Christopher Ching

Assistant Professor Of Research Neurology

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Overview

Dr. Ching is an Assistant Professor at The Imaging Genetics Center, part of the Mark and Mary Stevens Neuroimaging and Informatics Institute, where his research focuses on neuroimaging and genomic markers of psychiatric and neurodegenerative disorders. As a core organizing member of the Enhancing Neuro Imaging Genetics through Meta-Analysis Consortium (ENIGMA), he designs and implements standardized processing and analysis techniques for large-scale, international neuroimaging studies for a wide range of brain conditions. He leads the ENIGMA Bipolar Disorder Working Group, an effort including >200 researchers from around the world pooling data and resources to improve our understanding of the biological processes driving bipolar disorder. In complementary work, he studies rare copy number variants like 22q11.2 Deletion Syndrome to understand how certain rare genetic mutations can lead to increased risk for developing psychiatric illness. Finally, he leads several large-scale transdiagnostic neuroimaging and genomic initiatives mapping the common and distinct brain and clinical factors across a range of serious mental illnesses.

Awards

  • USC: Postdoctoral Fellowship in Biomarkers in Alzheimer’s Disease NIAT32AG058507, 2019
     – 2021
  • UCLA: Neurobehavioral Genetics Predoctoral Fellowship, NIH/NIMH 5T32MH073526, 2015
     – 2016
  • UCLA: Neuroimaging Training Program, National Institutes of Health, R90 DA022768 and T90 DA023422, 2012
     – 2013
  • UCLA: National Science Foundation Alliance for Graduate Education and the Professoriate Grant, 2012
     – 2012

Education and Training

  • UCLA — PhD — Neuroscience
  • Pomona College — BA — Neuroscience/Philosophy

Research Keywords

  • Neuroscience
  • Neuoroimaging
  • Psychiatric Disorders
  • Genetics
  • Neurodegenerative Disease

Publications

  • Genomic and neuroimaging approaches to bipolar disorder. BJPsych Open. 2022 Feb 01; 8(2):e36.. View in PubMed
  • ENIGMA + COINSTAC: Improving Findability, Accessibility, Interoperability, and Re-usability. Neuroinformatics. 2022 01; 20(1):261-275.. View in PubMed
  • Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group. Biol Psychiatry. 2022 03 15; 91(6):582-592.. View in PubMed
  • A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium. Hum Brain Mapp. 2022 01; 43(1):352-372.. View in PubMed
  • Prioritizing Genetic Contributors to Cortical Alterations in 22q11.2 Deletion Syndrome Using Imaging Transcriptomics. Cereb Cortex. 2021 06 10; 31(7):3285-3298.. View in PubMed
  • Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals. Mol Psychiatry. 2021 11; 26(11):6806-6819.. View in PubMed
  • Structural and functional brain alterations revealed by neuroimaging in CNV carriers. Curr Opin Genet Dev. 2021 06; 68:88-98.. View in PubMed
  • 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans. Transl Psychiatry. 2021 03 22; 11(1):182.. View in PubMed
  • Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs. Hum Brain Mapp. 2022 01; 43(1):300-328.. View in PubMed
  • Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years. Hum Brain Mapp. 2022 01; 43(1):431-451.. View in PubMed