Keck School Faculty

Long-term cell fate and functional maintenance of human hepatocyte through stepwise culture configuration FASEB J. 2023 02; 37(2):e22750. . View in PubMed

Fatty acid metabolism of Mycobacterium tuberculosis: A double-edged sword Microb Cell. 2022 May 02; 9(5):123-125. . View in PubMed

Publisher Correction: Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS Nat Neurosci. 2022 Feb; 25(2):264. . View in PubMed

Difluoromethylornithine (DFMO) and AMXT 1501 inhibit capsule biosynthesis in pneumococci Sci Rep. 2022 07 12; 12(1):11804. . View in PubMed

Arginine-mediated gut microbiome remodeling promotes host pulmonary immune defense against nontuberculous mycobacterial infection Gut Microbes. 2022 Jan-Dec; 14(1):2073132. . View in PubMed

The Role of Fatty Acid Metabolism in Drug Tolerance of Mycobacterium tuberculosis mBio. 2022 02 22; 13(1):e0355921. . View in PubMed

Herpesvirus-induced spermidine synthesis and eIF5A hypusination for viral episomal maintenance Cell Rep. 2022 08 16; 40(7):111234. . View in PubMed

Central carbon metabolism remodeling as a mechanism to develop drug tolerance and drug resistance in Mycobacterium tuberculosis Front Cell Infect Microbiol. 2022; 12:958240. . View in PubMed

Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS Nat Neurosci. 2021 12; 24(12):1673-1685. . View in PubMed

Transcriptomic and Metabolomic Analysis Revealed Roles of Yck2 in Carbon Metabolism and Morphogenesis of Candida albicans Front Cell Infect Microbiol. 2021; 11:636834. . View in PubMed

Phosphoenolpyruvate depletion mediates both growth arrest and drug tolerance of Mycobacterium tuberculosis in hypoxia Proc Natl Acad Sci U S A. 2021 08 31; 118(35). . View in PubMed

A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii Nat Microbiol. 2020 09; 5(9):1134-1143. . View in PubMed

Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis Proc Natl Acad Sci U S A. 2020 04 07; 117(14):8083-8093. . View in PubMed

SP_0916 Is an Arginine Decarboxylase That Catalyzes the Synthesis of Agmatine, Which Is Critical for Capsule Biosynthesis in Streptococcus pneumoniae Front Microbiol. 2020; 11:578533. . View in PubMed

Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence Sci Adv. 2019 03; 5(3):eaav2104. . View in PubMed

Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis Nat Commun. 2019 07 02; 10(1):2928. . View in PubMed

Endothelial lineage-specific interaction of Mycobacterium tuberculosis with the blood and lymphatic systems Tuberculosis (Edinb). 2018 07; 111:1-7. . View in PubMed

TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing Nat Commun. 2018 02 09; 9(1):613. . View in PubMed

Glutamate mediated metabolic neutralization mitigates propionate toxicity in intracellular Mycobacterium tuberculosis Sci Rep. 2018 05 31; 8(1):8506. . View in PubMed

Bacterial Protein Reshapes Host Defense toward Antiviral Responses Mol Cell. 2018 08 16; 71(4):483-484. . View in PubMed

Metabolic anticipation in Mycobacterium tuberculosis Nat Microbiol. 2017 May 22; 2:17084. . View in PubMed

Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis Proc Natl Acad Sci U S A. 2017 03 14; 114(11):E2225-E2232. . View in PubMed

mBio. 2017 08 15; 8(4). . View in PubMed

Effects of fluconazole on the metabolomic profile of Candida albicans J Antimicrob Chemother. 2016 Mar; 71(3):635-40. . View in PubMed

Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis Cell Rep. 2016 Jan 26; 14(3):572-585. . View in PubMed

Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis ACS Infect Dis. 2016 12 09; 2(12):958-968. . View in PubMed

Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis Nat Commun. 2015 Aug 10; 6:7912. . View in PubMed

Metabolomics: a window into the adaptive physiology of Mycobacterium tuberculosis Tuberculosis (Edinb). 2014 Dec; 94(6):538-43. . View in PubMed

Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis PLoS Pathog. 2014 May; 10(5):e1004144. . View in PubMed

Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of Mycobacterium tuberculosis on fatty acids Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):4976-81. . View in PubMed

Allostery and compartmentalization: old but not forgotten Curr Opin Microbiol. 2014 Apr; 18:23-9. . View in PubMed

Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6554-9. . View in PubMed

Co-immunization of plasmid DNA encoding IL-12 and IL-18 with Bacillus Calmette-Guérin vaccine against progressive tuberculosis Yonsei Med J. 2011 Nov; 52(6):1008-15. . View in PubMed

Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression PLoS Pathog. 2011 Sep; 7(9):e1002264. . View in PubMed

Regulation of polar peptidoglycan biosynthesis by Wag31 phosphorylation in mycobacteria BMC Microbiol. 2010 Dec 29; 10:327. . View in PubMed

Expression and validation of D-erythrulose 1-phosphate dehydrogenase from Brucella abortus: a diagnostic reagent for bovine brucellosis J Vet Diagn Invest. 2010 Jul; 22(4):524-30. . View in PubMed

Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF Chem Biol. 2010 Feb 26; 17(2):117-22. . View in PubMed

Expression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens Chem Biol. 2009 Dec 24; 16(12):1230-9. . View in PubMed

The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target Tuberculosis (Edinb). 2009 Jan; 89(1):1-11. . View in PubMed

Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase Bioorg Med Chem Lett. 2008 Oct 01; 18(19):5320-3. . View in PubMed

Chemoenzymatic synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol: A substrate for IspE Tetrahedron Lett. 2008 Jul 21; 49(29-30):4461-4463. . View in PubMed

Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development J Bacteriol. 2007 Dec; 189(24):8922-7. . View in PubMed

Antigens secreted from Mycobacterium tuberculosis: identification by proteomics approach and test for diagnostic marker Proteomics. 2004 Nov; 4(11):3299-307. . View in PubMed