Overview

Dr. Sun Young Lee is a board-certified retina surgeon and clinician-scientist at the University of Southern California, where she serves as a tenured Associate Professor of Ophthalmology and Physiology & Neuroscience. She has extensive expertise in diagnosing and managing complex, vision-threatening retinal conditions. Dr. Lee specializes in age-related macular degeneration, inherited retinal diseases, diabetic retinopathy, retinal detachment, and surgical complications. She is nationally and internationally recognized for her surgical precision, clinical expertise, and seamless dedication to patient care.

Dr. Lee’s patient care is empowered by cutting-edge research funded by the National Eye Institute. Her laboratory investigates the role of extracellular vesicles (EVs) in the pathogenesis and treatment of retinal disease. She leads the development of EV-based intraocular therapies, a transformative approach to targeted drug delivery, gene therapy, and regenerative medicine for blinding retinal disorders such as age-related macular degeneration, inherited retinal diseases, diabetic retinopathy. Her research is deeply committed to restoring and preserving vision in patients with challenging conditions and limited treatment options.

For more information on Dr. Lee’s work, visit LeeRetinaLab.com

Awards

  • ARVO Foundation: Eye Research/Retina Research Foundation Travel Grant, 2009
  • Los Angeles Ophthalmology Society (LASO): Dr. Henry & Lilian Nesburn Award for Best Research by a Resident, 2016
  • Women in Retina (WinR) Mentoring Program: Travel Grant, 2016
  • Fellowship Research Award: The Retina Society, 2017
  • Presbyterian Health Foundation (PHF): Clinician Scientist Development Award, 2019
  • Women in Retin (WinR)/ American Society of Retina Specialist (ASRS): Mina Chung Research Award, 2021
  • Alcon Research Institute: Young Investigator Award, 2023
  • American Society of Retina Specialists: Fellow, 2024
  • Association for Research in Vision and Ophthalmology (ARVO): Silver Fellow, 2025

Education and Training

  • Pusan National University, S. Korea — MD — 1999
  • University of Ulsan, S. Korea — PhD — 2007
  • Asan Medical Center , S. Korea — Ophthalmology Residency/Vitreoretinal Surgery Fellowship — 2007
  • Johns Hopkins University, MD — Post-doctoral Fellowship — 2010
  • University of Southern California, CA — Ophthalmology Residency — 2016
  • University of Iowa , IA — Vitreoretinal Surgery Fellowship — 2018

Research Funding

  • Extracellular vesicle-based intraocular therapy combined with active targeting of ocular neovascularization
    NIH/NEI · R01EY034193 · Feb 1, 2024 – Jan 31, 2029 · Role: Principal Investigator
  • Extracellular Vesicle Therapy for Diabetic Retinopathy
    NIH/NEI · R21EY035425 · Sep 30, 2023 – Aug 31, 2025 · Role: Principal Investigator
  • USC Alpha Clinic Network Expansion for Cell and Gene Therapies (PI: Buchanan, T)
    California Institute for Regenerative Medicine (CIRM) · Feb 1, 2023 – Jan 31, 2027 · Role: Vision Disorder Lead
  • Exosome based intraocular therapy combined with active targeting of ocular neovascularization
    NIH/NEI · R56EY034193 · Sep 30, 2022 – Sep 29, 2024 · Role: Principal Investigator
  • USC Roski Eye K12 Clinician-Vision Scientist Training Program
    NIH/NEI · K12EY028873 · Feb 1, 2022 – Jan 31, 2024 · Role: Scholar

Publications

  • N-Acetylcysteine promotes long-term survival of cones in a model of retinitis pigmentosa. J Cell Physiol. 2011 Jul; 226(7):1843-9.. View in PubMed
  • Constituents of bile, bilirubin and TUDCA, protect against oxidative stress-induced retinal degeneration. J Neurochem. 2011 Jan; 116(1):144-53.. View in PubMed
  • Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion. Ophthalmology. 2010 Jun; 117(6):1134-1146.e3.. View in PubMed
  • Intravitreal bevacizumab alone versus in combination with photodynamic therapy for the treatment of neovascular maculopathy in patients aged 50 years or older: 1-year results of a prospective clinical study. Acta Ophthalmol. 2012 Feb; 90(1):61-7.. View in PubMed
  • Rapid progression of subclinical age-related macular degeneration in the untreated fellow eye after intravitreal bevacizumab. Acta Ophthalmol. 2009 Sep; 87(6):685-7.. View in PubMed
  • Ocular sarcoidosis in a Korean population. J Korean Med Sci. 2009 Jun; 24(3):413-9.. View in PubMed
  • NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa. J Neurochem. 2009 Aug; 110(3):1028-37.. View in PubMed
  • Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa. Mol Ther. 2009 May; 17(5):778-86.. View in PubMed
  • Bilateral toxoplasma retinochoroiditis simulating cytomegalovirus retinitis in an allogeneic bone marrow transplant patient. Korean J Ophthalmol. 2008 Sep; 22(3):197-200.. View in PubMed
  • Inhibitory effect of bevacizumab on the angiogenesis and growth of retinoblastoma. Arch Ophthalmol. 2008 Jul; 126(7):953-8.. View in PubMed