Yang Chai, DMD, PhD, DDS

Dean

G. Donald and Marian James Montgomery Professor of Dentistry

University Professor of Dentistry, Stem Cell Biology and Regenerative Medicine, and Otolaryngology-Head & Neck Surgery

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Overview

Yang Chai, DMD, PhD, DDS is the chair of the National Institute of Dental and Craniofacial Research Board of Scientific Counselors.

Professor Chai, who holds the George and Mary Lou Boone Chair in Craniofacial Biology and is the associate dean of research and director of the Center for Craniofacial Molecular Biology at the Ostrow School, has been a member of the board since 2008 and will serve a one-year term as chair. A total of nine board members, including the chair, are selected from among the most accomplished and celebrated experts in biomedical, dental and craniofacial science.

Chai is internationally renowned for his research into the genetics, cellular signaling, and development of cranial and facial structures, including the causes of and potential preventive measures for facial deformities such as cleft palate. Among his many honors, he has received a National Institutes of Health MERIT Award, has been elected as an American Association for the Advancement of Sciences Fellow, has received an International Association for Dental Research Distinguished Scientist Award, and has served on the editorial boards of several scientific journals. He is also an alumnus of the Ostrow School of Dentistry and is an award-winning educator and a practicing dentist at the school.

Awards

  • NIDCR, NIH: Chair of the Board of Scientific Counselors, 2013
  • Craniofacial Biology Research Award: IADR Distinguished Scientist Award, 2011
  • Journal of Bone and Mineral Research: Editorial Board, 2010
     – 2014
  • NIH: NIH MERIT Award, 2010
  • American Association for the Advancement of Sciences (AAAS) Elected Fellow, 2010
  • NIDCR, NIH: Member of the Board of Scientific Counselors, 2008
     – 2012
  • JBMR: Editorial Board DEVELOPMENTAL BIOLOGY, 2007
     – 2014
  • The Chinese Journal of Dental Research: Editorial Board, 2006
     – 2014
  • Regular member of SBDD study section CSR NIH, 2004
     – 2008
  • Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration, 2004
  • Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration, 2006
  • NIH Ad hoc grant reviewer (OBM-2, ODCS) and Reviewer for the Welcome Trust, UK, 2002
     – 2014
  • University of Southern California: Award of Excellence in Teaching, 2001
     – 2003
  • University of Southern California: James H. Zumberge Faculty Research and Innovation Award, 1997
  • University of Southern California: James H. Zumberge Faculty Research and Innovation Award, 2007
  • University of Southern California: Annual Excellence in Teaching Award, 1997
  • OKU Scholarship award for outstanding academic performance, 1996
  • Special Recognition by the Dean for outstanding service and contribution to the University of Southe, 1996
  • University of Southern California, School of Dentistry: Annual Teaching Award, 1995
  • University of Southern California, (GPA 4.0): PHI KAPPA PHI, All-University Honor Society, 1991
  • University of Southern California: Certificate for Outstanding Academic Achievement, 1990

