Keck School Faculty

Mark S Borchert, MD
Mark S Borchert, MD
Clinical Associate Professor of Ophthalmology (Part-Time)
Pediatrics
CHL Mail Stop 88 Off Campus Los Angeles
Mark S. Borchert, MD earned a medical degree from Baylor College of Medicine. He completed his residency in the Department of Ophthalmology, University of Southern California, and a fellowship in neuro-ophthalmology at the Massachusetts Eye & Ear Infirmary, Harvard University. Dr. Borchert is the Director of Eye Birth Defects, leading the world’s largest study into optic nerve hypoplasia. Dr. Borchert, who has been listed in “Best Doctors in America,” also has received honors from the Pan American Association of Ophthalmology, the American Academy of Ophthalmology, and Society of Heed Fellows, as well as several teaching awards from the Keck School of Medicine. His research on the development of the retina and optic nerve in rats was part of an experiment on the NASA space shuttle.

Borchert investigates the development of the optic nerve and its retinotopic connections in the tectum (part of the midbrain) and thalamus (part of the forebrain). He is interested in the role that inaccurate or inadequate development of these connections plays in the pathogenesis of optic nerve hypoplasia, the leading cause of blindness in infants in the United states and Europe. His research focus also includes developing diagnostic tools using spectroscopic methods in the measurement of glucose levels in the eye.

: Pasadena Magazine Top Doctors Award, 2013-2014

: Pasadena Magazine Top Doctors Award, 2010

LA Magazine: Super Doctors Award, 2010

: Best Doctors in America Award, 2009

: LA Magazine Best Doctors in Southern California, 2009

: Pasadena Magazine Top Doctors Award, 2008

: America's Top Doctors, 2006-2009

: Best Doctors in America Award, 2006

American Academy of Ophthalmology: Achievement Award, 2002

Keck School of Medicine of USC: Resident Teaching Award, 2001

Keck School of Medicine of USC: Resident Teaching Award, 1999

Keck School of Medicine of USC: Resident Teaching Award, 1996

Keck School of Medicine of USC: Senior Resident Teaching Award, 1994

Keck School of Medicine of USC: Resident Teaching Award, 1991-1994

Factors Associated With Lack of Vision Improvement in Children With Cortical Visual Impairment J Neuroophthalmol. 2018 Dec; 38(4):429-433. . View in PubMed

Decreased severity of age-related macular degeneration in amblyopic eyes Br J Ophthalmol. 2018 Nov; 102(11):1575-1578. . View in PubMed

Decreased severity of age-related macular degeneration in amblyopic eyes Br J Ophthalmol. 2018 Feb 06. . View in PubMed

Factors Associated With Lack of Vision Improvement in Children With Cortical Visual Impairment J Neuroophthalmol. 2017 Dec 08. . View in PubMed

Pediatric Optic Neuritis: What Is New J Neuroophthalmol. 2017 Sep; 37 Suppl 1:S14-S22. . View in PubMed

Predictive value of N95 waveforms of pattern electroretinograms (PERGs) in children with optic nerve hypoplasia (ONH) Doc Ophthalmol. 2017 10; 135(2):97-106. . View in PubMed

Pediatric Optic Neuritis: What Is New J Neuroophthalmol. 2017 09; 37 Suppl 1:S14-S22. . View in PubMed

Brain Malformations Do Not Predict Hypopituitarism in Young Children with Optic Nerve Hypoplasia Horm Res Paediatr. 2017; 88(3-4):251-257. . View in PubMed

Strabismus in patients with cortical visual impairment: outcomes of surgery and observations of spontaneous resolution J AAPOS. 2016 Apr; 20(2):121-5. . View in PubMed

The Optic Nerve Hypoplasia Spectrum: Review of the Literature and Clinical Guidelines Adv Pediatr. 2016 08; 63(1):127-46. . View in PubMed

An evaluation of the safety and efficacy of bimatoprost for eyelash growth in pediatric subjects Clin Ophthalmol. 2016; 10:419-29. . View in PubMed

Efficacy of growth hormone replacement on anthropometric outcomes, obesity, and lipids in children with optic nerve hypoplasia and growth hormone deficiency Int J Pediatr Endocrinol. 2016; 2016:5. . View in PubMed

