Faculty

Daniel Oscar Stram, PhD
Daniel Oscar Stram, PhD
Professor of Preventive Medicine
Preventive Medicine
SSB 202D 2001 N. Soto Street Health Sciences Campus Los Angeles
My research is on general biostatistical issues in epidemiology, and I am a long time collaborator on a number of important prospective (cohort) studies of cancer and other diseases. These include the Atomic Bomb Survivors Study, the Multiethnic Cohort Study, and the Children's Health Study. I participate in many other projects in the Preventive Medicine Department at USC. I have particular interest in measurement error issues in dosimetry for radiation epidemiology and in dietary assessment for nutritional epidemiology. I have recently begun working on association-based testing for the influence upon cancer risk of genomic variation in candidate genes using nested case-control studies within the MEC, with special emphasis on haplotype-based risk estimation and haplotype-tagging SNP selection. See the publications and software development list below, for further information.

Association of a Pathway-Specific Genetic Risk Score With Risk of Radiation-Associated Contralateral Breast Cancer JAMA Netw Open. 2019 Sep 04; 2(9):e1912259. . View in PubMed

Association between ambient air pollution and breast cancer risk: The multiethnic cohort study Int J Cancer. 2019 Mar 28. . View in PubMed

Association between mitochondrial genetic variation and breast cancer risk: The Multiethnic Cohort PLoS One. 2019; 14(10):e0222284. . View in PubMed

Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women: An Update From the Women's Environmental Cancer and Radiation Epidemiology Study J Clin Oncol. 2018 05 20; 36(15):1513-1520. . View in PubMed

Association of internal smoking dose with blood DNA methylation in three racial/ethnic populations Clin Epigenetics. 2018 08 23; 10(1):110. . View in PubMed

Coffee Drinking and Alcoholic and Nonalcoholic Fatty Liver Diseases and Viral Hepatitis in the Multiethnic Cohort Clin Gastroenterol Hepatol. 2017 08; 15(8):1305-1307. . View in PubMed

Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry Cancer Epidemiol Biomarkers Prev. 2017 07; 26(7):1016-1026. . View in PubMed

Association of Common Genetic Variants With Contralateral Breast Cancer Risk in the WECARE Study J Natl Cancer Inst. 2017 10 01; 109(10). . View in PubMed

Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study PLoS One. 2017; 12(5):e0178435. . View in PubMed

BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer Cancer Res. 2017 06 01; 77(11):2789-2799. . View in PubMed

Association analysis identifies 65 new breast cancer risk loci Nature. 2017 11 02; 551(7678):92-94. . View in PubMed

A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer Int J Cancer. 2016 Dec 15; 139(12):2646-2654. . View in PubMed

Breast Cancer Risk From Modifiable and Nonmodifiable Risk Factors Among White Women in the United States JAMA Oncol. 2016 Oct 01; 2(10):1295-1302. . View in PubMed

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation Nat Commun. 2016 Apr 07; 7:10979. . View in PubMed

A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci Cancer Epidemiol Biomarkers Prev. 2016 12; 25(12):1609-1618. . View in PubMed

Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk Obstet Gynecol. 2016 05; 127(5):828-36. . View in PubMed

Benzene Uptake and Glutathione S-transferase T1 Status as Determinants of S-Phenylmercapturic Acid in Cigarette Smokers in the Multiethnic Cohort PLoS One. 2016; 11(3):e0150641. . View in PubMed

Associations Between Genetic Ancestries and Nicotine Metabolism Biomarkers in the Multiethnic Cohort Study Am J Epidemiol. 2015 Dec 01; 182(11):945-51. . View in PubMed

ABO blood group alleles and prostate cancer risk: Results from the breast and prostate cancer cohort consortium (BPC3) Prostate. 2015 Nov; 75(15):1677-81. . View in PubMed

Atopic allergic conditions and colorectal cancer risk in the Multiethnic Cohort Study Am J Epidemiol. 2015 Jun 01; 181(11):889-97. . View in PubMed

Association of Genes, Pathways, and Haplogroups of the Mitochondrial Genome with the Risk of Colorectal Cancer: The Multiethnic Cohort PLoS One. 2015; 10(9):e0136796. . View in PubMed

