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Brian Applegate, PhD

Professor of Otolaryngology - Head & Neck Surgery, Ophthalmology, Biomedical Engineering and Electrical and Computer Engineering

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Overview

Our research interests are broadly to develop novel biophotonic technologies for point-of-care diagnosis and monitoring of human disease as well as the basic scientific understanding of human disease.

Education and Training

  • The Ohio State University, Columbus, OH — PhD — 12/2000 — Chemistry

Research Funding

  • New technologies for imaging of the human cochlea
    NIH · R01DC023511 · Jul 1, 2026 – Apr 30, 2031 · Role: Principal Investigator
  • New low cost technology for early detection of ear disorders
    NIH · R21DC023404 · Sep 17, 2025 – Aug 31, 2027 · Role: Principal Investigator
  • Ultra-stable, phase sensitive, snapshot OCT system enabled by 2-Photon additive manufacturing
    NIH · R21GM149078 · Sep 15, 2023 – Aug 31, 2025 · Role: Principal Investigator
  • High-Speed, Low-Cost, Image Remapping Spectral Domain Full-Field Optical Coherence Tomography for Retinal Imaging
    NIH · R21EY035108 · Jul 1, 2023 – Jun 30, 2025 · Role: Principal Investigator
  • Comb Light Source/Imaging spectrometer for advanced Spectral Domain Optical Coherence Tomography
    NIH · R21GM135530 · Sep 1, 2020 – Aug 31, 2022 · Role: Principal Investigator
  • Optical imaging technologies to identify residual cholesteatoma and improve ossiculoplasty outcomes
    NIH · R01EB027113 · Apr 1, 2019 – Dec 31, 2023 · Role: Principal Investigator
  • Morphological and Molecular Imaging System for in vivo Atherosclerosis Research
    NIH · R01HL111361 · Apr 1, 2012 – Mar 31, 2019 · Role: Principal Investigator
  • Development of high-resolution molecular imaging of endogenous chromophores with
    NIH · R21RR025799 · May 15, 2009 – Apr 30, 2013 · Role: Principal Investigator
  • New Technologies for high resolution optical molecular imaging
    NIH · R21EB007729 · Jun 1, 2008 – May 31, 2011 · Role: Principal Investigator
  • Bringing Molecular Contrast to OCT
    NIH · F32EB004237 · Sep 1, 2004 – Aug 31, 2006 · Role: Principal Investigator

Publications

  • Vibration of the organ of Corti within the cochlear apex in mice. J Neurophysiol. 2014 Sep 01; 112(5):1192-204.. View in PubMed
  • Molecular specificity in photoacoustic microscopy by time-resolved transient absorption. Opt Lett. 2014 Jun 01; 39(11):3102-5.. View in PubMed
  • In vivo pump-probe optical coherence tomography imaging in Xenopus laevis. J Biophotonics. 2015 Jan; 8(1-2):25-35.. View in PubMed
  • Volumetric imaging of erythrocytes using label-free multiphoton photoacoustic microscopy. J Biophotonics. 2014 Oct; 7(10):834-40.. View in PubMed
  • Continuous real-time photoacoustic demodulation via field programmable gate array for dynamic imaging of zebrafish cardiac cycle. Biomed Opt Express. 2013; 4(8):1451-63.. View in PubMed
  • Chromatic confocal microscopy for multi-depth imaging of epithelial tissue. Biomed Opt Express. 2013 May 01; 4(5):732-40.. View in PubMed
  • In vivo vibrometry inside the apex of the mouse cochlea using spectral domain optical coherence tomography. Biomed Opt Express. 2013 Feb 01; 4(2):230-40.. View in PubMed
  • Application of non-negative matrix factorization to multispectral FLIM data analysis. Biomed Opt Express. 2012 Sep 01; 3(9):2244-62.. View in PubMed
  • Imaging high-frequency periodic motion in the mouse ear with coherently interleaved optical coherence tomography. Opt Lett. 2011 Dec 01; 36(23):4716-8.. View in PubMed
  • Biochemical characterization of atherosclerotic plaques by endogenous multispectral fluorescence lifetime imaging microscopy. Atherosclerosis. 2012 Feb; 220(2):394-401.. View in PubMed

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