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Brian Applegate, PhD

Professor of Otolaryngology - Head & Neck Surgery, Ophthalmology, Biomedical Engineering and Electrical and Computer Engineering

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Overview

Our research interests are broadly to develop novel biophotonic technologies for point-of-care diagnosis and monitoring of human disease as well as the basic scientific understanding of human disease.

Education and Training

  • The Ohio State University, Columbus, OH — PhD — 12/2000 — Chemistry

Research Funding

  • New technologies for imaging of the human cochlea
    NIH · R01DC023511 · Jul 1, 2026 – Apr 30, 2031 · Role: Principal Investigator
  • New low cost technology for early detection of ear disorders
    NIH · R21DC023404 · Sep 17, 2025 – Aug 31, 2027 · Role: Principal Investigator
  • Ultra-stable, phase sensitive, snapshot OCT system enabled by 2-Photon additive manufacturing
    NIH · R21GM149078 · Sep 15, 2023 – Aug 31, 2025 · Role: Principal Investigator
  • High-Speed, Low-Cost, Image Remapping Spectral Domain Full-Field Optical Coherence Tomography for Retinal Imaging
    NIH · R21EY035108 · Jul 1, 2023 – Jun 30, 2025 · Role: Principal Investigator
  • Comb Light Source/Imaging spectrometer for advanced Spectral Domain Optical Coherence Tomography
    NIH · R21GM135530 · Sep 1, 2020 – Aug 31, 2022 · Role: Principal Investigator
  • Optical imaging technologies to identify residual cholesteatoma and improve ossiculoplasty outcomes
    NIH · R01EB027113 · Apr 1, 2019 – Dec 31, 2023 · Role: Principal Investigator
  • Morphological and Molecular Imaging System for in vivo Atherosclerosis Research
    NIH · R01HL111361 · Apr 1, 2012 – Mar 31, 2019 · Role: Principal Investigator
  • Development of high-resolution molecular imaging of endogenous chromophores with
    NIH · R21RR025799 · May 15, 2009 – Apr 30, 2013 · Role: Principal Investigator
  • New Technologies for high resolution optical molecular imaging
    NIH · R21EB007729 · Jun 1, 2008 – May 31, 2011 · Role: Principal Investigator
  • Bringing Molecular Contrast to OCT
    NIH · F32EB004237 · Sep 1, 2004 – Aug 31, 2006 · Role: Principal Investigator

Publications

  • High-speed spectral calibration by complex FIR filter in phase-sensitive optical coherence tomography. Biomed Opt Express. 2016 Apr 01; 7(4):1430-44.. View in PubMed
  • Optical Coherence Tomography to Measure Sound-Induced Motions Within the Mouse Organ of Corti In Vivo. Methods Mol Biol. 2016; 1427:449-62.. View in PubMed
  • Miniature, minimally invasive, tunable endoscope for investigation of the middle ear. Biomed Opt Express. 2015 Jun 01; 6(6):2246-57.. View in PubMed
  • In vivo molecular contrast OCT imaging of methylene blue. Opt Lett. 2015 Apr 01; 40(7):1426-9.. View in PubMed
  • Noninvasive in vivo imaging reveals differences between tectorial membrane and basilar membrane traveling waves in the mouse cochlea. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):3128-33.. View in PubMed
  • Simultaneous morphological and biochemical endogenous optical imaging of atherosclerosis. Eur Heart J Cardiovasc Imaging. 2015 Aug; 16(8):910-8.. View in PubMed
  • Phase-sensitive optical coherence tomography using an Vernier-tuned distributed Bragg reflector swept laser in the mouse middle ear. Opt Lett. 2014 Nov 01; 39(21):6233-6.. View in PubMed
  • Automated classification of optical coherence tomography images for the diagnosis of oral malignancy in the hamster cheek pouch. J Biomed Opt. 2014 Aug; 19(8):086022.. View in PubMed
  • Simplified method for ultra high-resolution photoacoustic microscopy via transient absorption. Opt Lett. 2014 Aug 01; 39(15):4474-7.. View in PubMed
  • Molecular Imaging in Optical Coherence Tomography. Curr Mol Imaging. 2014 Jul 01; 3(2):88-105.. View in PubMed

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