Additive interactions between susceptibility single-nucleotide polymorphisms identified in genome-wide association studies and breast cancer risk factors in the Breast and Prostate Cancer Cohort Consortium Am J Epidemiol. 2014 Nov 15; 180(10):1018-27. . View in PubMed

Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium Hum Mol Genet. 2014 Nov 15; 23(22):6096-111. . View in PubMed

A comprehensive examination of breast cancer risk loci in African American women Hum Mol Genet. 2014 Oct 15; 23(20):5518-26. . View in PubMed

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer Nat Genet. 2014 Oct; 46(10):1103-9. . View in PubMed

Analysis of cancer risks in populations near nuclear facilities: Phase IA report by the National Academies Nuclear and Radiation Studies Board. Health Phys. 2014 Feb; 106(2):305-6. . View in PubMed

Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls Hum Mol Genet. 2013 Jun 15; 22(12):2539-50. . View in PubMed

Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):880-90. . View in PubMed

A genome-wide scan for breast cancer risk haplotypes among African American women PLoS One. 2013; 8(2):e57298. . View in PubMed

A genome-wide association study of breast cancer in women of African ancestry Hum Genet. 2013 Jan; 132(1):39-48. . View in PubMed

A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11 Hum Mol Genet. 2012 Dec 15; 21(24):5373-84. . View in PubMed

Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium Am J Epidemiol. 2012 Dec 15; 176(12):1121-9. . View in PubMed

Common genetic variants in prostate cancer risk prediction--results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3) Cancer Epidemiol Biomarkers Prev. 2012 Mar; 21(3):437-44. . View in PubMed

A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer Nat Genet. 2011 Oct 30; 43(12):1210-4. . View in PubMed

Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans PLoS Genet. 2011 May; 7(5):e1001387. . View in PubMed

Age-specific effects of hormone therapy use on overall mortality and ischemic heart disease mortality among women in the California Teachers Study Menopause. 2011 Mar; 18(3):253-61. . View in PubMed

Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3 PLoS One. 2011 Feb 24; 6(2):e17142. . View in PubMed

Caution in generalizing known genetic risk markers for breast cancer across all ethnic/racial populations Eur J Hum Genet. 2011 Feb; 19(2):243-5. . View in PubMed

Common variants at 19p13 are associated with susceptibility to ovarian cancer Nat Genet. 2010 Oct; 42(10):880-4. . View in PubMed

A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations Cancer Epidemiol Biomarkers Prev. 2010 Oct; 19(10):2639-46. . View in PubMed

Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium Hum Mol Genet. 2010 Oct 01; 19(19):3873-84. . View in PubMed

A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24 Nat Genet. 2010 Oct; 42(10):874-9. . View in PubMed

A large study of androgen receptor germline variants and their relation to sex hormone levels and prostate cancer riskResults from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. J Clin Endocrinol Metab. 2010 Sep; 95(9):E121-7. . View in PubMed

Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups PLoS Genet. 2010 Aug 26; 6(8). . View in PubMed

A comprehensive analysis of common IGF1, IGFBP1 and IGFBP3 genetic variation with prospective IGF-I and IGFBP-3 blood levels and prostate cancer risk among Caucasians Hum Mol Genet. 2010 Aug 01; 19(15):3089-101. . View in PubMed

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p222. Nat Genet. 2009 Sep; 41(9):996-1000. . View in PubMed

Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study Hum Mol Genet. 2009 Jun 15; 18(12):2297-304. . View in PubMed

A kinship-based modification of the armitage trend test to address hidden population structure and small differential genotyping errors PLoS One. 2009 Jun 08; 4(6):e5825. . View in PubMed

Association of diabetes with prostate cancer risk in the multiethnic cohort Am J Epidemiol. 2009 Apr 15; 169(8):937-45. . View in PubMed

Comprehensive association testing of common genetic variation in DNA repair pathway genes in relationship with breast cancer risk in multiple populations Hum Mol Genet. 2008 Mar 15; 17(6):825-34. . View in PubMed

Comprehensive evaluation of ESR2 variation and ovarian cancer risk Cancer Epidemiol Biomarkers Prev. 2008 Feb; 17(2):393-6. . View in PubMed