Fanfare for the Uncommon Neuro-Ophthalmologist: A Tribute to Irma Miller Lessell J Neuroophthalmol. 2015 Sep; 35(3):e24-5. . View in PubMed

Comparison of human expert and computer-automated systems using magnitude-squared coherence (MSC) and bootstrap distribution statistics for the interpretation of pattern electroretinograms (PERGs) in infants with optic nerve hypoplasia (ONH) Doc Ophthalmol. 2015 Aug; 131(1):25-34. . View in PubMed

Hypothalamic dysfunction without hamartomas causing gelastic seizures in optic nerve hypoplasia J Child Neurol. 2015 Feb; 30(2):233-7. . View in PubMed

Absence of age-related optic disk changes in young children with optic nerve hypoplasia Eye (Lond). 2014 May; 28(5):562-6. . View in PubMed

Re: Ramakrishnaiah et al: Reliability of magnetic resonance imaging for the detection of hypopituitarism in children with optic nerve hypoplasia (Ophthalmology 2014;121:387-91). Ophthalmology. 2014 May; 121(5):e26-7. . View in PubMed

Autism assessment in children with optic nerve hypoplasia and other vision impairments Dev Med Child Neurol. 2014 Jan; 56(1):66-72. . View in PubMed

Prenatal determinants of optic nerve hypoplasia: review of suggested correlates and future focus Surv Ophthalmol. 2013 Nov-Dec; 58(6):610-9. . View in PubMed

Failure of stem cell therapy to improve visual acuity in children with optic nerve hypoplasia J AAPOS. 2013 Oct; 17(5):490-3. . View in PubMed

Prevalence of amblyopia or strabismus in asian and non-Hispanic white preschool children: multi-ethnic pediatric eye disease study Ophthalmology. 2013 Oct; 120(10):2117-24. . View in PubMed

Prevalence of myopia, hyperopia, and astigmatism in non-Hispanic white and Asian children: multi-ethnic pediatric eye disease study Ophthalmology. 2013 Oct; 120(10):2109-16. . View in PubMed

Prevalence and causes of visual impairment in Asian and non-Hispanic white preschool children: Multi-ethnic Pediatric Eye Disease Study Ophthalmology. 2013 Jun; 120(6):1220-6. . View in PubMed

Optic nerve hypoplasia syndrome: a review of the epidemiology and clinical associations Curr Treat Options Neurol. 2013 Feb; 15(1):78-89. . View in PubMed

Newborn thyroid-stimulating hormone in children with optic nerve hypoplasia: associations with hypothyroidism and vision J AAPOS. 2012 Oct; 16(5):418-23. . View in PubMed

ATOH7 mutations cause autosomal recessive persistent hyperplasia of the primary vitreous Hum Mol Genet. 2012 Aug 15; 21(16):3681-94. . View in PubMed

Reappraisal of the optic nerve hypoplasia syndrome J Neuroophthalmol. 2012 Mar; 32(1):58-67. . View in PubMed

Serum prolactin concentrations in relation to hypopituitarism and obesity in children with optic nerve hypoplasia Horm Res Paediatr. 2012; 77(5):277-80. . View in PubMed

Presenting features and long-term effects of growth hormone treatment of children with optic nerve hypoplasia/septo-optic dysplasia Int J Pediatr Endocrinol. 2011 Nov 15; 2011(1):17. . View in PubMed

Risk factors for decreased visual acuity in preschool children: the multi-ethnic pediatric eye disease and Baltimore pediatric eye disease studies Ophthalmology. 2011 Nov; 118(11):2262-73. . View in PubMed

Risk factors associated with childhood strabismus: the multi-ethnic pediatric eye disease and Baltimore pediatric eye disease studies Ophthalmology. 2011 Nov; 118(11):2251-61. . View in PubMed

Risk factors for astigmatism in preschool children: the multi-ethnic pediatric eye disease and Baltimore pediatric eye disease studies Ophthalmology. 2011 Oct; 118(10):1974-81. . View in PubMed

Risk factors for hyperopia and myopia in preschool children the multi-ethnic pediatric eye disease and Baltimore pediatric eye disease studies Ophthalmology. 2011 Oct; 118(10):1966-73. . View in PubMed

