Ray Matthews, MD

Professor of Clinical Medicine

Director of Interventional Cardiology and Catheterization Laboratories

Director, CVI Outreach & Network Development

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Overview

Dr Matthews was recruited in 2007 to build and lead the section of interventional cardiology at USC. He has 35 years of experience in the catheter based treatment of a wide variety of cardiac disease states. He is well recognized as a pioneer in the performance of coronary interventions in patients too ill for bypass surgery, by using temporary ventricular assist devices during coronary stenting. Dr Mathews was one of the first cardiologists to close congenital heart defects percutaneously in Los Angeles and has since accumulated a large experience in ASD, VSD and PFO closure. Dr Matthews developed a structural heart program at USC over the past decade where he helped USC lead in the early development of TAVR procedures and now has performed well over 1000 of these procedures himself. Through his leadership, USC now has robust programs to percutaneously replace aortic, pulmonic and mitral valves as well.

Dr Matthews maintains a large practice of patients referred with cardiac abnormalities too challenging for community practitioners. He is also a dedicated teacher and scientist. He has trained over 80 interventional cardiologists who have gone on to successful practices all over the US and the world. He is a sought after speaker on the topic of structural heart disease and high risk coronary intervention. He is also involved in research projects to develop implantable sensors that are patient operated to detect heart failure at home and synthetically produced artificial TAVR valves. Dr Matthews continues to innovate and lead in interventional cardiology assisting in the development of numerous medical devices to facilitate the performance of cardiac procedures less invasively, safely and with excellent outcomes.

Awards

  • American Heart Association: Group Investigator Award, 1986
  • Harbor-UCLA Medical Center: Distinguished Teaching Award, 1987
  • American Heart Association: First Place, Clinical Division, Laverne Titus Young Investigator Competition, 1987
  • Division of Cardiovascular Medicine, Keck School of Medicine of USC: Golden Apple Award for Outstanding Teaching, 2013

Publications

  • Detecting elevated left ventricular end diastolic pressure from simultaneously measured femoral pressure waveform and electrocardiogram. Physiol Meas. 2024 08 14; 45(8).. View in PubMed
  • Changes in higher order cognitive function between four watch keeping schedules. Sleep Adv. 2024; 5(1):zpae044.. View in PubMed
  • Instantaneous detection of acute myocardial infarction and ischaemia from a single carotid pressure waveform in rats. Eur Heart J Open. 2023 Sep; 3(5):oead099.. View in PubMed
  • The addition of evolocumab to maximal tolerated statin therapy improves walking performance in patients with peripheral arterial disease and intermittent claudication (Evol-PAD study). Cardiovasc Revasc Med. 2023 10; 55:1-5.. View in PubMed
  • Cardiology Assessment of Patients Undergoing Evaluation for Orthotopic Liver Transplantation. J Soc Cardiovasc Angiogr Interv. 2023 Jan-Feb; 2(1):100528.. View in PubMed
  • Abnormal left atrial body stiffness is predicted by appendage size: impact of appendage occlusion on left atrial mechanics assessed by pressure-volume analysis. Am J Physiol Heart Circ Physiol. 2022 09 01; 323(3):H559-H568.. View in PubMed
  • Bimekizumab: a dual IL-17A and IL-17F inhibitor for the treatment of psoriasis and psoriatic arthritis. Expert Rev Clin Immunol. 2021 10; 17(10):1073-1081.. View in PubMed
  • Self-expanding intra-annular versus commercially available transcatheter heart valves in high and extreme risk patients with severe aortic stenosis (PORTICO IDE): a randomised, controlled, non-inferiority trial. Lancet. 2020 09 05; 396(10252):669-683.. View in PubMed
  • Factors Associated With the Use of Bare Metal Stents in Patients With ST Elevation Myocardial Infarction. Cardiovasc Revasc Med. 2020 12; 21(12):1489-1492.. View in PubMed
  • In-Hospital Outcomes of Rotational Atherectomy in High-Risk Patients With Severely Calcified Left Main Coronary Artery Disease: A Single-Center Experience. J Invasive Cardiol. 2019 04; 31(4):101-106.. View in PubMed