Frank Attenello, MD, MS

Associate Professor of Clinical Neurological Surgery and Cancer Biology

Sloan Family Endowed Professorship in Neurological Surgery

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Overview

Frank Attenello MD, MS is the Sloan Family Endowed Associate Professor of Neurosurgery, Biochemistry and Molecular Medicine at the Keck School of Medicine of USC, specializing in treatment of primary and metastatic brain tumors. He employs multiple surgical modalities to preserve neurologic function in tumor surgery including minimally invasive subcortical surgery (BrainPath) and laser interstitial thermal therapy. Dr. Attenello performs both cranial surgery and stereotactic radiosurgery.

Dr. Attenello received combined BS/MS degrees in Molecular Biochemistry and Biophysics from Yale University. He then received his medical degree from Johns Hopkins University School of Medicine, where he received the institutional Harvey Cushing Neurosurgery Award and the Ronald L. Bittner national Neuro-oncology research award. His work on glioblastoma and neural stem cells at Johns Hopkins was supported by a fellowship from the Howard Hughes Medical Institute. He then completed neurosurgical residency at the University of Southern California, with a postdoctoral fellowship in tumor genetics at the University of California, San Francisco.

Dr. Attenello has authored six neurosurgical book chapters and over 150 peer-reviewed manuscripts including articles in Science, BMJ, and Cancer Discovery. He was appointed Associate Scientific Advisor for Science Translational Medicine, and is an editorial board member of the Journal of Neurosurgery and the Journal of Neuroscience Research.

Dr. Attenello is also principal investigator of a basic science research laboratory studying epigenetic regulation of glioma chemoresistance as well as role of neural stem cells in brain injury (https://sites.usc.edu/attenellolab/). His laboratory is supported by a NIH K08 Research Career Development Award and several NIH and foundational grants, including generous patient support. In addition, Dr. Attenello directs a clinical outcomes laboratory studying factors associated with improved outcome in patients with neurologic disease, as well as factors driving medical trainee burnout. Using data and experience gained in the laboratory, Dr. Attenello is identifying new therapies for improved patient outcomes.

Education and Training

  • Johns Hopkins University School of Medicine, Baltimore, MD — MD — 05/2009 — Medicine
  • Yale University, New Haven, CT — BS, MS — 06/2003 — Molecular BIophysics and Biochemistry

Publications

  • Increased complication and mortality among non-index hospital readmissions after brain tumor resection is associated with low-volume readmitting hospitals. J Neurosurg. 2020 11 01; 133(5):1332-1344.. View in PubMed
  • Risk of Stillbirth after Antepartum Hospitalization for Hypertensive Diseases of Pregnancy. Am J Perinatol. 2020 01; 37(1):66-72.. View in PubMed
  • Postpartum Psychiatric Admissions in the United States. Am J Perinatol. 2021 01; 38(2):115-121.. View in PubMed
  • Brainstem Gliomas: New Models Recapitulate Human Disease and Deepen Our Understanding. Neurosurgery. 2019 08 01; 85(2):E169-E171.. View in PubMed
  • Characterizing Glioma Genetics Using Cerebrospinal Fluid. Neurosurgery. 2019 08 01; 85(2):E196-E197.. View in PubMed
  • Frequency, predictors, and outcomes of readmission to index versus non-index hospitals after mechanical thrombectomy in patients with ischemic stroke. J Neurointerv Surg. 2020 Feb; 12(2):136-141.. View in PubMed
  • Acute Venous Thromboembolism Risk Highest Within 60 Days After Discharge From the Hospital in Patients With Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2020 05; 18(5):1133-1141.e3.. View in PubMed
  • Nonindex Readmission After Ruptured Brain Aneurysm Treatment Is Associated with Higher Morbidity and Repeat Readmission. World Neurosurg. 2019 Oct; 130:e753-e759.. View in PubMed
  • Risk for postpartum readmissions and associated complications based on maternal age. J Matern Fetal Neonatal Med. 2021 May; 34(9):1375-1381.. View in PubMed
  • Postpartum hemorrhage and risk for postpartum readmission. J Matern Fetal Neonatal Med. 2021 Jan; 34(2):187-194.. View in PubMed