Press Release

Urologists to perform world’s first bladder transplant

Surgeons with Keck Medicine of USC launch clinical trial to enroll first-ever bladder transplant patient after multiple successful research procedures

April 30, 2023
The Keck Medicine of USC surgical team evaluates the integrity of a bladder during the research and development stage of bladder transplantation. (Photo courtesy of USC Urology)
The Keck Medicine of USC surgical team evaluates the integrity of a bladder during the research and development stage of bladder transplantation. (Photo courtesy of USC Urology)

Keck Medicine of USC

No one has ever performed a bladder transplant in humans. But that may be about to change.

Urologists with Keck Medicine of USC have launched a clinical trial to perform the world’s first human bladder transplant.

The trial is actively screening potential participants for this first-ever type of transplantation.

During the procedure, the patient’s diseased bladder will be removed and replaced with a healthy bladder from a deceased donor.

“Transplantation is a lifesaving treatment option for conditions affecting many major organs, and transplanting a bladder could be a historic step in improving lives,” said Inderbir Gill, MD, founding executive director for USC Urology, part of Keck Medicine. Gill is also the principal investigator of the clinical trial and leading the transplantation efforts. “We could be on the verge of a medical advance that has the potential to revolutionize how we treat terminally compromised bladders.”

Hundreds of millions of people around the globe experience varying degrees of bladder disease and dysfunction. Some patients with these conditions may require a bladder reconstruction, a surgical procedure wherein the bladder is removed, and a new bladder is made from the patient’s own intestines. However, the procedure carries a high risk of early and delayed adverse side effects, and not every patient is a candidate for this surgery. (…Read More)