Research Funding

  • The Regulatory Mechanism of Craniofacial Morphogenesis and Malformations
    NIH · R01DE035453 · Aug 18, 2026 – Jun 30, 2029 · Role: Principal Investigator
  • USC Facebase IV Craniofacial Development and Dysmorpholoy Data Management and Integration Hub (FaceBase IV))
    NIH · U24DE034163 · Aug 15, 2024 – May 31, 2029 · Role: Co-Principal Investigator
  • Center for TMD IMPACT
    NIH · R34DE033572 · Sep 19, 2023 – Sep 18, 2024 · Role: Principal Investigator
  • Mechanisms and rescue of craniosynostosis associated with gene-environment interaction
    NIH · R01DE030901 · Jul 1, 2021 – Apr 30, 2026 · Role: Co-Principal Investigator
  • Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)
    NIH · U24DE029463 · May 7, 2020 – Apr 30, 2025 · Role: Principal Investigator
  • USC FaceBase III Craniofacial Development and Dysmorpholoy Data Management and Integration Hub
    NIH · U01DE028729 · Aug 1, 2019 – Jul 31, 2024 · Role: Co-Principal Investigator
  • Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)
    NIH · U24DE026914 · Mar 1, 2017 – Feb 28, 2021 · Role: Co-Principal Investigator
  • Molecular and Cellular Basis of Craniosynostosis
    NIH · R01DE026339 · Jul 1, 2016 – Jul 31, 2026 · Role: Co-Principal Investigator
  • MOLECULAR REGULATORY MECHANISM OF MESENCHYMAL STEM CELLS IN ADULT MOUSE INCISOR
    NIH · R01DE025221 · May 1, 2016 – Dec 31, 2027 · Role: Principal Investigator
  • CENTER FOR DENTAL, ORAL AND CRANIOFACIAL TISSUE ORGAN REGENERATION (C-DOCTOR)
    NIH · R34DE025575 · Sep 1, 2015 – Aug 31, 2017 · Role: Principal Investigator
  • INTEGRATED RESEARCH OF FUNCTIONAL GENOMICS AND CRANIOFACIAL MORPHOGENESIS
    NIH · U01DE024421 · May 12, 2014 – Apr 30, 2020 · Role: Principal Investigator
  • The Molecular Regulatory Mechanism of Tooth Root Development
    NIH · R01DE022503 · Jul 19, 2012 – Apr 30, 2029 · Role: Principal Investigator
  • RESEARCH ON FUNCTIONAL GENOMICS, IMAGE ANALYSIS AND RESCUE OF CLEFT PALATE
    NIH · U01DE020065 · Sep 21, 2009 – Apr 30, 2015 · Role: Principal Investigator
  • Interdisciplinary New Faculty Recruitment in Craniofacial Development
    NIH · P30DE020750 · Sep 17, 2009 – Aug 31, 2013 · Role: Principal Investigator
  • Molecular Regulatory Mechanism of Calvarial Morphogenesis
    NIH · R01DE017007 · Sep 1, 2005 – Aug 31, 2012 · Role: Principal Investigator
  • CRANIOFACIAL MORHOGENESIS AND TISSUE REGENERATION GORDON CONFERENCE
    NIH · R13DE015783 · Jan 1, 2004 – Dec 31, 2008 · Role: Co-Principal Investigator
  • MOLECULAR REGULATORY MECHANISM OF TONGUE MORPHOGENESIS
    NIH · R01DE014078 · Apr 1, 2001 – Jun 30, 2015 · Role: Principal Investigator
  • TGF BETA SIGNALING AND CRANIOFACIAL MORPHOGENESIS
    NIH · R01DE012711 · Jan 1, 1999 – Jul 31, 2024 · Role: Principal Investigator
  • TGF BETA SIGNALING AND CRANIOFACIAL MORPHOGENESIS
    NIH · R37DE012711 · Jan 1, 1999 – Jul 31, 2019 · Role: Principal Investigator

Publications

  • Loss of Runx2 in Gli1+ osteogenic progenitors prevents bone loss following ovariectomy. JBMR Plus. 2025 Jan; 9(1):ziae141.. View in PubMed
  • The G protein-coupled receptor ADGRG6 maintains mouse growth plate homeostasis through IHH signaling. J Bone Miner Res. 2024 10 29; 39(11):1644-1658.. View in PubMed
  • Two-Dimensional MoS2-Based Anisotropic Synaptic Transistor for Neuromorphic Computing by Localized Electron Beam Irradiation. Adv Sci (Weinh). 2024 Dec; 11(45):e2408210.. View in PubMed
  • Sequentially Activated-Dumbbell DNA Nanodevices for Accurate Detection of Uracil-DNA Glycosylase via PER-Based Orthogonal Signal Outputs. Anal Chem. 2024 10 22; 96(42):17013-17020.. View in PubMed
  • Object Motion Detection Enabled by Reconfigurable Neuromorphic Vision Sensor under Ferroelectric Modulation. ACS Nano. 2024 Oct 08; 18(40):27727-27737.. View in PubMed
  • Electronics and Optoelectronics Based on Tellurium. Adv Mater. 2024 Nov; 36(45):e2408969.. View in PubMed
  • Ingenious dual-circle DNA walker-mediated electrochemical biosensor for rapid and ultrasensitive detection of microRNA. Biosens Bioelectron. 2025 Jan 01; 267:116719.. View in PubMed
  • Confinement-enhanced electrochemiluminescence of copper nanoclusters on 3D layered double hydroxide for ultrasensitive detection of GFAP. Biosens Bioelectron. 2024 Dec 01; 265:116685.. View in PubMed
  • Electronically Reconfigurable Memristive Neuron Capable of Operating in Both Excitation and Inhibition Modes. Nano Lett. 2024 09 04; 24(35):10865-10873.. View in PubMed
  • Optoelectronic Devices for In-Sensor Computing. Adv Mater. 2025 Jun; 37(23):e2407476.. View in PubMed