Calcium, vitamin D, and dairy product intake and prostate cancer risk: the Multiethnic Cohort Study Am J Epidemiol. 2007 Dec 01; 166(11):1259-69. . View in PubMed

A Monte Carlo maximum likelihood method for estimating uncertainty arising from shared errors in exposures in epidemiological studies of nuclear workers Radiat Res. 2007 Dec; 168(6):757-63. . View in PubMed

A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the multiethnic cohort BMC Med Genet. 2007 Dec 01; 8:72. . View in PubMed

A common genetic risk factor for colorectal and prostate cancer Nat Genet. 2007 Aug; 39(8):954-6. . View in PubMed

A common 8q24 variant in prostate and breast cancer from a large nested case-control study Cancer Res. 2007 Apr 01; 67(7):2951-6. . View in PubMed

Beta-cryptoxanthin and lung cancer in Shanghai, China--an examination of potential confounding with cigarette smoking using urinary cotinine as a biomarker for true tobacco exposure Nutr Cancer. 2007; 57(2):123-9. . View in PubMed

A systematic assessment of common genetic variation in CYP11A and risk of breast cancer Cancer Res. 2006 Dec 15; 66(24):12019-25. . View in PubMed

An utter refutation of the "Fundamental Theorem of the HapMap" by Terwilliger and Hiekkalinna Eur J Hum Genet. 2006 Dec; 14(12):1238-9. . View in PubMed

Asparagine depletion after pegylated Ecoli asparaginase treatment and induction outcome in children with acute lymphoblastic leukemia in first bone marrow relapse: a Children's Oncology Group study (CCG-1941). Pediatr Blood Cancer. 2006 Aug; 47(2):141-6. . View in PubMed

Bone marrow transplantation versus prolonged intensive chemotherapy for children with acute lymphoblastic leukemia and an initial bone marrow relapse within 12 months of the completion of primary therapy: Children's Oncology Group study CCG-1941 J Clin Oncol. 2006 Jul 01; 24(19):3150-6. . View in PubMed

Common genetic variation at PTEN and risk of sporadic breast and prostate cancer Cancer Epidemiol Biomarkers Prev. 2006 May; 15(5):1021-5. . View in PubMed

Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic Cohort J Natl Cancer Inst. 2006 Jan 18; 98(2):123-34. . View in PubMed

A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3) Breast Cancer Res. 2006; 8(5):R54. . View in PubMed

Asymptotic equivalence between two score tests for haplotype-specific risk in general linear models Genet Epidemiol. 2005 Sep; 29(2):166-70. . View in PubMed

A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk Cancer Res. 2005 Aug 15; 65(16):7516-22. . View in PubMed

Comparison of prostate-specific antigen and hormone levels among men in Singapore and the United States Cancer Epidemiol Biomarkers Prev. 2005 Jul; 14(7):1692-6. . View in PubMed

BRCA1 variants in a family study of African-American and Latina women Hum Genet. 2005 May; 116(6):497-506. . View in PubMed

A controlled 2-mo dietary fat reduction and soy food supplementation study in postmenopausal women Am J Clin Nutr. 2005 May; 81(5):1133-41. . View in PubMed

Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysis J Natl Cancer Inst. 2005 Jan 05; 97(1):51-9. . View in PubMed

A candidate gene approach to searching for low-penetrance breast and prostate cancer genes Nat Rev Cancer. 2005 12; 5(12):977-85. . View in PubMed

Common variation in BRCA2 and breast cancer risk: a haplotype-based analysis in the Multiethnic Cohort Hum Mol Genet. 2004 Oct 15; 13(20):2431-41. . View in PubMed

A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic Cohort Hum Mol Genet. 2003 Oct 15; 12(20):2679-92. . View in PubMed

Bayesian spatial modeling of haplotype associations Hum Hered. 2003; 56(1-3):32-40. . View in PubMed

Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study Hum Hered. 2003; 55(1):27-36. . View in PubMed

Breast cancer in a multiethnic cohort in Hawaii and Los Angeles: risk factor-adjusted incidence in Japanese equals and in Hawaiians exceeds that in whites Cancer Epidemiol Biomarkers Prev. 2002 Sep; 11(9):795-800. . View in PubMed

