Neil Kaplowitz, MD

Professor of Medicine

USC Associates/Thomas H. Brem Chair in Medicine

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Overview

Dr. Kaplowitz’s research interests include drug toxicity, signal transduction, oxidative stress, glutathione metabolism, pathogenesis of alcoholic liver disease, endoplasmic reticulum (ER) stress, and mitochondrial biogenesis.

Dr. Kaplowitz earned his medical degree from New York University School of Medicine. He then went on to complete a Gastroenterology Fellowship at Cornell University Medical College.

Awards

  • Western Gastroenterology: Research Prize, 1986
  • Association of American Physicians: Member, 1988
  • NIH: Merit Award, 1992
  • Department of Veterans Affairs: William S. Middleton Award, 1993
  • New York University School of Medicine: Solomon A. Berson Medical Alumni Achievement Award in Clinical Science, 1994
  • American Liver Foundation: Greater Los Angeles Medical Honoree, 2000
  • American Gastroenterological Association: Foundation Research Mentor Award Honoree, 2005
  • Wadworth VA Alumni Association: William H. Oldendorf Lifetime Achievement Award, 2006
  • American Association for the Study of Liver Diseases: Distinguished Achievement Award, 2006
  • Western Society of Clinical Investigation: Mayo Soley Award, 2007
  • American Liver Foundation: Distinguished Scientific Achievement Award, 2008

Research Funding

  • Targets of JNK in acute hepatotoxicity.
    NIH · R01DK126866 · Sep 18, 2020 – May 31, 2025 · Role: Principal Investigator
  • Retrograde Signaling in Alcohol-Induced Mitochondrial Stress and Biogenesis.
    NIH · R21AA017746 · Sep 15, 2008 – Aug 31, 2010 · Role: Principal Investigator
  • Cellular Mechanisms of Hepatotoxicity.
    NIH · R01DK067215 · Apr 1, 2004 – Feb 28, 2021 · Role: Principal Investigator
  • Homocysteine, ER Stress and Alcoholic Liver Injury.
    NIH · R01AA014428 · Jul 1, 2003 – Mar 31, 2015 · Role: Principal Investigator
  • USC Research Center for Liver Disease
    NIH · P30DK048522 · Mar 1, 1995 – Feb 28, 2021 · Role: Principal Investigator
  • EFFECT OF ETHANOL ON HEPATIC GSH HOMEOSTASIS
    NIH · R01AA009526 · Apr 1, 1993 – Mar 31, 2001 · Role: Principal Investigator
  • ROLE OF CYTOKINE INFLAMMATION
    NIH · R13DK044465 · Sep 30, 1991 – Aug 31, 1992 · Role: Principal Investigator
  • PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH · R01DK030312 · Feb 1, 1982 – May 31, 2005 · Role: Principal Investigator
  • PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH · R37DK030312 · Feb 1, 1982 – May 31, 2000 · Role: Principal Investigator
  • THE PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH · R01AM030312 · Feb 1, 1982 – Jan 31, 1987 · Role: Principal Investigator

Research Keywords

  • Models of acute and chronic liver disease

Publications

  • Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis. Hepatology. 2021 12; 74(6):3127-3145.. View in PubMed
  • Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity. Hepatology. 2021 12; 74(6):3486-3496.. View in PubMed
  • The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice. Acta Pharm Sin B. 2022 Jan; 12(1):182-196.. View in PubMed
  • Alcohol, Fasting, and Therapeutic Dosing of Acetaminophen: A Perfect Storm. Hepatology. 2021 05; 73(5):1634-1636.. View in PubMed
  • Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry. J Hepatol. 2021 07; 75(1):86-97.. View in PubMed
  • Clinical Characteristics and Outcome of Drug-Induced Liver Injury in the Older Patients: From the Young-Old to the Oldest-Old. Clin Pharmacol Ther. 2021 04; 109(4):1147-1158.. View in PubMed
  • REPLY. Hepatol Commun. 2020 Nov; 4(11):1725.. View in PubMed
  • Markedly Elevated Serum Aspartate Aminotransferase to Alanine Aminotransferase Ratio: A Clue to Hepatic Neoplasia. Hepatol Commun. 2020 Jul; 4(7):1099-1101.. View in PubMed
  • Acetaminophen Hepatotoxicity: Strong Offense and Weakened Defense. Hepatology. 2020 05; 71(5):1530-1532.. View in PubMed
  • Gut Microbiota and Liver Injury (I)-Acute Liver Injury. Adv Exp Med Biol. 2020; 1238:23-37.. View in PubMed