Yang Chai, DMD, PhD, DDS

Dean

G. Donald and Marian James Montgomery Professor of Dentistry

University Professor of Dentistry, Stem Cell Biology and Regenerative Medicine, and Otolaryngology-Head & Neck Surgery

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Overview

Yang Chai, DMD, PhD, DDS is the chair of the National Institute of Dental and Craniofacial Research Board of Scientific Counselors.

Professor Chai, who holds the George and Mary Lou Boone Chair in Craniofacial Biology and is the associate dean of research and director of the Center for Craniofacial Molecular Biology at the Ostrow School, has been a member of the board since 2008 and will serve a one-year term as chair. A total of nine board members, including the chair, are selected from among the most accomplished and celebrated experts in biomedical, dental and craniofacial science.

Chai is internationally renowned for his research into the genetics, cellular signaling, and development of cranial and facial structures, including the causes of and potential preventive measures for facial deformities such as cleft palate. Among his many honors, he has received a National Institutes of Health MERIT Award, has been elected as an American Association for the Advancement of Sciences Fellow, has received an International Association for Dental Research Distinguished Scientist Award, and has served on the editorial boards of several scientific journals. He is also an alumnus of the Ostrow School of Dentistry and is an award-winning educator and a practicing dentist at the school.

Awards

  • NIDCR, NIH: Chair of the Board of Scientific Counselors, 2013
  • Craniofacial Biology Research Award: IADR Distinguished Scientist Award, 2011
  • Journal of Bone and Mineral Research: Editorial Board, 2010
     – 2014
  • NIH: NIH MERIT Award, 2010
  • American Association for the Advancement of Sciences (AAAS) Elected Fellow, 2010
  • NIDCR, NIH: Member of the Board of Scientific Counselors, 2008
     – 2012
  • JBMR: Editorial Board DEVELOPMENTAL BIOLOGY, 2007
     – 2014
  • The Chinese Journal of Dental Research: Editorial Board, 2006
     – 2014
  • Regular member of SBDD study section CSR NIH, 2004
     – 2008
  • Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration, 2004
  • Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration, 2006
  • NIH Ad hoc grant reviewer (OBM-2, ODCS) and Reviewer for the Welcome Trust, UK, 2002
     – 2014
  • University of Southern California: Award of Excellence in Teaching, 2001
     – 2003
  • University of Southern California: James H. Zumberge Faculty Research and Innovation Award, 1997
  • University of Southern California: James H. Zumberge Faculty Research and Innovation Award, 2007
  • University of Southern California: Annual Excellence in Teaching Award, 1997
  • OKU Scholarship award for outstanding academic performance, 1996
  • Special Recognition by the Dean for outstanding service and contribution to the University of Southe, 1996
  • University of Southern California, School of Dentistry: Annual Teaching Award, 1995
  • University of Southern California, (GPA 4.0): PHI KAPPA PHI, All-University Honor Society, 1991
  • University of Southern California: Certificate for Outstanding Academic Achievement, 1990