Neurocognitive outcomes in pediatric and adolescent patients with central nervous system germinoma treated with a strategy of chemotherapy followed by reduced-dose and volume irradiation Pediatr Blood Cancer. 2011 Oct; 57(4):669-73. . View in PubMed

General health-related quality of life in preschool children with strabismus or amblyopia Ophthalmology. 2011 Mar; 118(3):574-80. . View in PubMed

Prevalence of astigmatism in 6- to 72-month-old African American and Hispanic children: the Multi-ethnic Pediatric Eye Disease Study Ophthalmology. 2011 Feb; 118(2):284-93. . View in PubMed

Prevalence and risk factors for disrupted circadian rhythmicity in children with optic nerve hypoplasia Br J Ophthalmol. 2010 Oct; 94(10):1358-62. . View in PubMed

Optic nerve hypoplasia in North America: a re-appraisal of perinatal risk factors Acta Ophthalmol. 2010 Aug; 88(5):527-34. . View in PubMed

Clinical electrophysiology and visual outcome in optic nerve hypoplasia Br J Ophthalmol. 2010 Aug; 94(8):1017-23. . View in PubMed

Anisometropia in Hispanic and african american infants and young children the multi-ethnic pediatric eye disease studyOphthalmology. 2010 Jan; 117(1):148-153. e1. . View in PubMed

Evolving central hypothyroidism in children with optic nerve hypoplasia J Pediatr Endocrinol Metab. 2010 Jan-Feb; 23(1-2):53-8. . View in PubMed

Light-adapted electroretinograms in optic nerve hypoplasia Doc Ophthalmol. 2009 Oct; 119(2):123-32. . View in PubMed

Visual acuity norms in pre-school children: the Multi-Ethnic Pediatric Eye Disease Study Optom Vis Sci. 2009 Jun; 86(6):607-12. . View in PubMed

Fixation preference and visual acuity testing in a population-based cohort of preschool children with amblyopia risk factors Ophthalmology. 2009 Jan; 116(1):145-53. . View in PubMed

The syndrome of optic nerve hypoplasia Curr Neurol Neurosci Rep. 2008 Sep; 8(5):395-403. . View in PubMed

Testability of the Retinomax autorefractor and IOLMaster in preschool children: the Multi-ethnic Pediatric Eye Disease StudyOphthalmology. 2008 Aug; 115(8):1422-5, 1425. e1. . View in PubMed

Long-term outcomes of pediatric ocular myasthenia gravisOphthalmology. 2008 Jul; 115(7):1245-1248. e1. . View in PubMed

Pediatric optic neuritis J Med Assoc Thai. 2008 Mar; 91(3):323-30. . View in PubMed

Neuroradiographic, endocrinologic, and ophthalmic correlates of adverse developmental outcomes in children with optic nerve hypoplasia: a prospective study Pediatrics. 2008 Mar; 121(3):e653-9. . View in PubMed

Stereoacuity testability in African-American and Hispanic pre-school children Optom Vis Sci. 2008 Mar; 85(3):158-63. . View in PubMed

Optic nerve hypoplasia and hypopituitarism Pediatr Endocrinol Rev. 2008 Mar; 5(3):772-7. . View in PubMed

Visual acuity testability in African-American and Hispanic children: the multi-ethnic pediatric eye disease study Am J Ophthalmol. 2007 Nov; 144(5):663-7. . View in PubMed

Retinal function in infants with optic nerve hypoplasia: electroretinograms to large patterns and photopic flash Eye (Lond). 2007 Jun; 21(6):712-20. . View in PubMed

Prolonged pancytopenia in a gene therapy patient with ADA-deficient SCID and trisomy 8 mosaicism: a case report Blood. 2007 Jan 15; 109(2):503-6. . View in PubMed

Measurement of amphotericin B concentration by resonant Raman spectroscopy--a novel technique that may be useful for non-invasive monitoring Med Mycol. 2006 Mar; 44(2):169-74. . View in PubMed

Endocrinological and auxological abnormalities in young children with optic nerve hypoplasia: a prospective study J Pediatr. 2006 Jan; 148(1):78-84. . View in PubMed

Validation of ICNIRP estimates of toxicity thresholds for NIR (785 nm) light in the retinas of pigmented rabbits Health Phys. 2006 Jan; 90(1):3-10. . View in PubMed

