Neil Kaplowitz, MD

Professor of Medicine

USC Associates/Thomas H. Brem Chair in Medicine

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Overview

Dr. Kaplowitz’s research interests include drug toxicity, signal transduction, oxidative stress, glutathione metabolism, pathogenesis of alcoholic liver disease, endoplasmic reticulum (ER) stress, and mitochondrial biogenesis.

Dr. Kaplowitz earned his medical degree from New York University School of Medicine. He then went on to complete a Gastroenterology Fellowship at Cornell University Medical College.

Awards

  • Western Gastroenterology: Research Prize, 1986
  • Association of American Physicians: Member, 1988
  • NIH: Merit Award, 1992
  • Department of Veterans Affairs: William S. Middleton Award, 1993
  • New York University School of Medicine: Solomon A. Berson Medical Alumni Achievement Award in Clinical Science, 1994
  • American Liver Foundation: Greater Los Angeles Medical Honoree, 2000
  • American Gastroenterological Association: Foundation Research Mentor Award Honoree, 2005
  • Wadworth VA Alumni Association: William H. Oldendorf Lifetime Achievement Award, 2006
  • American Association for the Study of Liver Diseases: Distinguished Achievement Award, 2006
  • Western Society of Clinical Investigation: Mayo Soley Award, 2007
  • American Liver Foundation: Distinguished Scientific Achievement Award, 2008

Research Funding

  • Targets of JNK in acute hepatotoxicity.
    NIH · R01DK126866 · Sep 18, 2020 – May 31, 2025 · Role: Principal Investigator
  • Retrograde Signaling in Alcohol-Induced Mitochondrial Stress and Biogenesis.
    NIH · R21AA017746 · Sep 15, 2008 – Aug 31, 2010 · Role: Principal Investigator
  • Cellular Mechanisms of Hepatotoxicity.
    NIH · R01DK067215 · Apr 1, 2004 – Feb 28, 2021 · Role: Principal Investigator
  • Homocysteine, ER Stress and Alcoholic Liver Injury.
    NIH · R01AA014428 · Jul 1, 2003 – Mar 31, 2015 · Role: Principal Investigator
  • USC Research Center for Liver Disease
    NIH · P30DK048522 · Mar 1, 1995 – Feb 28, 2021 · Role: Principal Investigator
  • EFFECT OF ETHANOL ON HEPATIC GSH HOMEOSTASIS
    NIH · R01AA009526 · Apr 1, 1993 – Mar 31, 2001 · Role: Principal Investigator
  • ROLE OF CYTOKINE INFLAMMATION
    NIH · R13DK044465 · Sep 30, 1991 – Aug 31, 1992 · Role: Principal Investigator
  • PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH · R01DK030312 · Feb 1, 1982 – May 31, 2005 · Role: Principal Investigator
  • PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH · R37DK030312 · Feb 1, 1982 – May 31, 2000 · Role: Principal Investigator
  • THE PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH · R01AM030312 · Feb 1, 1982 – Jan 31, 1987 · Role: Principal Investigator

Research Keywords

  • Models of acute and chronic liver disease

Publications

  • Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol. 2018 07; 69(1):51-59.. View in PubMed
  • Prediction of histologic alcoholic hepatitis based on clinical presentation limits the need for liver biopsy. Hepatol Commun. 2017 12; 1(10):1070-1084.. View in PubMed
  • Heparan sulfate promotes recovery from acute liver injury: Inhibition of progressive cell death or enhanced regeneration? Hepatology. 2017 11; 66(5):1381-1383. Apte U, Kaplowitz N . . View in PubMed
  • The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading. Redox Biol. 2018 04; 14:164-177.. View in PubMed
  • Death and liver transplantation within 2 years of onset of drug-induced liver injury. Hepatology. 2017 10; 66(4):1275-1285.. View in PubMed
  • The role of MAP2 kinases and p38 kinase in acute murine liver injury models. Cell Death Dis. 2017 06 29; 8(6):e2903.. View in PubMed
  • Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis. Int J Mol Sci. 2017 May 09; 18(5).. View in PubMed
  • Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proc Natl Acad Sci U S A. 2017 04 04; 114(14):E2862-E2871.. View in PubMed
  • Protective role of p53 in acetaminophen hepatotoxicity. Free Radic Biol Med. 2017 05; 106:111-117.. View in PubMed
  • Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments. PLoS Comput Biol. 2016 12; 12(12):e1005253.. View in PubMed