Faculty

Joshua Millstein, PhD
Joshua Millstein, PhD
Assistant Professor of Research Preventive Medicine
Preventive Medicine
SSB 202N 2001 N. Soto Street Health Sciences Campus Los Angeles
Dr. Millstein’s research is focused on developing and applying statistical methods to address the many challenges of high dimensional data, particularly in multi-omic population-based studies of the genome, epigenome, transcriptome, microbiome, etc., in the context of pathogenesis of complex diseases such as cancer. With massive amounts of data collected in typical studies due to these advancing technologies, it has become increasingly important to have computational tools able to sift through all the information to separate the signal of interest from the noise. Specific areas of methods development include, causal mediation (CIT), dimensionality reduction, causal networks, false discovery rates (FDR), and epistasis/statistical interactions.

High intake of dietary fructose in overweight/obese teenagers associated with depletion of Eubacterium and Streptococcus in gut microbiome Gut Microbes. 2019 Apr 16; 1-8. . View in PubMed

Impact of polymorphisms within genes involved in regulating DNA methylation in patients with metastatic colorectal cancer enrolled in three independent, randomised, open-label clinical trials: a meta-analysis from TRIBE, MAVERICC and FIRE-3 Eur J Cancer. 2019 Apr; 111:138-147. . View in PubMed

AMPK variant, a candidate of novel predictor for chemotherapy in metastatic colorectal cancer: A meta-analysis using TRIBE, MAVERICC and FIRE3 Int J Cancer. 2019 Mar 11. . View in PubMed

Impact of polymorphisms within genes involved in regulating DNA methylation in patients with metastatic colorectal cancer enrolled in three independent, randomised, open-label clinical trials: a meta-analysis from TRIBE, MAVERICC and FIRE-3 Eur J Cancer. 2019 Mar 07; 111:138-147. . View in PubMed

Genetic-Epigenetic Interactions in Asthma Revealed by a Genome-Wide Gene-Centric Search Hum Hered. 2019 Jan 22; 83(3):130-152. . View in PubMed

Prognostic Effect of Adenosine-related Genetic Variants in Metastatic Colorectal Cancer Treated With Bevacizumab-based Chemotherapy Clin Colorectal Cancer. 2019 03; 18(1):e8-e19. . View in PubMed

Association between AXL promoter methylation and lung function growth during adolescence Epigenetics. 2018 Oct 02; 1-12. . View in PubMed

Association between AXL promoter methylation and lung function growth during adolescence Epigenetics. 2018 Oct 02. . View in PubMed

Prognostic Effect of Adenosine-related Genetic Variants in Metastatic Colorectal Cancer Treated With Bevacizumab-based Chemotherapy Clin Colorectal Cancer. 2018 Sep 13. . View in PubMed

Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes Clin Epigenetics. 2018 Jul 20; 10(1):98. . View in PubMed

Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB)/ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) expression quantitative trait locusJ Allergy Clin Immunol. 2018 Jun; 141(6):2282-2286. e6. . View in PubMed

Single-Cell Digital Lysates Generated by Phase-Switch Microfluidic Device Reveal Transcriptome Perturbation of Cell Cycle ACS Nano. 2018 May 22; 12(5):4687-4694. . View in PubMed

Single-Cell Digital Lysates Generated by Phase-Switch Microfluidic Device Reveal Transcriptome Perturbation of Cell Cycle ACS Nano. 2018 Apr 18. . View in PubMed

Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes Clin Epigenetics. 2018 07 20; 10(1):98. . View in PubMed

Genetic-Epigenetic Interactions in Asthma Revealed by a Genome-Wide Gene-Centric Search Hum Hered. 2018; 83(3):130-152. . View in PubMed

Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control Am J Respir Crit Care Med. 2017 Jan 15; 195(2):179-188. . View in PubMed

Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control Am J Respir Crit Care Med. 2017 01 15; 195(2):179-188. . View in PubMed

Epigenetic regulation of AXL and risk of childhood asthma symptoms Clin Epigenetics. 2017; 9:121. . View in PubMed

Prenatal Air Pollution Exposures, DNA Methyl Transferase Genotypes, and Associations with Newborn LINE1 and Alu Methylation and Childhood Blood Pressure and Carotid Intima-Media Thickness in the Children's Health Study Environ Health Perspect. 2016 12; 124(12):1905-1912. . View in PubMed

cit: hypothesis testing software for mediation analysis in genomic applications Bioinformatics. 2016 08 01; 32(15):2364-5. . View in PubMed

NPPB is a novel candidate biomarker expressed by cancer-associated fibroblasts in epithelial ovarian cancer Int J Cancer. 2015 Mar 15; 136(6):1390-401. . View in PubMed

Alteration of select gene expression patterns in individuals infected with HIV-1 J Med Virol. 2014 Apr; 86(4):678-86. . View in PubMed

Computationally efficient permutation-based confidence interval estimation for tail-area FDR Front Genet. 2013; 4:179. . View in PubMed

Screening-testing approaches for gene-gene and gene-environment interactions using independent statistics Front Genet. 2013; 4:306. . View in PubMed

Mapping the genetic architecture of gene expression in human liver PLoS Biol. 2008 May 06; 6(5):e107. . View in PubMed

Health effects of the 2003 Southern California wildfires on children Am J Respir Crit Care Med. 2006 Dec 01; 174(11):1221-8. . View in PubMed

A testing framework for identifying susceptibility genes in the presence of epistasis Am J Hum Genet. 2006 Jan; 78(1):15-27. . View in PubMed

Identifying susceptibility genes by using joint tests of association and linkage and accounting for epistasis BMC Genet. 2005 Dec 30; 6 Suppl 1:S147. . View in PubMed

Birth outcomes and prenatal exposure to ozone, carbon monoxide, and particulate matter: results from the Children's Health Study Environ Health Perspect. 2005 Nov; 113(11):1638-44. . View in PubMed

Testing association and linkage using affected-sib-parent study designs Genet Epidemiol. 2005 Nov; 29(3):225-33. . View in PubMed

Effects of ambient air pollutants on asthma medication use and wheezing among fourth-grade school children from 12 Southern California communities enrolled in The Children's Health Study Arch Environ Health. 2004 Oct; 59(10):505-14. . View in PubMed

Comparison of age-length and growth-increment general growth models of the Schnute type in the Pacific Blue Mussel, Mytilus trossulus Gould J Exp Mar Bio Ecol. 2001 Jul 30; 262(2):155-176. . View in PubMed

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