Research Themes and Base
Research Themes and Special Interest Groups (SIGs)
Our Center serves as a focal point for faculty from throughout the University who join together with shared interests in Liver Diseases and other aspects of Digestive Diseases which are of common interest in Themes and subthemes, referred to as special interest groups (SIGs). The designation of SIG identifies groups of investigators who interact regularly, cross-collaborate extensively and share methods and resources. Many Center Members are listed in multiple Themes and have funding in separate Theme areas and their interests overlap the science in different Themes such as viral hepatitis/HCC, steatohepatitis, regenerative medicine. Theme coordinators are intimately involved in subthemes (SIGs) in their area.
The current Themes of the Center (since 2013) are the following:
- Viral Hepatitis and Hepatocellular Carcinoma (Coordinator, James Ou)
- Steatohepatitis and fibrosis (Coordinator, Hide Tsukamoto)
- Liver Injury: hepatotoxicity (inflammation, signal transduction, free radical/oxidative stress) and mitochondria (Coordinator, Neil Kaplowitz)
- Repair, Regenerative Medicine, and Developmental Biology (Coordinator, Laurie DeLeve)
Over time, the major change has been the growth in Center’s research activities in steatohepatitis and in liver injury, justifying dividing these into two themes. At the same time the interest in normal liver cell biology and transport has declined and signal transduction research has shifted from normal physiology to liver injury. The Regulatory Biology theme has sharpened its focus to regeneration, repair and development biology.