Christopher Ching

Assistant Professor Of Research Neurology

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Overview

Dr. Ching is an Assistant Professor at The Imaging Genetics Center, part of the Mark and Mary Stevens Neuroimaging and Informatics Institute, where his research focuses on neuroimaging and genomic markers of psychiatric and neurodegenerative disorders. As a core organizing member of the Enhancing Neuro Imaging Genetics through Meta-Analysis Consortium (ENIGMA), he designs and implements standardized processing and analysis techniques for large-scale, international neuroimaging studies for a wide range of brain conditions. He leads the ENIGMA Bipolar Disorder Working Group, an effort including >200 researchers from around the world pooling data and resources to improve our understanding of the biological processes driving bipolar disorder. In complementary work, he studies rare copy number variants like 22q11.2 Deletion Syndrome to understand how certain rare genetic mutations can lead to increased risk for developing psychiatric illness. Finally, he leads several large-scale transdiagnostic neuroimaging and genomic initiatives mapping the common and distinct brain and clinical factors across a range of serious mental illnesses.

Awards

  • USC: Postdoctoral Fellowship in Biomarkers in Alzheimer’s Disease NIAT32AG058507, 2019
     – 2021
  • UCLA: Neurobehavioral Genetics Predoctoral Fellowship, NIH/NIMH 5T32MH073526, 2015
     – 2016
  • UCLA: Neuroimaging Training Program, National Institutes of Health, R90 DA022768 and T90 DA023422, 2012
     – 2013
  • UCLA: National Science Foundation Alliance for Graduate Education and the Professoriate Grant, 2012
     – 2012

Education and Training

  • UCLA — PhD — Neuroscience
  • Pomona College — BA — Neuroscience/Philosophy

Research Keywords

  • Neuroscience
  • Neuoroimaging
  • Psychiatric Disorders
  • Genetics
  • Neurodegenerative Disease

Publications

  • Effects of Gene Dosage and Development on Subcortical Nuclei Volumes in Individuals with 22q11.2 Copy Number Variations. bioRxiv. 2023 Nov 01.. View in PubMed
  • Multi-Site Statistical Mapping of Along-Tract Microstructural Abnormalities in Bipolar Disorder with Diffusion MRI Tractometry. bioRxiv. 2023 Oct 25.. View in PubMed
  • Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers. Biol Psychiatry. 2024 01 15; 95(2):147-160.. View in PubMed
  • Subcortical Brain Alterations in Carriers of Genomic Copy Number Variants. Am J Psychiatry. 2023 09 01; 180(9):685-698.. View in PubMed
  • Preliminary validation of a structural magnetic resonance imaging metric for tracking dementia-related neurodegeneration and future decline. Neuroimage Clin. 2023; 39:103458.. View in PubMed
  • Mega-analysis of association between obesity and cortical morphology in bipolar disorders: ENIGMA study in 2832 participants. Psychol Med. 2023 10; 53(14):6743-6753.. View in PubMed
  • Subcortical brain alterations in carriers of genomic copy number variants. medRxiv. 2023 Feb 22.. View in PubMed
  • Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group. Mol Psychiatry. 2023 03; 28(3):1079-1089.. View in PubMed
  • Harmonization of multi-scanner in vivo magnetic resonance spectroscopy: ENIGMA consortium task group considerations. Front Neurol. 2022; 13:1045678.. View in PubMed
  • Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders. Nat Commun. 2022 11 11; 13(1):6851.. View in PubMed