Association between air pollution and lung function growth in southern California children: results from a second cohort Am J Respir Crit Care Med. 2002 Jul 01; 166(1):76-84. . View in PubMed

Breast-feeding and neuroblastoma, USA and Canada Cancer Causes Control. 2002 Jun; 13(5):401-5. . View in PubMed

Building a multigenic model of breast cancer susceptibility: CYP17 and HSD17B1 are two important candidates Cancer Res. 2001 Jan 15; 61(2):785-9. . View in PubMed

Bone marrow leukemic progenitor cell content in pediatric T-lineage acute lymphoblastic leukemia patients with an isolated extramedullary first relapse Leuk Lymphoma. 2001 Jan; 40(3-4):279-85. . View in PubMed

Allelic deletion at chromosome bands 11q14-23 is common in neuroblastoma Med Pediatr Oncol. 2001 Jan; 36(1):24-7. . View in PubMed

Comprehensive analysis of chromosome 1p deletions in neuroblastoma Med Pediatr Oncol. 2001 Jan; 36(1):32-6. . View in PubMed

Antineuronal antibodies in patients with neuroblastoma and paraneoplastic opsoclonus-myoclonus J Pediatr Hematol Oncol. 2000 Jul-Aug; 22(4):315-20. . View in PubMed

Biologic factors determine prognosis in infants with stage IV neuroblastoma: A prospective Children's Cancer Group study J Clin Oncol. 2000 Mar; 18(6):1260-8. . View in PubMed

Calibration of the dietary questionnaire for a multiethnic cohort in Hawaii and Los Angeles Am J Epidemiol. 2000 Feb 15; 151(4):358-70. . View in PubMed

A multiethnic cohort in Hawaii and Los Angeles: baseline characteristics Am J Epidemiol. 2000 Feb 15; 151(4):346-57. . View in PubMed

Biologic variables in the outcome of stages I and II neuroblastoma treated with surgery as primary therapy: a children's cancer group study J Clin Oncol. 2000 Jan; 18(1):18-26. . View in PubMed

Allelic deletion at 11q23 is common in MYCN single copy neuroblastomas Oncogene. 1999 Sep 02; 18(35):4948-57. . View in PubMed

A strategic view of randomized trial design in low-incidence paediatric cancer Stat Med. 1999 May 30; 18(10):1183-97. . View in PubMed

Comparative rates of disease progression among persons infected with the same or different HIV-1 strainsThe Transfusion Safety Study Group. J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 01; 15(2):145-50. . View in PubMed

Analysis of time to death after transplantation when transplants are only given to patients in remission Biometrics. 1996 Sep; 52(3):1079-86. . View in PubMed

Allogeneic versus autologous purged bone marrow transplantation for neuroblastoma: a report from the Childrens Cancer Group J Clin Oncol. 1994 Nov; 12(11):2382-9. . View in PubMed

Comparison of autologous and allogeneic bone marrow transplantation for neuroblastoma Prog Clin Biol Res. 1994; 385:301-7. . View in PubMed

A generalized estimating equations approach to fitting major gene models in segregation analysis of continuous phenotypes Genet Epidemiol. 1993; 10(1):61-74. . View in PubMed

An estimate of the magnitude of random errors in the DS86 dosimetry from data on chromosome aberrations and severe epilation Radiat Res. 1991 Nov; 128(2):157-69. . View in PubMed

Aggressive surgery combined with intensive chemotherapy improves survival in poor-risk neuroblastoma J Pediatr Surg. 1991 Sep; 26(9):1119-23; discussion 1123-4. . View in PubMed

Allowing for dose-estimation errors for the A-bomb survivor data J Radiat Res. 1991 Mar; 32 Suppl:108-21. . View in PubMed

Allowing for random errors in radiation dose estimates for the atomic bomb survivor data Radiat Res. 1990 Sep; 123(3):275-84. . View in PubMed

Analysis of the DS86 atomic bomb radiation dosimetry methods using data on severe epilation Radiat Res. 1989 Jan; 117(1):93-113. . View in PubMed

Analysing repeated measurements with possibly missing observations by modelling marginal distributions Stat Med. 1988 Jan-Feb; 7(1-2):139-48. . View in PubMed

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