Christopher Ching

Assistant Professor Of Research Neurology

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Overview

Dr. Ching is an Assistant Professor at The Imaging Genetics Center, part of the Mark and Mary Stevens Neuroimaging and Informatics Institute, where his research focuses on neuroimaging and genomic markers of psychiatric and neurodegenerative disorders. As a core organizing member of the Enhancing Neuro Imaging Genetics through Meta-Analysis Consortium (ENIGMA), he designs and implements standardized processing and analysis techniques for large-scale, international neuroimaging studies for a wide range of brain conditions. He leads the ENIGMA Bipolar Disorder Working Group, an effort including >200 researchers from around the world pooling data and resources to improve our understanding of the biological processes driving bipolar disorder. In complementary work, he studies rare copy number variants like 22q11.2 Deletion Syndrome to understand how certain rare genetic mutations can lead to increased risk for developing psychiatric illness. Finally, he leads several large-scale transdiagnostic neuroimaging and genomic initiatives mapping the common and distinct brain and clinical factors across a range of serious mental illnesses.

Awards

  • USC: Postdoctoral Fellowship in Biomarkers in Alzheimer’s Disease NIAT32AG058507, 2019
     – 2021
  • UCLA: Neurobehavioral Genetics Predoctoral Fellowship, NIH/NIMH 5T32MH073526, 2015
     – 2016
  • UCLA: Neuroimaging Training Program, National Institutes of Health, R90 DA022768 and T90 DA023422, 2012
     – 2013
  • UCLA: National Science Foundation Alliance for Graduate Education and the Professoriate Grant, 2012
     – 2012

Education and Training

  • UCLA — PhD — Neuroscience
  • Pomona College — BA — Neuroscience/Philosophy

Research Keywords

  • Neuroscience
  • Neuoroimaging
  • Psychiatric Disorders
  • Genetics
  • Neurodegenerative Disease

Publications

  • Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries. Nat Genet. 2024 Nov; 56(11):2333-2344.. View in PubMed
  • Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries. medRxiv. 2024 Aug 15.. View in PubMed
  • ENIGMA-Chronic Pain: a worldwide initiative to identify brain correlates of chronic pain. Pain. 2024 Dec 01; 165(12):2662-2666.. View in PubMed
  • Principal component analysis as an efficient method for capturing multivariate brain signatures of complex disorders-ENIGMA study in people with bipolar disorders and obesity. Hum Brain Mapp. 2024 06 01; 45(8):e26682.. View in PubMed
  • Effects of gene dosage and development on subcortical nuclei volumes in individuals with 22q11.2 copy number variations. Neuropsychopharmacology. 2024 May; 49(6):1024-1032.. View in PubMed
  • Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures. Sci Rep. 2024 01 11; 14(1):1084.. View in PubMed
  • Source-based morphometry reveals structural brain pattern abnormalities in 22q11.2 deletion syndrome. Hum Brain Mapp. 2024 01; 45(1):e26553.. View in PubMed
  • Large-Scale Neuroimaging of Mental Illness. Curr Top Behav Neurosci. 2024; 68:371-397.. View in PubMed
  • Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods. Neuropsychopharmacology. 2024 Feb; 49(3):609-619.. View in PubMed
  • Social Media and Website Use: The Experiences of Parents and Carers Accessing Care at the Oxford Craniofacial Unit. J Craniofac Surg. 2024 Jan-Feb 01; 35(1):104-110.. View in PubMed