Southern California Research Center for ALPD and Cirrhosis

Southern California Research Center for ALPD and Cirrhosis 2018-03-01T10:33:22+00:00

The Southern California Research Center for ALPD & Cirrhosis

Funded in 1999 by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the Southern California Research Center for Alcoholic Liver and Pancreatic Diseases (ALPD) and Cirrhosis unifies 65 investigators from major academic institutions in Southern California to pursue a common mission of being a leader in research, training, and outreach for the diseases. The center, since its inception in 1999, has devoted its efforts for development and use of clinically relevant animal models to gain novel insights into the molecular mechanisms underlying the predisposition to advanced ALPD. These efforts culminated in recent groundbreaking discoveries which have significantly advanced our understanding of synergistic ALPD caused by alcohol and a second hit.
Hidekazu Tsukamoto, PhD

Hidekazu Tsukamoto, PhD
Professor of Pathology

From 2013 to 2017, the center’s interactive environment and infrastructure have facilitated a 187 percent increase in research base to $16.3M/year; 13 new U01/P01 programs; 219 publications; generation of 12 NIH-funded early-stage investigators; transition of eight postdocs to faculty positions; education for 179 graduate students and research fellowships for 38 undergraduate/masters students; and organization of two community seminars and four international symposia. As a unique national resource, the center’s Animal Core has provided scientific communities across the nation with 4075 rodents as 21 different ALPD and cirrhosis models for 30 center members and 13 non-center investigators. The Animal Core also provided 555 model samples to 27 non-center investigators. These activities supported 85 publications by center members and four publications by non-center investigators, 41 grants acquired by 21 center members and 29 grants acquired/applied by 22 non-center investigators.

The center’s Integrative Live Cell Core provided 2388 cell isolations for 39 investigators from 16 institutions, supporting 34 publications and 19 federal grant acquisitions.

Mission of the Center

The center’s mission statement: Integrate liver and pancreas experts in Southern California to best serve the nation as a unique scientific center of excellence in ALPD and cirrhosis.

Toward this mission, we pursue the following objectives:

  1. To maximize our interactive and synergistic environment for a pursuit for the center’s main research theme: identification of therapeutic targets for advanced ALPD and cirrhosis
  2. To continue to serve as a national and international resource in our fields of research via provision of unique models, technology and expertise, as well as collaborations with outside investigators
  3. To provide comprehensive education and research training at the multi-levels ranging from undergraduate and graduate students to postdoctoral trainees to junior scientists and faculty to foster and support future generations of independent scientists in the ALPD and cirrhosis field
  4. To continue outreach efforts to disseminate the center’s new findings to lay public, healthcare workers, and scientists in our home and global communities

Key Center researchers are academically affiliated with renowned institutions such as the University of Southern California (USC), Cedars-Sinai, University of California, Los Angeles (UCLA), University of California, San Diego (UCSD), University of California, Irvine (UCI), Loma Linda University, Harbor-UCLA Medical Center, and the Department of Veterans Affairs.

ALDP distribution map

The Research Center is supported by grants (P50 AA011999, R13 AA020691 and R24 AA012885) from the National Institute on Alcohol Abuse and Alcoholism(NIAAA) and by the Keck School of Medicine of the University of Southern California and provides Unique Scientific Services that Supports Scientists around the world

The Center provides unique expertise to the scientific community through its Core Services. The Animal Core provides the rodent models of intragastric ethanol infusion (iG) as well as animal models for cirrhosis. The Integrative Liver Cell Core provides freshly isolated or cultured cells.
More Information and Fee Schedules

International Symposium on ALPD & Cirrhosis for future and past events.
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Major Scientific Breakthroughs by the Center Investigators.
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Support the Center: Learn how to support our research….
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