Overview

Dr. Sun Young Lee is a board-certified retina surgeon and clinician-scientist at the University of Southern California, where she serves as a tenured Associate Professor of Ophthalmology and Physiology & Neuroscience. She has extensive expertise in diagnosing and managing complex, vision-threatening retinal conditions. Dr. Lee specializes in age-related macular degeneration, inherited retinal diseases, diabetic retinopathy, retinal detachment, and surgical complications. She is nationally and internationally recognized for her surgical precision, clinical expertise, and seamless dedication to patient care.

Dr. Lee’s patient care is empowered by cutting-edge research funded by the National Eye Institute. Her laboratory investigates the role of extracellular vesicles (EVs) in the pathogenesis and treatment of retinal disease. She leads the development of EV-based intraocular therapies, a transformative approach to targeted drug delivery, gene therapy, and regenerative medicine for blinding retinal disorders such as age-related macular degeneration, inherited retinal diseases, diabetic retinopathy. Her research is deeply committed to restoring and preserving vision in patients with challenging conditions and limited treatment options.

For more information on Dr. Lee’s work, visit LeeRetinaLab.com

Awards

  • ARVO Foundation: Eye Research/Retina Research Foundation Travel Grant, 2009
  • Los Angeles Ophthalmology Society (LASO): Dr. Henry & Lilian Nesburn Award for Best Research by a Resident, 2016
  • Women in Retina (WinR) Mentoring Program: Travel Grant, 2016
  • Fellowship Research Award: The Retina Society, 2017
  • Presbyterian Health Foundation (PHF): Clinician Scientist Development Award, 2019
  • Women in Retin (WinR)/ American Society of Retina Specialist (ASRS): Mina Chung Research Award, 2021
  • Alcon Research Institute: Young Investigator Award, 2023
  • American Society of Retina Specialists: Fellow, 2024
  • Association for Research in Vision and Ophthalmology (ARVO): Silver Fellow, 2025

Education and Training

  • Pusan National University, S. Korea — MD — 1999
  • University of Ulsan, S. Korea — PhD — 2007
  • Asan Medical Center , S. Korea — Ophthalmology Residency/Vitreoretinal Surgery Fellowship — 2007
  • Johns Hopkins University, MD — Post-doctoral Fellowship — 2010
  • University of Southern California, CA — Ophthalmology Residency — 2016
  • University of Iowa , IA — Vitreoretinal Surgery Fellowship — 2018

Research Funding

  • Extracellular vesicle-based intraocular therapy combined with active targeting of ocular neovascularization
    NIH/NEI · R01EY034193 · Feb 1, 2024 – Jan 31, 2029 · Role: Principal Investigator
  • Extracellular Vesicle Therapy for Diabetic Retinopathy
    NIH/NEI · R21EY035425 · Sep 30, 2023 – Aug 31, 2025 · Role: Principal Investigator
  • USC Alpha Clinic Network Expansion for Cell and Gene Therapies (PI: Buchanan, T)
    California Institute for Regenerative Medicine (CIRM) · Feb 1, 2023 – Jan 31, 2027 · Role: Vision Disorder Lead
  • Exosome based intraocular therapy combined with active targeting of ocular neovascularization
    NIH/NEI · R56EY034193 · Sep 30, 2022 – Sep 29, 2024 · Role: Principal Investigator
  • USC Roski Eye K12 Clinician-Vision Scientist Training Program
    NIH/NEI · K12EY028873 · Feb 1, 2022 – Jan 31, 2024 · Role: Scholar

Publications

  • Development of Potency Assays for Therapeutic EVs: The Art of Congruence. J Extracell Vesicles. 2026 Jun; 15(6):e70336.. View in PubMed
  • Ocular manifestations of STAT3 gain-of-function syndrome: A case of papillitis, retinitis, and retinal vasculitis. Am J Ophthalmol Case Rep. 2026 Jun; 42:102540.. View in PubMed
  • Hemorrhagic capsular block syndrome after cataract surgery. J Cataract Refract Surg. 2025 Dec 01; 51(12):1151-1152.. View in PubMed
  • Small Extracellular Vesicle-Mediated Peptide Delivery to the Mouse Corneal Endothelium In Vivo. Ophthalmol Sci. 2026 Jan; 6(1):100900.. View in PubMed
  • Large Macular Hemorrhage in Cytomegalovirus Retinitis. Ophthalmol Retina. 2025 Nov; 9(11):e103.. View in PubMed
  • A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research. J Extracell Vesicles. 2024 12; 13(12):e70023.. View in PubMed
  • Dynamics of microRNA secreted via extracellular vesicles during the maturation of embryonic stem cell-derived retinal pigment epithelium. J Extracell Biol. 2024 Sep; 3(9):e70001.. View in PubMed
  • An Eye on Extracellular Vesicles: Trends and Clinical Translations in Vision Research. Ophthalmol Sci. 2025 Jan-Feb; 5(1):100619.. View in PubMed
  • Preretinal Deposits in a Keratoprosthesis-Associated Bacterial Endophthalmitis. Ophthalmol Retina. 2024 Nov; 8(11):e42.. View in PubMed
  • Unveiling Drivers of Retinal Degeneration in RCS Rats: Functional, Morphological, and Molecular Insights. Int J Mol Sci. 2024 Mar 28; 25(7).. View in PubMed