Research Funding

  • The Regulatory Mechanism of Craniofacial Morphogenesis and Malformations
    NIH · R01DE035453 · Aug 18, 2026 – Jun 30, 2029 · Role: Principal Investigator
  • USC Facebase IV Craniofacial Development and Dysmorpholoy Data Management and Integration Hub (FaceBase IV))
    NIH · U24DE034163 · Aug 15, 2024 – May 31, 2029 · Role: Co-Principal Investigator
  • Center for TMD IMPACT
    NIH · R34DE033572 · Sep 19, 2023 – Sep 18, 2024 · Role: Principal Investigator
  • Mechanisms and rescue of craniosynostosis associated with gene-environment interaction
    NIH · R01DE030901 · Jul 1, 2021 – Apr 30, 2026 · Role: Co-Principal Investigator
  • Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)
    NIH · U24DE029463 · May 7, 2020 – Apr 30, 2025 · Role: Principal Investigator
  • USC FaceBase III Craniofacial Development and Dysmorpholoy Data Management and Integration Hub
    NIH · U01DE028729 · Aug 1, 2019 – Jul 31, 2024 · Role: Co-Principal Investigator
  • Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)
    NIH · U24DE026914 · Mar 1, 2017 – Feb 28, 2021 · Role: Co-Principal Investigator
  • Molecular and Cellular Basis of Craniosynostosis
    NIH · R01DE026339 · Jul 1, 2016 – Jul 31, 2026 · Role: Co-Principal Investigator
  • MOLECULAR REGULATORY MECHANISM OF MESENCHYMAL STEM CELLS IN ADULT MOUSE INCISOR
    NIH · R01DE025221 · May 1, 2016 – Dec 31, 2027 · Role: Principal Investigator
  • CENTER FOR DENTAL, ORAL AND CRANIOFACIAL TISSUE ORGAN REGENERATION (C-DOCTOR)
    NIH · R34DE025575 · Sep 1, 2015 – Aug 31, 2017 · Role: Principal Investigator
  • INTEGRATED RESEARCH OF FUNCTIONAL GENOMICS AND CRANIOFACIAL MORPHOGENESIS
    NIH · U01DE024421 · May 12, 2014 – Apr 30, 2020 · Role: Principal Investigator
  • The Molecular Regulatory Mechanism of Tooth Root Development
    NIH · R01DE022503 · Jul 19, 2012 – Apr 30, 2029 · Role: Principal Investigator
  • RESEARCH ON FUNCTIONAL GENOMICS, IMAGE ANALYSIS AND RESCUE OF CLEFT PALATE
    NIH · U01DE020065 · Sep 21, 2009 – Apr 30, 2015 · Role: Principal Investigator
  • Interdisciplinary New Faculty Recruitment in Craniofacial Development
    NIH · P30DE020750 · Sep 17, 2009 – Aug 31, 2013 · Role: Principal Investigator
  • Molecular Regulatory Mechanism of Calvarial Morphogenesis
    NIH · R01DE017007 · Sep 1, 2005 – Aug 31, 2012 · Role: Principal Investigator
  • CRANIOFACIAL MORHOGENESIS AND TISSUE REGENERATION GORDON CONFERENCE
    NIH · R13DE015783 · Jan 1, 2004 – Dec 31, 2008 · Role: Co-Principal Investigator
  • MOLECULAR REGULATORY MECHANISM OF TONGUE MORPHOGENESIS
    NIH · R01DE014078 · Apr 1, 2001 – Jun 30, 2015 · Role: Principal Investigator
  • TGF BETA SIGNALING AND CRANIOFACIAL MORPHOGENESIS
    NIH · R01DE012711 · Jan 1, 1999 – Jul 31, 2024 · Role: Principal Investigator
  • TGF BETA SIGNALING AND CRANIOFACIAL MORPHOGENESIS
    NIH · R37DE012711 · Jan 1, 1999 – Jul 31, 2019 · Role: Principal Investigator

Publications

  • Neural crest and periderm-specific requirements of Irf6 during neural tube and craniofacial development. Dev Biol. 2025 06; 522:106-115.. View in PubMed
  • Unveiling the placental bacterial microbiota: implications for maternal and infant health. Front Physiol. 2025; 16:1544216.. View in PubMed
  • Capturing Copper Single Atom in Proton Donor Stimulated O-End Nitrate Reduction. Adv Mater. 2025 Mar; 37(12):e2415632.. View in PubMed
  • Van Der Waals Hybrid Integration of 2D Semimetals for Broadband Photodetection. Adv Mater. 2025 Dec; 37(48):e2415717.. View in PubMed
  • 2D (NH4)BiI3 enables non-volatile optoelectronic memories for machine learning. Nat Commun. 2025 Feb 13; 16(1):1609.. View in PubMed
  • Engineering DNA Nanodevices with Multi-site Recognition and Multi-signal Output for Accurate Intracellular LncRNA Imaging. Anal Chem. 2025 02 18; 97(6):3378-3386.. View in PubMed
  • High-Rate Lithium-Ion Capacitor Diode Towards Multifrequency Ion/Electron-Coupling Logic Operations. Angew Chem Int Ed Engl. 2025 Feb 17; 64(8):e202420404.. View in PubMed
  • Capacitorless Dynamic Random Access Memory with 2D Transistors by One-Step Transfer of van der Waals Dielectrics and Electrodes. ACS Nano. 2025 Jan 21; 19(2):2848-2856.. View in PubMed
  • Supramolecular DNA Nanodevice Assembled via RCA and HCR Cascade Reaction on Tetrahedral DNA Nanostructure for Sensitive Detection and Intracellular Imaging of Dual-miRNAs Associated with Liver Cancer. Anal Chem. 2025 01 14; 97(1):686-693.. View in PubMed
  • Advanced Ligase Chain Reaction Strategy to Generate a Circular DNA Walker for Electrochemiluminescent Detection of Single Nucleotide Polymorphism. Anal Chem. 2024 12 31; 96(52):20587-20593.. View in PubMed