual Impairment Classification and Categorization Using Eye Tracking Measures of Oculomotor Function. Ophthalmol Sci. 2025 May-Jun; 5(3):100728.. View in PubMed
  • Adaptive functioning and relationship to visual behavior in children with cerebral/cortical visual impairment. J AAPOS. 2025 02; 29(1):104107.. View in PubMed
  • Method for assessing visual saliency in children with cerebral/cortical visual impairment using generative artificial intelligence. Front Hum Neurosci. 2024; 18:1506286.. View in PubMed
  • Reply. Ophthalmology. 2025 Apr; 132(4):e65.. View in PubMed