Michael Bienkowski, PhD

Assistant Professor of Physiology and Neuroscience and Biomedical Engineering

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Overview

Dr. Bienkowski is interested in characterizing brain cell types and understanding their susceptibility to neurodegenerative diseases like Alhzeimer’s disease and retinal degenerative diseases. His translational research laboratory (USC Center for Integrative Connectomics) uses state-of-the-art connectomics and transcriptomics approaches to investigate cell type-specific progressive changes to gene expression and connectivity in rodent and human brain tissue. A major goal of the lab is to build translational cell type atlases to guide clinical drug development and enhance the effectiveness of treatment plans at progressive disease stages.

Research Funding

  • Multiscale Modeling of Hippocampus Vulnerability to Alzheimer's Disease Neurodegeneration.
    NIH · R01AG092662 · Jan 1, 2026 – Dec 31, 2030 · Role: Principal Investigator
  • A Translational 3D Map of Hippocampal Cell Types To Drive Investigations of Alzheimer's Disease
    NIH · K01AG066847 · Aug 1, 2021 – Jul 31, 2026 · Role: Principal Investigator
  • Alzheimer's Disease Research Centers
    NIH · P30AG066530 · Sep 1, 2020 – Mar 31, 2030 · Role: Co-Principal Investigator
  • Structural and Functional Neural Network Mediating Fear Memory and PTSD
    NIH · F32MH107071 · Sep 16, 2015 – Sep 15, 2017 · Role: Principal Investigator

Publications

  • Immune challenge activates neural inputs to the ventrolateral bed nucleus of the stria terminalis. Physiol Behav. 2011 Aug 03; 104(2):257-65.. View in PubMed
  • Noradrenergic inputs to the paraventricular hypothalamus contribute to hypothalamic-pituitary-adrenal axis and central Fos activation in rats after acute systemic endotoxin exposure. Neuroscience. 2008 Oct 28; 156(4):1093-102.. View in PubMed