Neil Kaplowitz, MD

Professor of Medicine

USC Associates/Thomas H. Brem Chair in Medicine

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Overview

Dr. Kaplowitz’s research interests include drug toxicity, signal transduction, oxidative stress, glutathione metabolism, pathogenesis of alcoholic liver disease, endoplasmic reticulum (ER) stress, and mitochondrial biogenesis.

Dr. Kaplowitz earned his medical degree from New York University School of Medicine. He then went on to complete a Gastroenterology Fellowship at Cornell University Medical College.

Awards

  • Western Gastroenterology: Research Prize, 1986
  • Association of American Physicians: Member, 1988
  • NIH: Merit Award, 1992
  • Department of Veterans Affairs: William S. Middleton Award, 1993
  • New York University School of Medicine: Solomon A. Berson Medical Alumni Achievement Award in Clinical Science, 1994
  • American Liver Foundation: Greater Los Angeles Medical Honoree, 2000
  • American Gastroenterological Association: Foundation Research Mentor Award Honoree, 2005
  • Wadworth VA Alumni Association: William H. Oldendorf Lifetime Achievement Award, 2006
  • American Association for the Study of Liver Diseases: Distinguished Achievement Award, 2006
  • Western Society of Clinical Investigation: Mayo Soley Award, 2007
  • American Liver Foundation: Distinguished Scientific Achievement Award, 2008

Research Funding

  • Targets of JNK in acute hepatotoxicity.
    NIH · R01DK126866 · Sep 18, 2020 – May 31, 2025 · Role: Principal Investigator
  • Retrograde Signaling in Alcohol-Induced Mitochondrial Stress and Biogenesis.
    NIH · R21AA017746 · Sep 15, 2008 – Aug 31, 2010 · Role: Principal Investigator
  • Cellular Mechanisms of Hepatotoxicity.
    NIH · R01DK067215 · Apr 1, 2004 – Feb 28, 2021 · Role: Principal Investigator
  • Homocysteine, ER Stress and Alcoholic Liver Injury.
    NIH · R01AA014428 · Jul 1, 2003 – Mar 31, 2015 · Role: Principal Investigator
  • USC Research Center for Liver Disease
    NIH · P30DK048522 · Mar 1, 1995 – Feb 28, 2021 · Role: Principal Investigator
  • EFFECT OF ETHANOL ON HEPATIC GSH HOMEOSTASIS
    NIH · R01AA009526 · Apr 1, 1993 – Mar 31, 2001 · Role: Principal Investigator
  • ROLE OF CYTOKINE INFLAMMATION
    NIH · R13DK044465 · Sep 30, 1991 – Aug 31, 1992 · Role: Principal Investigator
  • PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH · R01DK030312 · Feb 1, 1982 – May 31, 2005 · Role: Principal Investigator
  • PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH · R37DK030312 · Feb 1, 1982 – May 31, 2000 · Role: Principal Investigator
  • THE PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH · R01AM030312 · Feb 1, 1982 – Jan 31, 1987 · Role: Principal Investigator

Research Keywords

  • Models of acute and chronic liver disease

Publications

  • Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury. J Clin Invest. 2019 12 02; 129(12):5278-5293.. View in PubMed
  • IgG:IgM Ratios of Liver Plasma Cells Reveal Similar Phenotypes of Primary Biliary Cholangitis With and Without Features of Autoimmune Hepatitis. Clin Gastroenterol Hepatol. 2021 02; 19(2):397-399.. View in PubMed
  • Intestinal Epithelial Chemokine (C-C Motif) Ligand 7 Overexpression Enhances Acetaminophen-Induced Hepatotoxicity in Mice. Am J Pathol. 2020 01; 190(1):57-67.. View in PubMed
  • Drug-induced liver injury. Nat Rev Dis Primers. 2019 08 22; 5(1):58.. View in PubMed
  • Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure. Gastroenterology. 2019 08; 157(2):552-568.. View in PubMed
  • The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects. Int J Mol Sci. 2018 Nov 20; 19(11).. View in PubMed
  • Niacin-Induced Anicteric Microvesicular Steatotic Acute Liver Failure. Hepatol Commun. 2018 Nov; 2(11):1293-1298.. View in PubMed
  • Glycycoumarin protects mice against acetaminophen-induced liver injury predominantly via activating sustained autophagy. Br J Pharmacol. 2018 10; 175(19):3747-3757.. View in PubMed
  • Herb-Induced Liver Injury: A Global Concern. Chin J Integr Med. 2018 Sep; 24(9):643-644.. View in PubMed
  • New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases. Hepatology. 2018 05; 67(5):2013-2024.. View in PubMed