Frank Attenello, MD, MS

Associate Professor of Clinical Neurological Surgery and Cancer Biology

Sloan Family Endowed Professorship in Neurological Surgery

Image of Frank Attenello, MD, MS
Is this your profile? Click to edit

Overview

Frank Attenello MD, MS is the Sloan Family Endowed Associate Professor of Neurosurgery, Biochemistry and Molecular Medicine at the Keck School of Medicine of USC, specializing in treatment of primary and metastatic brain tumors. He employs multiple surgical modalities to preserve neurologic function in tumor surgery including minimally invasive subcortical surgery (BrainPath) and laser interstitial thermal therapy. Dr. Attenello performs both cranial surgery and stereotactic radiosurgery.

Dr. Attenello received combined BS/MS degrees in Molecular Biochemistry and Biophysics from Yale University. He then received his medical degree from Johns Hopkins University School of Medicine, where he received the institutional Harvey Cushing Neurosurgery Award and the Ronald L. Bittner national Neuro-oncology research award. His work on glioblastoma and neural stem cells at Johns Hopkins was supported by a fellowship from the Howard Hughes Medical Institute. He then completed neurosurgical residency at the University of Southern California, with a postdoctoral fellowship in tumor genetics at the University of California, San Francisco.

Dr. Attenello has authored six neurosurgical book chapters and over 150 peer-reviewed manuscripts including articles in Science, BMJ, and Cancer Discovery. He was appointed Associate Scientific Advisor for Science Translational Medicine, and is an editorial board member of the Journal of Neurosurgery and the Journal of Neuroscience Research.

Dr. Attenello is also principal investigator of a basic science research laboratory studying epigenetic regulation of glioma chemoresistance as well as role of neural stem cells in brain injury (https://sites.usc.edu/attenellolab/). His laboratory is supported by a NIH K08 Research Career Development Award and several NIH and foundational grants, including generous patient support. In addition, Dr. Attenello directs a clinical outcomes laboratory studying factors associated with improved outcome in patients with neurologic disease, as well as factors driving medical trainee burnout. Using data and experience gained in the laboratory, Dr. Attenello is identifying new therapies for improved patient outcomes.

Education and Training

  • Johns Hopkins University School of Medicine, Baltimore, MD — MD — 05/2009 — Medicine
  • Yale University, New Haven, CT — BS, MS — 06/2003 — Molecular BIophysics and Biochemistry

Publications

  • Predictors of readmission after craniotomy for meningioma resection: a nationwide readmission database analysis. Acta Neurochir (Wien). 2020 11; 162(11):2637-2646.. View in PubMed
  • Effect of Comorbid Depression on Surgical Outcomes After Craniotomy for Malignant Brain Tumors: A Nationwide Readmission Database Analysis. World Neurosurg. 2020 10; 142:e458-e473.. View in PubMed
  • Comparison of Rates and Outcomes of Readmission to Index vs Non-index Hospitals After Intravenous Thrombolysis in Acute Stroke Patients. Cureus. 2020 Jul 01; 12(7):e8952.. View in PubMed
  • Increased 30-day readmission rate after craniotomy for tumor resection at safety net hospitals in small metropolitan areas. J Neurooncol. 2020 May; 148(1):141-154.. View in PubMed
  • HOTAIRM1, an enhancer lncRNA, promotes glioma proliferation by regulating long-range chromatin interactions within HOXA cluster genes. Mol Biol Rep. 2020 Apr; 47(4):2723-2733.. View in PubMed
  • Identifying Disparities in Care in Treating Glioblastoma: A Retrospective Cohort Study of Patients Treated at a Safety-net Versus Private Hospital Setting. World Neurosurg. 2020 05; 137:e213-e220.. View in PubMed
  • Fragmentation of postpartum readmissions in the United States. Am J Obstet Gynecol. 2020 08; 223(2):252.e1-252.e14.. View in PubMed
  • A HOTAIR regulatory element modulates glioma cell sensitivity to temozolomide through long-range regulation of multiple target genes. Genome Res. 2020 02; 30(2):155-163.. View in PubMed
  • Commentary: Clinical Accuracy of Holographic Navigation Using Point-Based Registration on Augmented-Reality Glasses. Oper Neurosurg. 2019 12 01; 17(6):E229-E230.. View in PubMed
  • Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers. Cancer Discov. 2020 01; 10(1):86-103.. View in PubMed