Mark S. Borchert, MD

Clinical Professor of Ophthalmology (Part-Time)

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Overview

Mark S. Borchert, MD earned a medical degree from Baylor College of Medicine. He completed his residency in the Department of Ophthalmology, University of Southern California, and a fellowship in neuro-ophthalmology at the Massachusetts Eye & Ear Infirmary, Harvard University. Dr. Borchert is the Director of Eye Birth Defects, leading the world’s largest study into optic nerve hypoplasia. Dr. Borchert, who has been listed in “Best Doctors in America,” also has received honors from the Pan American Association of Ophthalmology, the American Academy of Ophthalmology, and Society of Heed Fellows, as well as several teaching awards from the Keck School of Medicine. His research on the development of the retina and optic nerve in rats was part of an experiment on the NASA space shuttle.

Borchert investigates the development of the optic nerve and its retinotopic connections in the tectum (part of the midbrain) and thalamus (part of the forebrain). He is interested in the role that inaccurate or inadequate development of these connections plays in the pathogenesis of optic nerve hypoplasia, the leading cause of blindness in infants in the United states and Europe. His research focus also includes developing diagnostic tools using spectroscopic methods in the measurement of glucose levels in the eye.

Awards

  • Keck School of Medicine of USC: Resident Teaching Award, 1991
     – 1994
  • Keck School of Medicine of USC: Senior Resident Teaching Award, 1994
  • Keck School of Medicine of USC: Resident Teaching Award, 1996
  • Keck School of Medicine of USC: Resident Teaching Award, 1999
  • Keck School of Medicine of USC: Resident Teaching Award, 2001
  • American Academy of Ophthalmology: Achievement Award, 2002
  • America’s Top Doctors, 2006
     – 2009
  • Best Doctors in America Award, 2006
  • Pasadena Magazine Top Doctors Award, 2008
  • LA Magazine Best Doctors in Southern California, 2009
  • Best Doctors in America Award, 2009
  • LA Magazine: Super Doctors Award, 2010
  • Pasadena Magazine Top Doctors Award, 2010
  • Pasadena Magazine Top Doctors Award, 2013
     – 2014

Education and Training

  • Baylor College of Medicine — MD — 1983
  • USC Roski Eye Institute — Ophthalmology Residency — 1987
  • Massachusetts Eye & Ear Infirmary — Neuro-Ophthalmology Fellowship — 1988

Publications

  • Special Commentary: Cerebral/Cortical Visual Impairment Working Definition: A Report from the National Institutes of Health CVI Workshop. Ophthalmology. 2024 12; 131(12):1359-1365.. View in PubMed
  • Disparities in Amblyopia Treatment Outcomes: The Impact of Sociodemographic Factors, Treatment Compliance, and Age of Diagnosis. Ophthalmology. 2025 03; 132(3):335-342.. View in PubMed
  • Evaluating Atypical Gaze Patterns through Vision Models: The Case of Cortical Visual Impairment. Annu Int Conf IEEE Eng Med Biol Soc. 2024 Jul; 2024:1-5.. View in PubMed
  • Autosomal Recessive Leber Hereditary Optic Neuropathy Triggered by Superior Mesenteric Artery Syndrome. J Neuroophthalmol. 2025 Mar 01; 45(1):e71-e73.. View in PubMed
  • Aberrant gene expression yet undiminished retinal ganglion cell genesis in iPSC-derived models of optic nerve hypoplasia. Ophthalmic Genet. 2024 02; 45(1):1-15.. View in PubMed
  • An unexpected turn: a case of torsional anomalous retinal correspondence after myectomy of previously anteriorized inferior oblique muscles in a child. J AAPOS. 2024 02; 28(1):103820.. View in PubMed
  • Supracerebellar infratentorial resection of a torcular lesion causing fulminant intracranial hypertension: illustrative case. J Neurosurg Case Lessons. 2023 Dec 18; 6(25).. View in PubMed
  • Comparison of Eye Tracking and Teller Acuity Cards for Visual Acuity Assessment in Pediatric Cortical/Cerebral Visual Impairment. Am J Ophthalmol. 2024 04; 260:115-121.. View in PubMed
  • Preretinal Hemorrhage in Myelin Oligodendrocyte Glycoprotein-Associated Disease. Ophthalmol Retina. 2023 12; 7(12):1108.. View in PubMed
  • Giant Dacryops in a 4-year-old Child. Ophthalmology. 2024 07; 131(7):835.. View in PubMed