Research Highlights

Ray V. Matthews, MD

Dr. Ray Matthews’ research interests include high risk percutaneous coronary intervention and the devices that provide hemodynamic support during these procedures. He is the Principal Investigator for the Shield II study, which is a multicenter randomized trial between the HeartMate PHP and the IMPELLA® 2.5 for hemodynamic support during the performance of high risk coronary intervention. Dr. Matthews has lectured nationally and internationally on this topic.

Catheter interventions for structural heart disease are also an interest of Dr. Matthews. He serves as Co-Principal Investigator for the PORTICO study. This is a randomized trial between commercially available transcatheter aortic valves and the PORTICO transcatheter valve in patients at high risk for surgical aortic valve replacement. Dr. Matthews is a physician educator and proctor for the performance of transcatheter aortic valve replacement (TAVR) and has lectured nationally and internationally on the topic. Dr. Matthews and USC have also been selected to be part of an early experimental trial of transcatheter mitral valve replacement scheduled to begin in 2017.

Leslie A. Saxon, MD

Dr. Saxon founded the USC Center for Body Computing (CBC) in 2006. The Center helps extend the reach and depth of CVTI research by working with outside entities as diverse as Apple, VSP Global, Qualcomm, Proteus Digital Health, St. Jude Medical, the United States Army Research Lab and the NFL. Collaborating with the CVTI and the Keck School of Medicine of USC, the CBC is conducting feasibility studies with state-of-the-art devices that can wirelessly monitor patients remotely, in addition to creating social networks, mobile apps and virtual care providers to help extend the reach of the CVTI cardiovascular specialists to our patient populations locally, and one day, nationally.

Faculty Research Areas

  • Congestive Heart Failure
    Cardiovascular Pharmacology
    Heart Disease in Pregnancy
    Valvular Heart Disease

  • Peripheral Artery Disease
    Cardiovascular Epidemiology
    Inflammatory Biomarkers

  • Percutaneous Cardiac Support Devices
    Coronary Artery Disease
    Advanced Cardiac Imaging

  • Atherosclerosis

  • Supported High Risk Coronary Intervention
    Non-Invasive Cardiac Pressures Determination by SmartPhone
    Percutaneous Therapy of Structural Heart Disease

  • Cardiac Imaging by Echocardiography
    Cardiovascular Disease in Women
    Right Ventricular Function

  • Digital Health and Virtual Care Models
    Augmented and Immersive Technology, Virtual Human Agents and Artificial Intelligence for Medicine
    Mobile Application Implementation and Research for Medical Applications
    Wearable and Implantable Sensor Technology and Big Data Analytics
    Elite Athletic & Military Performance & Resiliency Evaluation

  • Advanced Cardiac Imaging of Cardiovascular Substrates
    Heart Failure and Cardiac Devices

  • Echocardiography and Application in Clinical Settings

  • Preventative Cardiology
    Cardiovascular Disease in Women
    Cardiac Evaluation of Solid Organ Transplant Candidates
    Application of Information Technology in Medicine
    Signal processing for Improvement of Echocardiographic imaging

Contact Us

Cardiovascular Research Unit (CRU)

University of Southern California
Division of Cardiovascular Medicine
1510 San Pablo St, Suite 322
Los Angeles, CA 90033

Fax: 323-442-7610