Michael Bienkowski, PhD

Assistant Professor of Physiology and Neuroscience and Biomedical Engineering

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Overview

Dr. Bienkowski is interested in characterizing brain cell types and understanding their susceptibility to neurodegenerative diseases like Alhzeimer’s disease and retinal degenerative diseases. His translational research laboratory (USC Center for Integrative Connectomics) uses state-of-the-art connectomics and transcriptomics approaches to investigate cell type-specific progressive changes to gene expression and connectivity in rodent and human brain tissue. A major goal of the lab is to build translational cell type atlases to guide clinical drug development and enhance the effectiveness of treatment plans at progressive disease stages.

Research Funding

  • Multiscale Modeling of Hippocampus Vulnerability to Alzheimer's Disease Neurodegeneration.
    NIH · R01AG092662 · Jan 1, 2026 – Dec 31, 2030 · Role: Principal Investigator
  • A Translational 3D Map of Hippocampal Cell Types To Drive Investigations of Alzheimer's Disease
    NIH · K01AG066847 · Aug 1, 2021 – Jul 31, 2026 · Role: Principal Investigator
  • Alzheimer's Disease Research Centers
    NIH · P30AG066530 · Sep 1, 2020 – Mar 31, 2030 · Role: Co-Principal Investigator
  • Structural and Functional Neural Network Mediating Fear Memory and PTSD
    NIH · F32MH107071 · Sep 16, 2015 – Sep 15, 2017 · Role: Principal Investigator

Publications

  • Connectivity characterization of the mouse basolateral amygdalar complex. Nat Commun. 2021 05 17; 12(1):2859.. View in PubMed
  • Homologous laminar organization of the mouse and human subiculum. Sci Rep. 2021 02 12; 11(1):3729.. View in PubMed
  • An open access mouse brain flatmap and upgraded rat and human brain flatmaps based on current reference atlases. J Comp Neurol. 2021 02; 529(3):576-594.. View in PubMed
  • Precise segmentation of densely interweaving neuron clusters using G-Cut. Nat Commun. 2019 04 04; 10(1):1549.. View in PubMed
  • Extrastriate connectivity of the mouse dorsal lateral geniculate thalamic nucleus. J Comp Neurol. 2019 05 15; 527(9):1419-1442.. View in PubMed
  • Integration of gene expression and brain-wide connectivity reveals the multiscale organization of mouse hippocampal networks. Nat Neurosci. 2018 11; 21(11):1628-1643.. View in PubMed
  • The mouse cortico-striatal projectome. Nat Neurosci. 2016 08; 19(8):1100-14.. View in PubMed
  • Neural networks of the mouse neocortex. Cell. 2014 Feb 27; 156(5):1096-111.. View in PubMed
  • Organization of multisynaptic circuits within and between the medial and the central extended amygdala. J Comp Neurol. 2013 Oct 15; 521(15):3406-31.. View in PubMed
  • Common and distinct neural inputs to the medial central nucleus of the amygdala and anterior ventrolateral bed nucleus of stria terminalis in rats. Brain Struct Funct. 2013 Jan; 218(1):187-208.. View in PubMed