Precision Medicine

The USC–Tempus collaboration includes the Clinical Trial TIME Program, an AI-enabled platform designed to improve clinical trial identification, feasibility, and enrollment across USC-affiliated clinical sites.

The TIME Program uses structured and unstructured clinical data to help identify patients who may be eligible for clinical trials or targeted therapies—supporting more efficient trial matching while expanding patient access to investigational therapies.

Through the TIME Program, USC clinicians and investigators may:

• Identify potentially eligible patients for clinical trials more efficiently
• Support feasibility assessments for new and ongoing trials
• Improve trial enrollment and reduce missed opportunities for participation
• Strengthen the connection between clinical care and research activity

The TIME Program is integrated into clinical workflows and operates under established clinical, regulatory, and institutional governance frameworks. The platform is coordinated with the Norris Cancer Center Clinical Investigations Support Office and aligned with IRB, compliance, and patient privacy requirements.

Tempus Lens is a research analytics platform that enables investigators to explore large-scale, de-identified clinical and molecular datasets using advanced search, cohort-building, and visualization tools.

Through Lens, eligible USC faculty may:

• Conduct cohort discovery and feasibility analyses
• Explore patterns across clinical, molecular, and outcomes data
• Support hypothesis generation and study design
• Inform translational research questions and publications

Lens is a research-use platform and is not intended for clinical decision-making. Access is governed by USC policies and institutional approvals and is coordinated through MESH Strategic Partnerships. MESH Contact: David Birtwell

The Tempus Discover Program supports collaborative research projects that leverage Tempus data and analytical capabilities to advance scientific discovery and translational impact.

Through the Discover Program, USC faculty may:

• Propose research questions aligned with available data assets
• Collaborate on analyses that support publications and translational insights
• Accelerate early discovery through structured, project-based engagement

Participation in the Discover Program is optional, project-specific, and subject to institutional review and approval.

The USC–Tempus collaboration includes opportunities for AI co-development, enabling faculty to work collaboratively on the design, validation, and translation of AI-enabled tools that address unmet clinical and research needs.

Through structured, project-specific engagements with Tempus AI, Inc., eligible USC faculty may contribute domain expertise, clinical insight, and research innovation to the development of AI models, algorithms, diagnostics, or care-support tools intended for real-world application.

AI co-development activities may include:

• Defining clinically meaningful use cases and research questions
• Contributing scientific, clinical, or methodological expertise
• Participating in validation studies using approved data and workflows
• Advancing tools toward publication, clinical testing, or broader deployment

All AI co-development efforts are optional, proposal-driven, and governed by formal agreements that address data use, intellectual property, publication rights, and academic freedom. MESH Strategic Partnerships coordinates these engagements to ensure alignment with USC policies and institutional priorities.

The collaboration is between USC and Tempus AI, Inc. Participation under these agreements this agreement is limited to USC employees, consistent with university policies and governance.

The initial focus is oncology, reflecting the depth of molecular testing and clinical trial activity at the USC Norris Comprehensive Cancer Center, with the ability to extend to other disease areas.

No. Faculty research data is not automatically shared. All research use follows established USC governance, approvals, and formal agreements.

USC retains ownership of its data and intellectual property, consistent with university policy.

Tempus Lens and the Tempus Discover Program are research-focused resources. They are not clinical decision-support tools and do not replace existing clinical workflows. Faculty access is governed by USC policies and coordinated through MESH.

AI co-development refers to collaborative projects in which USC faculty and Tempus jointly contribute expertise to the development or validation of AI-enabled tools. Participation is optional and project-specific and is governed by formal agreements that define scope, data use, intellectual property, and publication rights.

Faculty are encouraged to contact MESH Strategic Partnerships to discuss eligibility and next steps.

The Clinical Trial TIME Program is an AI-enabled clinical trial matching platform used within clinical workflows to support trial identification and enrollment. It is primarily used by clinicians and clinical research teams and operates under existing clinical, regulatory, and institutional approvals. All Tempus TIME activities are coordinated through the Norris Cancer Center Clinical Investigations Support Office.