Determination of glucose in human aqueous humor using Raman spectroscopy and designed-solution calibration Appl Spectrosc. 2005 Aug; 59(8):1024-31. . View in PubMed

Glucose determination in human aqueous humor with Raman spectroscopy J Biomed Opt. 2005 May-Jun; 10(3):031110. . View in PubMed

Opsoclonus-ataxia caused by childhood neuroblastoma: developmental and neurologic sequelae Pediatrics. 2002 Jan; 109(1):86-98. . View in PubMed

Clinical diversity of hereditary Duane's retraction syndrome Ophthalmology. 2000 Mar; 107(3):500-3. . View in PubMed

Localization of a gene for Duane retraction syndrome to chromosome 2q31 Am J Hum Genet. 1999 Dec; 65(6):1639-46. . View in PubMed

The relationship between stereopsis and monocular optokinetic optokinetic nystagmus after infantile cataracts J AAPOS. 1999 Aug; 3(4):221-6. . View in PubMed

Exclusion of candidate genetic loci for Duane retraction syndrome Am J Ophthalmol. 1999 Mar; 127(3):358-60. . View in PubMed

Idiopathic intracranial hypertension in prepubertal pediatric patients: characteristics, treatment, and outcome Am J Ophthalmol. 1999 Feb; 127(2):178-82. . View in PubMed

A noninvasive glucose monitor: preliminary results in rabbits Diabetes Technol Ther. 1999; 1(2):145-51. . View in PubMed

Grand rounds #53: A case of small angle strabismus, torsion, aniseikonia and diplopia associated with epiretinal membranes [clincical conference] Binocul Vis Strabismus Q. 1999; 14(1):46-51; discussion 51-2. . View in PubMed

Open globe injuries in children J AAPOS. 1998 Aug; 2(4):234-8. . View in PubMed

Visual outcome in high hypermetropia J AAPOS. 1997 Sep; 1(3):147-50. . View in PubMed

Etiology and prognosis of acute, late-onset esotropia Ophthalmology. 1997 Aug; 104(8):1348-52. . View in PubMed

Comparisons of contact lens, foil, fiber and skin electrodes for patterns electroretinograms Doc Ophthalmol. 1997-1998; 94(4):327-40. . View in PubMed

Hemifield slide diplopia from altitudinal visual field defects J Neuroophthalmol. 1996 Jun; 16(2):107-9. . View in PubMed

Clinical assessment, optic disk measurements, and visual-evoked potential in optic nerve hypoplasia Am J Ophthalmol. 1995 Nov; 120(5):605-12. . View in PubMed

Independence of optokinetic nystagmus asymmetry and binocularity in infantile esotropia Arch Ophthalmol. 1994 Dec; 112(12):1580-3. . View in PubMed

Etiology of eyelid retraction in children: a retrospective study J Pediatr Ophthalmol Strabismus. 1993 Mar-Apr; 30(2):96-9. . View in PubMed

Ocular findings in neonates after extracorporeal membrane oxygenation Retina. 1993; 13(3):202-7. . View in PubMed

Position-dependent Parinaud's syndrome Am J Ophthalmol. 1992 Jul 15; 114(1):107-8. . View in PubMed

Third nerve palsy due to cerebral artery aneurysm in a child Aust N Z J Ophthalmol. 1992 May; 20(2):137-40. . View in PubMed

Chronic ocular ischemia and neovascular glaucoma: a result of extracranial carotid artery disease J Vasc Surg. 1988 Nov; 8(5):551-7. . View in PubMed

Progressive and recurrent nonarteritic anterior ischemic optic neuropathy Am J Ophthalmol. 1988 Oct 15; 106(4):443-9. . View in PubMed

Bright light stimuli as a mask of relative afferent pupillary defects Am J Ophthalmol. 1988 Jul 15; 106(1):98-9. . View in PubMed

Hypopyon keratouveitis in acute angle-closure glaucoma Am J Ophthalmol. 1987 Oct 15; 104(4):430-1. . View in PubMed

Assessment of visual impairment in patients with Alzheimer's disease Am J Ophthalmol. 1987 Aug 15; 104(2):113-20. . View in PubMed

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